FI103971B - Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI103971B
FI103971B FI924397A FI924397A FI103971B FI 103971 B FI103971 B FI 103971B FI 924397 A FI924397 A FI 924397A FI 924397 A FI924397 A FI 924397A FI 103971 B FI103971 B FI 103971B
Authority
FI
Finland
Prior art keywords
formula
methyl
compound
pyrido
mixture
Prior art date
Application number
FI924397A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924397L (fi
FI103971B1 (fi
FI924397A0 (fi
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of FI924397A0 publication Critical patent/FI924397A0/fi
Publication of FI924397L publication Critical patent/FI924397L/fi
Application granted granted Critical
Publication of FI103971B1 publication Critical patent/FI103971B1/fi
Publication of FI103971B publication Critical patent/FI103971B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924397A 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi FI103971B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78202591 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560 1992-04-07
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US90148592 1992-06-25

Publications (4)

Publication Number Publication Date
FI924397A0 FI924397A0 (fi) 1992-09-30
FI924397L FI924397L (fi) 1993-04-25
FI103971B1 FI103971B1 (fi) 1999-10-29
FI103971B true FI103971B (fi) 1999-10-29

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924397A FI103971B (fi) 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0539086B1 (enEXAMPLES)
JP (1) JP3240192B2 (enEXAMPLES)
KR (1) KR100286624B1 (enEXAMPLES)
CN (2) CN1039324C (enEXAMPLES)
AT (1) ATE161537T1 (enEXAMPLES)
AU (1) AU653635B2 (enEXAMPLES)
CA (1) CA2080705C (enEXAMPLES)
DE (1) DE69223734T2 (enEXAMPLES)
DK (1) DK0539086T3 (enEXAMPLES)
ES (1) ES2111617T3 (enEXAMPLES)
FI (1) FI103971B (enEXAMPLES)
GR (1) GR3025926T3 (enEXAMPLES)
HK (1) HK1003031A1 (enEXAMPLES)
HU (2) HU218786B (enEXAMPLES)
IL (1) IL103436A (enEXAMPLES)
LV (1) LV12047B (enEXAMPLES)
NO (1) NO301275B1 (enEXAMPLES)
SG (1) SG47626A1 (enEXAMPLES)
SK (1) SK280292B6 (enEXAMPLES)
TW (1) TW226375B (enEXAMPLES)
UA (1) UA27748C2 (enEXAMPLES)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK280887B6 (sk) * 1991-11-18 2000-09-12 E. I. Du Pont De Nemours And Company Spôsob výroby tetrazolylbifenylových zlúčenín a medziprodukty tohto spôsobu
ATE175413T1 (de) * 1993-03-24 1999-01-15 American Home Prod Substituierte pyridopyrimidine als antihypertensiva
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
WO2005089731A2 (en) 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
PT1799199E (pt) 2004-10-08 2012-07-03 Novartis Ag Uso de inibidores da renina para a prevenção ou tratamento da disfunção diastólica ou insuficiência cardíaca diastólica
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
KR101530019B1 (ko) * 2007-06-07 2015-06-18 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 혈관성형술 또는 동맥내막절제술 후 재협착 및 장기 섬유증으로 인한 질환의 치료에 유용한 5베타, 14베타-안드로스테인 유도체
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP6050264B2 (ja) 2011-03-16 2016-12-21 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
BR112014014527A2 (pt) 2011-12-15 2017-06-13 Takeda Pharmaceuticals Usa Inc combinações de azilsartan e clorotalidona para tratar hipertensão em pacientes negros
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
EP0517812A4 (en) * 1990-02-13 1995-10-18 Merck & Co Inc Angiotensin ii antagonists incorporating a substituted benzyl element
IL100917A0 (en) 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
DE69223734T2 (de) 1998-04-16
LV12047A (lv) 1998-05-20
AU2607992A (en) 1993-04-29
GR3025926T3 (en) 1998-04-30
CA2080705C (en) 2002-12-03
NO924121D0 (no) 1992-10-23
HUT62893A (en) 1993-06-28
DE69223734D1 (de) 1998-02-05
NO924121L (no) 1993-04-26
HU9203161D0 (en) 1992-12-28
FI924397L (fi) 1993-04-25
UA27748C2 (uk) 2000-10-16
CN1039324C (zh) 1998-07-29
JP3240192B2 (ja) 2001-12-17
AU653635B2 (en) 1994-10-06
KR100286624B1 (ko) 2001-05-02
HU211915A9 (en) 1996-01-29
FI103971B1 (fi) 1999-10-29
SK322192A3 (en) 1999-11-08
FI924397A0 (fi) 1992-09-30
KR930007949A (ko) 1993-05-20
HK1003031A1 (en) 1998-09-30
CN1072682A (zh) 1993-06-02
ES2111617T3 (es) 1998-03-16
HU218786B (hu) 2000-12-28
DK0539086T3 (da) 1998-02-02
CA2080705A1 (en) 1993-04-25
ATE161537T1 (de) 1998-01-15
EP0539086A2 (en) 1993-04-28
LV12047B (en) 1998-08-20
SK280292B6 (sk) 1999-11-08
NO301275B1 (no) 1997-10-06
TW226375B (enEXAMPLES) 1994-07-11
IL103436A0 (en) 1993-03-15
CN1175414A (zh) 1998-03-11
EP0539086A3 (en) 1993-06-16
JPH05222039A (ja) 1993-08-31
SG47626A1 (en) 1998-04-17
EP0539086B1 (en) 1997-12-29
IL103436A (en) 1996-03-31

Similar Documents

Publication Publication Date Title
FI103971B (fi) Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido£2,3-d|pyrimidinonijohdannaisten valmistamiseksi
RU2113437C1 (ru) Замещенные пиримидины, или их фармацевтически приемлемые соли, или n-оксиды, способы их получения и фармацевтическая композиция на их основе
AU2019283921B2 (en) Indole carboxamide compounds useful as kinase inhibitors
ES2675583T3 (es) Bencimidazoles moduladores de TNF-alfa
DE69030206T2 (de) Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung
DE69233113T2 (de) Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung
HK1003031B (en) Condensed pyrimidine derivatives and their use as angiotensine ii antagonists
DE69208263T2 (de) Substituierte aminopyrimidine als angiotensin ii antagonisten
JP6549311B2 (ja) インドール誘導体、その調製方法および医薬におけるその使用
EP2763533B1 (en) Triazolyl pde10 inhibitors
JP2021528401A (ja) Ｍａｌｔ１阻害剤としてのピラゾール誘導体
CA2851082A1 (en) 1,3-substituted azetidine pde10 inhibitors
CS36192A3 (en) Nitrogen hetero cycles, process of their preparation and pharmaceuticalcompositions containing said hetero cycles
SK73293A3 (en) Benzimidazoles, process for their preparation and medicaments contained this compounds
SK81299A3 (en) Imidazopyridazine compounds, pharmaceutical composition containing the same and their use
WO2012011549A1 (ja) Ｐ２ｘ４受容体拮抗剤
WO2024156938A1 (en) Cbl-b inhibitors
WO1994011365A1 (en) Substituted benzimidazoles and quinazolines as antihypertensives
US5256654A (en) Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
WO2000050416A1 (fr) Derives d'acide heteroquinolinecarboxylique 6-substitues et sels d'addition associes, et procedes de preparation de ces derives et de leurs sels
GB2265899A (en) Substituted pyrimidines
HU222240B1 (hu) Szubsztituált pirido-pirimidin-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
AU2002314064A1 (en) Novel pyridylmethylaminopyrimidines

Legal Events

Date Code Title Description
MA Patent expired