FI105031B - Menetelmä uusien terapeuttisesti käyttökelpoisten 1-fluorisyklopropyyli-6-fluori-1,4-dihydro-4-oksokinoliini-3-karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 1-fluorisyklopropyyli-6-fluori-1,4-dihydro-4-oksokinoliini-3-karboksyylihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI105031B
FI105031B FI935830A FI935830A FI105031B FI 105031 B FI105031 B FI 105031B FI 935830 A FI935830 A FI 935830A FI 935830 A FI935830 A FI 935830A FI 105031 B FI105031 B FI 105031B
Authority
FI
Finland
Prior art keywords
carboxylic acid
fluorocyclopropyl
dihydro
oxoquinoline
diazabicyclo
Prior art date
Application number
FI935830A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI935830A0 (fi
FI935830A (fi
Inventor
Youichi Kimura
Makoto Takemura
Norikazu Matsuhashi
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of FI935830A0 publication Critical patent/FI935830A0/fi
Publication of FI935830A publication Critical patent/FI935830A/fi
Application granted granted Critical
Publication of FI105031B publication Critical patent/FI105031B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI935830A 1992-12-25 1993-12-23 Menetelmä uusien terapeuttisesti käyttökelpoisten 1-fluorisyklopropyyli-6-fluori-1,4-dihydro-4-oksokinoliini-3-karboksyylihappojohdannaisten valmistamiseksi FI105031B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34603092 1992-12-25
JP34603092 1992-12-25

Publications (3)

Publication Number Publication Date
FI935830A0 FI935830A0 (fi) 1993-12-23
FI935830A FI935830A (fi) 1994-06-26
FI105031B true FI105031B (fi) 2000-05-31

Family

ID=18380663

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935830A FI105031B (fi) 1992-12-25 1993-12-23 Menetelmä uusien terapeuttisesti käyttökelpoisten 1-fluorisyklopropyyli-6-fluori-1,4-dihydro-4-oksokinoliini-3-karboksyylihappojohdannaisten valmistamiseksi

Country Status (17)

Country Link
US (1) US5654318A (de)
EP (1) EP0603887B1 (de)
JP (1) JP3268098B2 (de)
KR (1) KR100295483B1 (de)
CN (1) CN1037441C (de)
AT (1) ATE251157T1 (de)
AU (1) AU669948B2 (de)
CA (1) CA2112165C (de)
DE (1) DE69333223T2 (de)
DK (1) DK0603887T3 (de)
ES (1) ES2208636T3 (de)
FI (1) FI105031B (de)
NO (1) NO301165B1 (de)
PH (1) PH31587A (de)
PT (1) PT603887E (de)
RU (1) RU2125046C1 (de)
TW (1) TW264476B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148277B1 (ko) * 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
KR960004339A (ko) * 1994-07-02 1996-02-23 임성기 신규한 퀴놀린계 화합물 및 그 의 제조방법
WO1996011194A1 (fr) * 1994-10-06 1996-04-18 Dainippon Pharmaceutical Co., Ltd. Derive d'acide pyridonecarboxylique et intermediaire servant a effectuer sa synthese
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
JP4338217B2 (ja) * 1996-02-23 2009-10-07 バイエル・アニマル・ヘルス・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 置換可能な８―シアノ―１―シクロプロピル―７―（２，８―ジアザビシクロ―［４．３．０］―ノナン―８―イル）―６―フルオロ―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸およびそれらの誘導体
AU704735B2 (en) * 1996-02-27 1999-04-29 Dainippon Pharmaceutical Co. Ltd. Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereo
DK0947513T3 (da) * 1996-10-25 2004-08-30 Daiichi Seiyaku Co Tricykliske aminderivater
DE19652239A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
DE19931115A1 (de) * 1999-07-06 2001-01-11 Bayer Ag Racemisierung von R, S-Dioxo-Benzylpyrrolopiperidin
DK1262477T3 (da) * 2000-02-09 2008-12-01 Daiichi Sankyo Co Ltd Antibakterielle midler, der er virksomme mod syrefaste bakterier og indeholder pyridoncarboxylsyrer som aktiv ingrediens
MY137020A (en) 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
DE10022369A1 (de) 2000-05-08 2001-11-15 Bayer Ag Verfahren zur Herstellung von Piperidinen
EP1888066B1 (de) * 2005-05-25 2012-01-11 Merck Sharp & Dohme Corp. Aminocyclohexane als dipeptidylpeptidase-iv-hemmer zur behandlung bzw. prävention von diabetes
CN102101861B (zh) * 2008-07-01 2012-07-18 韶远化学科技（上海）有限公司 含氮双杂环医药中间体的合成及工艺方法
EP2429991B1 (de) 2009-05-15 2014-09-10 Redx Pharma Limited Redox-wirkstoffderivate
CN102675308A (zh) * 2011-03-17 2012-09-19 苏州中科天马肽工程中心有限公司 一种制备8-苄基-2,8-二氮杂二环[4.3.0]壬烷的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210805A (en) * 1984-01-19 1988-04-29 Norton Co Aluminous abrasive grits or shaped bodies
EP0191185B1 (de) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Chinolincarbonsäure-Derivate
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
CA2030217A1 (en) * 1989-11-21 1991-05-22 Jun Imose Pyridone-carboxylic acid derivatives useful as veterinary medicines
JPH03188080A (ja) * 1989-12-15 1991-08-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
ES2151488T3 (es) * 1991-05-28 2001-01-01 Daiichi Seiyaku Co Derivado de acido piridonacarboxilico.
TW209865B (de) * 1992-01-10 1993-07-21 Bayer Ag
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate

Also Published As

Publication number Publication date
AU669948B2 (en) 1996-06-27
FI935830A0 (fi) 1993-12-23
JP3268098B2 (ja) 2002-03-25
NO301165B1 (no) 1997-09-22
ATE251157T1 (de) 2003-10-15
JPH06239857A (ja) 1994-08-30
EP0603887A2 (de) 1994-06-29
CA2112165A1 (en) 1994-06-26
EP0603887A3 (de) 1995-04-26
TW264476B (de) 1995-12-01
KR940014397A (ko) 1994-07-18
CN1037441C (zh) 1998-02-18
PT603887E (pt) 2004-02-27
FI935830A (fi) 1994-06-26
CA2112165C (en) 2003-04-08
AU5269593A (en) 1994-07-07
NO934753L (no) 1994-06-27
RU2125046C1 (ru) 1999-01-20
PH31587A (en) 1998-11-03
KR100295483B1 (ko) 2001-09-17
DE69333223D1 (de) 2003-11-06
EP0603887B1 (de) 2003-10-01
DK0603887T3 (da) 2004-01-26
NO934753D0 (no) 1993-12-22
DE69333223T2 (de) 2004-08-05
ES2208636T3 (es) 2004-06-16
US5654318A (en) 1997-08-05
CN1095068A (zh) 1994-11-16

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