FI103971B - Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi Download PDF

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Publication number
FI103971B
FI103971B FI924397A FI924397A FI103971B FI 103971 B FI103971 B FI 103971B FI 924397 A FI924397 A FI 924397A FI 924397 A FI924397 A FI 924397A FI 103971 B FI103971 B FI 103971B
Authority
FI
Finland
Prior art keywords
formula
methyl
compound
pyrido
mixture
Prior art date
Application number
FI924397A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI103971B1 (fi
FI924397L (fi
FI924397A0 (fi
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of FI924397A0 publication Critical patent/FI924397A0/fi
Publication of FI924397L publication Critical patent/FI924397L/fi
Application granted granted Critical
Publication of FI103971B1 publication Critical patent/FI103971B1/fi
Publication of FI103971B publication Critical patent/FI103971B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924397A 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi FI103971B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78202591 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
GB9207560 1992-04-07
US90148592 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (4)

Publication Number Publication Date
FI924397A0 FI924397A0 (fi) 1992-09-30
FI924397L FI924397L (fi) 1993-04-25
FI103971B1 FI103971B1 (fi) 1999-10-29
FI103971B true FI103971B (fi) 1999-10-29

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924397A FI103971B (fi) 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0539086B1 (https=)
JP (1) JP3240192B2 (https=)
KR (1) KR100286624B1 (https=)
CN (2) CN1039324C (https=)
AT (1) ATE161537T1 (https=)
AU (1) AU653635B2 (https=)
CA (1) CA2080705C (https=)
DE (1) DE69223734T2 (https=)
DK (1) DK0539086T3 (https=)
ES (1) ES2111617T3 (https=)
FI (1) FI103971B (https=)
GR (1) GR3025926T3 (https=)
HK (1) HK1003031A1 (https=)
HU (2) HU218786B (https=)
IL (1) IL103436A (https=)
LV (1) LV12047B (https=)
NO (1) NO301275B1 (https=)
SG (1) SG47626A1 (https=)
SK (1) SK322192A3 (https=)
TW (1) TW226375B (https=)
UA (1) UA27748C2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
SG47714A1 (en) * 1993-03-24 1998-04-17 American Home Prod Substituted pyridopyrimidines as antihypertensives
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
NZ549535A (en) 2004-03-17 2010-11-26 Novartis Ag Use of aliskiren for treating renal and other disorders
AU2005294318A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2527360B1 (en) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
PT2160190E (pt) * 2007-06-07 2016-01-27 Sigma Tau Ind Farmaceuti Derivados de 5beta, 14 beta-androstano úteis para o tratamento de doenças causadas por fibroses de órgão
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
AP2014007766A0 (en) 2011-12-15 2014-07-31 Takeda Pharmaceuticals Usa Inc Combination os azilsartan and chlorthlidone for treating hypertension black patients
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
CA2075627A1 (en) * 1990-02-13 1991-08-14 William J. Greenlee Angiotensin ii antagonists incorporating a substituted benzyl element
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
EP0539086A2 (en) 1993-04-28
CN1072682A (zh) 1993-06-02
TW226375B (https=) 1994-07-11
UA27748C2 (uk) 2000-10-16
HU218786B (hu) 2000-12-28
DE69223734D1 (de) 1998-02-05
CA2080705C (en) 2002-12-03
HU211915A9 (en) 1996-01-29
ATE161537T1 (de) 1998-01-15
HUT62893A (en) 1993-06-28
JP3240192B2 (ja) 2001-12-17
IL103436A (en) 1996-03-31
SK280292B6 (sk) 1999-11-08
NO924121D0 (no) 1992-10-23
JPH05222039A (ja) 1993-08-31
HK1003031A1 (en) 1998-09-30
CA2080705A1 (en) 1993-04-25
FI103971B1 (fi) 1999-10-29
EP0539086B1 (en) 1997-12-29
SG47626A1 (en) 1998-04-17
DE69223734T2 (de) 1998-04-16
AU2607992A (en) 1993-04-29
EP0539086A3 (en) 1993-06-16
KR930007949A (ko) 1993-05-20
GR3025926T3 (en) 1998-04-30
CN1175414A (zh) 1998-03-11
NO301275B1 (no) 1997-10-06
KR100286624B1 (ko) 2001-05-02
LV12047B (en) 1998-08-20
SK322192A3 (en) 1999-11-08
FI924397L (fi) 1993-04-25
NO924121L (no) 1993-04-26
HU9203161D0 (en) 1992-12-28
CN1039324C (zh) 1998-07-29
AU653635B2 (en) 1994-10-06
LV12047A (lv) 1998-05-20
IL103436A0 (en) 1993-03-15
DK0539086T3 (da) 1998-02-02
FI924397A0 (fi) 1992-09-30
ES2111617T3 (es) 1998-03-16

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MA Patent expired