FI102907B1 - Mutatoitu subtilisiini-proteaasi - Google Patents

Mutatoitu subtilisiini-proteaasi

Info

Publication number
FI102907B1
FI102907B1 FI916050A FI916050A FI102907B1 FI 102907 B1 FI102907 B1 FI 102907B1 FI 916050 A FI916050 A FI 916050A FI 916050 A FI916050 A FI 916050A FI 102907 B1 FI102907 B1 FI 102907B1
Authority
FI
Finland
Prior art keywords
enzymes
subtilisin protease
mutated subtilisin
genes
mutated
Prior art date
Application number
FI916050A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI916050A0 (fi
FI102907B (fi
Inventor
Sven Branner
Sven Hastrup
Ole Hvilsted Olsen
Leif Noerskov-Lauritsen
Merete Simonsen
Dorrit Aaslyng
Eric Casteleijn
Maarten Robert Egmond
Johan Haverkamp
John David Marugg
Arnoldus Theodorus Anth Mooren
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8119873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI102907(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI916050A0 publication Critical patent/FI916050A0/fi
Application granted granted Critical
Publication of FI102907B publication Critical patent/FI102907B/fi
Publication of FI102907B1 publication Critical patent/FI102907B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
FI916050A 1989-06-26 1991-12-20 Mutatoitu subtilisiini-proteaasi FI102907B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK316989A DK316989D0 (da) 1989-06-26 1989-06-26 Enzymer
DK316989 1989-06-26
PCT/DK1990/000164 WO1991000345A1 (en) 1989-06-26 1990-06-26 A mutated subtilisin protease
DK9000164 1990-06-26

Publications (3)

Publication Number Publication Date
FI916050A0 FI916050A0 (fi) 1991-12-20
FI102907B FI102907B (fi) 1999-03-15
FI102907B1 true FI102907B1 (fi) 1999-03-15

Family

ID=8119873

Family Applications (3)

Application Number Title Priority Date Filing Date
FI916050A FI102907B1 (fi) 1989-06-26 1991-12-20 Mutatoitu subtilisiini-proteaasi
FI990023A FI112500B (fi) 1989-06-26 1999-01-08 Mutatoitu subtilisiiniproteaasi
FI20031209A FI20031209A (fi) 1989-06-26 2003-08-28 Mutatoitu subtilisiiniproteaasi

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI990023A FI112500B (fi) 1989-06-26 1999-01-08 Mutatoitu subtilisiiniproteaasi
FI20031209A FI20031209A (fi) 1989-06-26 2003-08-28 Mutatoitu subtilisiiniproteaasi

Country Status (12)

Country Link
EP (5) EP1555314B1 (de)
JP (3) JP3343115B2 (de)
KR (1) KR100258459B1 (de)
AT (5) ATE362525T1 (de)
AU (1) AU5956690A (de)
BR (1) BR9007477A (de)
CA (1) CA2062732C (de)
DE (6) DE69034241T2 (de)
DK (3) DK316989D0 (de)
ES (2) ES2152209T3 (de)
FI (3) FI102907B1 (de)
WO (1) WO1991000345A1 (de)

Families Citing this family (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287841B1 (en) 1988-02-11 2001-09-11 Genencor International, Inc. High alkaline serine protease
US5352603A (en) * 1989-08-31 1994-10-04 Kali-Chemie Ag Highly alkaline proteases
DE4023458A1 (de) * 1989-08-31 1991-03-07 Kali Chemie Ag Neue hochalkalische proteasen
US6271012B1 (en) * 1989-10-11 2001-08-07 Genencor International, Inc. Protease muteins and their use in detergents
DK271490D0 (da) * 1990-11-14 1990-11-14 Novo Nordisk As Detergentkomposition
DE69130113T2 (de) * 1990-12-05 1999-05-12 Novo Nordisk A/S, Bagsvaerd Proteine mit geänderten epitopen und verfahren zur deren herstellung
ES2110488T3 (es) * 1990-12-21 1998-02-16 Novo Nordisk As Mutantes enzimaticos con un bajo grado de variacion de la carga molecular en un intervalo de ph.
US5482849A (en) * 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
DE4106525A1 (de) * 1991-03-01 1992-09-10 Solvay Enzymes Gmbh & Co Kg Verfahren zur verbesserung der stabilitaet von hochalkalischen proteasen
EP0583339B1 (de) * 1991-05-01 1998-07-08 Novo Nordisk A/S Stabilisierte enzyme und waschmittelzusammensetzungen
ES2090481T3 (es) * 1991-05-01 1996-10-16 Unilever Nv Composiciones detergentes que contienen enzimas estabilizadas.
US5275945A (en) * 1991-10-08 1994-01-04 Vista Chemical Company Alkaline proteases stable in heavy-duty detergent liquids
HUT66846A (en) * 1991-10-16 1995-01-30 Unilever Nv Aqueous enzymatic detergent compositions
PL178045B1 (pl) * 1992-07-17 2000-02-29 Genencor Int Mutant proteazy do stosowania w detergentach, sekwencja DNA kodująca mutanta proteazy, sposób otrzymywania mutanta proteazy oraz kompozycja detergentowa
EP0663950B1 (de) * 1992-10-06 2004-03-17 Novozymes A/S Zellulosevarianten
DE4304161A1 (de) * 1993-02-12 1994-08-25 Solvay Enzymes Gmbh & Co Kg Verbesserte hochalkalische Proteasen
DK39093D0 (da) * 1993-04-01 1993-04-01 Novo Nordisk As Enzym
US6440717B1 (en) 1993-09-15 2002-08-27 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis
US6436690B1 (en) 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US5866526A (en) * 1993-10-04 1999-02-02 Novo Nordisk A/S Enzyme preparation comprising a modified enzyme
MA23346A1 (fr) 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
DE69432954T2 (de) * 1993-10-14 2004-04-22 The Procter & Gamble Company, Cincinnati Proteasen enthaltende bleichmittelzusammensetzungen
AU8079794A (en) * 1993-10-14 1995-05-04 Procter & Gamble Company, The Protease-containing cleaning compositions
EP1921148B1 (de) 1994-02-24 2011-06-08 Henkel AG & Co. KGaA Verbesserte Enzyme und Detergentien damit
ES2364774T3 (es) * 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
US6110884A (en) * 1994-03-29 2000-08-29 Novo Nordisk A/S Protease variants
US6599730B1 (en) 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
US6066611A (en) * 1994-10-13 2000-05-23 The Procter & Gamble Company Bleaching compositions comprising protease enzymes
US6455295B1 (en) 1995-03-08 2002-09-24 The Procter & Gamble Company Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
IL117352A0 (en) * 1995-03-09 1996-07-23 Procter & Gamble Thermitase variants having decreased adsorption and increased hydrolysis
US6475765B1 (en) 1995-03-09 2002-11-05 Procter & Gamble Company Subtilisin DY variants having decreased adsorption and increased hydrolysis
IL117350A0 (en) 1995-03-09 1996-07-23 Procter & Gamble Proteinase k variants having decreased adsorption and increased hydrolysis
EP0824585B1 (de) * 1995-05-05 2009-04-22 Novozymes A/S Protease-varianten und verbindungen
US6682924B1 (en) 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
US5837517A (en) 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
CA2270180C (en) * 1996-11-04 2011-01-11 Novo Nordisk A/S Subtilase variants and compositions
CN1554750B (zh) * 1996-11-04 2011-05-18 诺维信公司 枯草酶变种及组合物
EP1012251A1 (de) 1997-08-29 2000-06-28 Novo Nordisk A/S Varianten der protease und zusammensetzungen
AU8798198A (en) 1997-08-29 1999-03-22 Novo Nordisk A/S Protease variants and compositions
ES2368718T3 (es) 1997-10-23 2011-11-21 Danisco Us Inc. Variantes de subtilisina con múltiples sustituciones.
MA25044A1 (fr) 1997-10-23 2000-10-01 Procter & Gamble Compositions de lavage contenant des variants de proteases multisubstituees.
EP1032655B1 (de) 1997-11-21 2005-06-29 Novozymes A/S Protease-varianten und zusammensetzungen
US6780629B2 (en) 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
US6773907B2 (en) 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
JP2002500019A (ja) † 1997-12-24 2002-01-08 ジェネンコア インターナショナル インコーポレーテッド 好ましい酵素および／または好ましい洗剤組成物についての改良された分析方法
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
WO2000024924A2 (en) * 1998-10-23 2000-05-04 The Procter & Gamble Company Methods for screening protease variants for use in detergent compositions
JP4647788B2 (ja) * 1998-12-18 2011-03-09 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
EP1803817B1 (de) 1998-12-18 2011-04-06 Novozymes A/S Subtilase Enzyme der I-S1- und I-S2-Untergruppen mit einem zusätzlichen Aminosäurerest in einer aktiven Schleifenregion
BRPI9916352B1 (pt) * 1998-12-18 2016-04-19 Novozymes As enzima de subtilase isolada dos subgrupos i-s1 e i-s2, subtilase, seqüência isolada de dna, vetor de expressão, célula hospedeira microbiana, método para produzir uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou de uma variante de subtilase ou de uma composição de enzima
ATE408676T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 132 und 133
EP1183340B1 (de) 1999-05-20 2008-09-03 Novozymes A/S Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurerest zwischen positionen 126 und 127
AU4393100A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 125 and 126
AU4392900A (en) 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 127 and 128
EP1183338B2 (de) † 1999-05-20 2012-06-13 Novozymes A/S Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 97 und 98
ATE408680T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129
WO2000071687A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 129 and 130
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
US6727085B2 (en) 1999-12-15 2004-04-27 Fanoe Tina Sejersgaard Subtilase variants having an improved wash performance on egg stains
US6777218B1 (en) 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
EP1313846B1 (de) 2000-08-21 2013-10-16 Novozymes A/S Subtilase enzyme
FI111728B (fi) * 2000-10-13 2003-09-15 Valtion Teknillinen Menetelmä proteiinin rakenteen muuttamiseksi
WO2002031133A1 (en) 2000-10-13 2002-04-18 Novozymes A/S Subtilase variants
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US6803222B2 (en) * 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
GB0102929D0 (en) * 2001-02-06 2001-03-21 Inpharmatica Ltd Novel proteins
US20050101012A1 (en) 2001-03-12 2005-05-12 Gerold Schuler CD4+CD25+ regulatory T cells from human blood
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
EP1321513A1 (de) * 2001-12-21 2003-06-25 Direvo Biotech AG Subtilisin variante mit verbesserten Eigenschaften
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
JP4703113B2 (ja) * 2002-01-16 2011-06-15 ジェネンコー・インターナショナル・インク 複数置換プロテアーゼ変異体
EP1490485B1 (de) 2002-03-27 2015-03-04 Novozymes A/S Granulate mit filamentösen schichten
US8222033B2 (en) 2002-08-12 2012-07-17 Argos Therapeutics, Inc. CD4+CD25− T cells and Tr1-like regulatory T cells
US7888093B2 (en) 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
TWI319007B (en) 2002-11-06 2010-01-01 Novozymes As Subtilase variants
ATE461276T1 (de) 2003-01-27 2010-04-15 Novozymes As Enzymstabilisierung
WO2004072221A2 (en) 2003-02-07 2004-08-26 Novozymes A/S Proteases
US20040254087A1 (en) 2003-03-18 2004-12-16 Novozymes A/S Coated enzyme granules
ATE407202T1 (de) 2003-05-07 2008-09-15 Novozymes As Enzymvarianten von subtilisin (subtilasen)
CA2539693A1 (en) 2003-10-10 2005-04-21 Novozymes A/S Protease variants
EP1678296B1 (de) 2003-10-23 2011-07-13 Novozymes A/S Protease mit verbesserter stabilität in detergentien
CA2547651C (en) 2003-12-01 2015-06-23 Cambridge University Technical Services Limited Anti-inflammatory agents
EP2325318A1 (de) 2004-02-13 2011-05-25 Novozymes A/S Proteasevarianten
CN101014704A (zh) 2004-06-21 2007-08-08 诺维信公司 蛋白酶
WO2006031554A2 (en) 2004-09-10 2006-03-23 Novozymes North America, Inc. Methods for preventing, removing, reducing, or disrupting biofilm
EP2143339B1 (de) 2004-09-27 2018-10-24 Novozymes A/S Enzymkörner
EP2385112B1 (de) 2005-07-08 2016-11-30 Novozymes A/S Subtilasevarianten
WO2007036235A1 (en) 2005-09-30 2007-04-05 Novozymes A/S Immobilization of enzymes
EP1994130A1 (de) 2006-03-02 2008-11-26 Novozymes A/S Leistungsstarkes verkapselungsverfahren
WO2007113241A1 (en) 2006-03-31 2007-10-11 Novozymes A/S A stabilized liquid enzyme composition
BRPI0709978A2 (pt) 2006-04-14 2011-08-02 Genencor Int tratamento em etapa única de produtos têxteis
EP2013339B1 (de) 2006-04-20 2013-09-11 Novozymes A/S Savinase-varianten mit verbesserter waschleistung gegen eiflecken
CN101490548A (zh) * 2006-06-02 2009-07-22 哈佛大学校长及研究员协会 蛋白质表面重建
CA2656298A1 (en) 2006-06-02 2007-12-13 President And Fellows Of Harvard College Protein surface remodeling
KR20090031906A (ko) * 2006-07-18 2009-03-30 다니스코 유에스 인크. 광범위한 온도에 걸쳐 활성인 프로테아제 변이형
EP2051591B1 (de) 2006-08-07 2016-04-20 Novozymes A/S Enzymgranulat für tierfutter
EP2051590B1 (de) 2006-08-07 2016-04-20 Novozymes A/S Enzymgranulat für tierfutter
CN101522878B (zh) 2006-10-06 2012-11-14 诺维信公司 洗涤剂组合物及其中酶组合的使用
JP2008212084A (ja) 2007-03-06 2008-09-18 Kao Corp アルカリプロテアーゼ
US20100190682A1 (en) 2007-04-30 2010-07-29 Sang-Kyu Lee Use of protein hydrolysates to stabilize metalloprotease detergent formulations
RU2569106C2 (ru) * 2007-06-06 2015-11-20 ДАНИСКО ЮЭс, ИНК., ДЖЕНЕНКОР ДИВИЖН Способы улучшения эффективности белков
BRPI0812206A2 (pt) * 2007-06-06 2014-10-14 Danisco Us Inc Genencor Div Métodos para melhorar o desempenho de proteínas
SG148934A1 (en) 2007-06-11 2009-01-29 Novozymes As A process for combined biopolishing and bleach clean-up
EP2262885B1 (de) 2008-03-28 2013-05-15 Novozymes A/S Partikel mit einem enzymausgelösten freisetzungssystem
BRPI0915728A2 (pt) 2008-07-07 2015-10-27 Basf Se composição enzimática, processo para preparar a composição, uso da composição enzimática, e, composição detergente.
WO2010028941A1 (en) 2008-09-12 2010-03-18 Unilever Plc Dispenser and pretreater for viscous liquids
EP2647692A3 (de) * 2008-11-11 2014-01-22 The Procter and Gamble Company Zusammensetzungen und Verfahren mit Serinproteasevarianten
AR074311A1 (es) 2008-11-11 2011-01-05 Danisco Us Inc Variantes de subtilisina aislada de bacillus, con actividad proteolitica
EP2202290A1 (de) 2008-12-23 2010-06-30 Unilever PLC Fließfähige Waschmittelzusammensetzung und Verpackung dafür
WO2010129023A2 (en) 2009-04-28 2010-11-11 President And Fellows Of Harvard College Supercharged proteins for cell penetration
FI121711B (fi) 2009-04-30 2011-03-15 Ab Enzymes Oy Sieniperäinen seriiniproteaasi ja sen käyttö
FI121712B (fi) 2009-04-30 2011-03-15 Ab Enzymes Oy Uusi sieniperäinen proteaasi ja sen käyttö
FI121851B (fi) 2009-07-08 2011-05-13 Ab Enzymes Oy Sieniperäinen proteaasi ja sen käyttö
BR112012028467B1 (pt) * 2010-05-06 2021-02-17 Danisco Us Inc. variantes de subtilisina, seu método de produção, ácido nucleico, e método de limpeza
DE102010028951A1 (de) 2010-05-12 2011-11-17 Henkel Ag & Co. Kgaa Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Lipase
US9222078B2 (en) 2010-07-01 2015-12-29 Novozymes A/S Bleaching of pulp
WO2012022777A1 (en) 2010-08-19 2012-02-23 Novozymes A/S Induced sporulation screening method
FI123942B (fi) 2010-10-29 2013-12-31 Ab Enzymes Oy Sieniperäisen seriiniproteaasin variantteja
DE102011005354A1 (de) 2011-03-10 2012-09-13 Henkel Ag & Co. Kgaa Leistungsverbesserte Proteasevarianten
FI123425B (fi) 2011-03-31 2013-04-30 Ab Enzymes Oy Proteaasientsyymi ja sen käytöt
GB201106409D0 (en) 2011-04-15 2011-06-01 Revolymer Ltd Novel composite
GB201106408D0 (en) 2011-04-15 2011-06-01 Revolymer Ltd Novel composite
GB201106391D0 (en) 2011-04-15 2011-06-01 Reckitt & Colman Overseas Novel composite
DK2702153T3 (en) 2011-04-28 2019-03-18 Novozymes Inc Polypeptides with endoglucanase activity and polynucleotides encoding them
CN106065381B (zh) * 2011-05-05 2019-07-26 宝洁公司 包含丝氨酸蛋白酶变体的组合物和方法
BR112013027963A2 (pt) * 2011-05-05 2016-11-29 Danisco Us Inc "variante de subtilisina com atividade proteolítica, ácido nucleico, vetor de expressão, célula hospedeira, composição e método de limpeza".
WO2013024143A1 (en) 2011-08-18 2013-02-21 Unilever Plc Enzyme system
CA2847879C (en) 2011-09-09 2020-06-23 Novozymes A/S Improving properties of paper materials
EP2847313A1 (de) 2012-05-10 2015-03-18 Unilever PLC Pflegeenzymsystem
WO2014067933A1 (en) 2012-10-31 2014-05-08 C-Lecta Gmbh Bioactive carrier preparation for enhanced safety in care products and food
EP2740840A1 (de) 2012-12-07 2014-06-11 Novozymes A/S Verbesserter Ablass von Papiermasse
WO2016001449A1 (en) 2014-07-04 2016-01-07 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP3739029A1 (de) 2014-07-04 2020-11-18 Novozymes A/S Subtilasevarianten und polynukleotide zur codierung davon
WO2016007309A1 (en) 2014-07-07 2016-01-14 Novozymes A/S Use of prehydrolysate liquor in engineered wood
US10683491B2 (en) 2014-12-04 2020-06-16 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2016096714A1 (en) * 2014-12-15 2016-06-23 Henkel Ag & Co. Kgaa Detergent composition comprising subtilase variants
CN107002059A (zh) 2014-12-19 2017-08-01 诺维信公司 蛋白酶变体以及对其进行编码的多核苷酸
CN107109388A (zh) 2014-12-19 2017-08-29 诺维信公司 蛋白酶变体以及对其进行编码的多核苷酸
US11518987B2 (en) 2014-12-19 2022-12-06 Novozymes A/S Protease variants and polynucleotides encoding same
US11198860B2 (en) 2014-12-19 2021-12-14 Novozymes A/S Protease variants and polynucleotides encoding same
EP3280791A1 (de) 2015-04-10 2018-02-14 Novozymes A/S Waschverfahren, verwendung von dnase und waschmittelzusammensetzung
EP3280800A1 (de) 2015-04-10 2018-02-14 Novozymes A/S Reinigungsmittelzusammensetzung
WO2017050441A1 (en) 2015-09-24 2017-03-30 Unilever N.V. Substrate washing device
CN108603187A (zh) * 2015-11-24 2018-09-28 诺维信公司 具有蛋白酶活性的多肽以及编码它们的多核苷酸
WO2017207762A1 (en) 2016-06-03 2017-12-07 Novozymes A/S Subtilase variants and polynucleotides encoding same
US20200199801A1 (en) 2017-06-09 2020-06-25 Conopco, Inc., D/B/A Unilever Laundry liquid dispensing system
WO2020099490A1 (en) 2018-11-14 2020-05-22 Novozymes A/S Oral care composition comprising enzymes
EP3890507A1 (de) 2018-12-05 2021-10-13 Novozymes A/S Verwendung eines enzymgranulats
WO2021018751A1 (en) 2019-07-26 2021-02-04 Novozymes A/S Enzymatic treatment of paper pulp
CN112852788B (zh) * 2019-11-26 2022-10-11 江南大学 一种碱性底物选择性提高的枯草蛋白酶e突变体及其应用
EP4069813B1 (de) 2019-12-05 2023-09-13 Unilever IP Holdings B.V. Biologisch abbaubare verpackung mit wasserlöslichen kapseln
CN115917081A (zh) 2020-05-29 2023-04-04 诺维信公司 在制浆或造纸工艺中控制粘液的方法
KR20230057391A (ko) 2020-08-24 2023-04-28 노보자임스 에이/에스 프럭타나제를 포함하는 구강 관리 조성물
BR112023005128A2 (pt) * 2020-09-22 2023-04-25 Basf Se Composição, composição de detergente, método para prover uma composição de detergente com estabilidade e/ou desempenho de lavagem melhorados, e, uso de uma composição
BR112023023757A2 (pt) 2021-05-14 2024-01-30 Unilever Ip Holdings B V Embalagem
GB2607442A (en) 2021-05-14 2022-12-07 Unilever Global Ip Ltd Package containing water-soluble capsules
WO2022238440A1 (en) 2021-05-14 2022-11-17 Unilever Ip Holdings B.V. Package containing water-soluble capsules
FR3122869A1 (fr) 2021-05-14 2022-11-18 Unilever Ip Holdings B.V. Conditionnement contenant des capsules solubles dans l’eau
WO2022238449A1 (en) 2021-05-14 2022-11-17 Unilever Ip Holdings B.V. Package containing water-soluble capsules
WO2022238442A1 (en) 2021-05-14 2022-11-17 Unilever Ip Holdings B.V. Package containing water-soluble capsules
FR3123330A1 (fr) 2021-05-25 2022-12-02 Unilever Ip Holdings B.V. Conditionnement contenant des capsules solubles dans l'eau
EP4355868A1 (de) 2021-06-16 2024-04-24 Novozymes A/S Verfahren zur schleimkontrolle in einem zellstoff- oder papierherstellungsverfahren
WO2023078594A1 (en) 2021-11-05 2023-05-11 Unilever Ip Holdings B.V. Package containing water-soluble capsules
CN118355100A (zh) 2021-12-07 2024-07-16 联合利华知识产权控股有限公司 含有水溶性胶囊的包装
DE202022102651U1 (de) 2022-05-13 2022-05-30 Unilever Global Ip Limited Wasserlösliche Kapseln enthaltende Packung
DE202022102650U1 (de) 2022-05-13 2022-06-13 Unilever Global Ip Limited Wasserlösliche Kapseln enthaltende Packung
WO2024121070A1 (en) * 2022-12-05 2024-06-13 Novozymes A/S Protease variants and polynucleotides encoding same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234445A (de) 1967-10-03 1971-06-03
US3929887A (en) 1970-05-18 1975-12-30 Endo Lab Alkylenepoly(aralkylamines) and the salts thereof
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
US5013657A (en) * 1988-04-12 1991-05-07 Bryan Philip N Subtilisin mutations
JPS63502959A (ja) * 1986-02-12 1988-11-02 ジェネックス、コ−ポレ−ション 突然変異誘発及びスクリ−ニング方法並びに生成物
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) * 1988-01-07 1988-01-07 Novo Industri As Enzymer

Also Published As

Publication number Publication date
KR100258459B1 (en) 2000-06-01
FI916050A0 (fi) 1991-12-20
JP2002272488A (ja) 2002-09-24
DK0945502T3 (da) 2005-08-22
ATE362525T1 (de) 2007-06-15
FI990023A (fi) 1999-01-08
DE69034243T2 (de) 2008-01-24
EP1553173B1 (de) 2007-05-16
DE69033644T2 (de) 2001-05-10
DE69034241D1 (de) 2007-06-21
ATE196774T1 (de) 2000-10-15
JP2002315591A (ja) 2002-10-29
EP1555314A3 (de) 2006-01-25
EP1553174B1 (de) 2007-05-09
JPH04505856A (ja) 1992-10-15
AU5956690A (en) 1991-01-17
EP0479870B1 (de) 2000-10-04
EP1553173A3 (de) 2006-01-25
DE69034241T2 (de) 2008-01-10
ES2152209T3 (es) 2001-02-01
EP1553173A2 (de) 2005-07-13
JP3343115B2 (ja) 2002-11-11
EP0945502A1 (de) 1999-09-29
FI102907B (fi) 1999-03-15
EP0945502B1 (de) 2005-04-20
DE69034187D1 (de) 2005-05-25
EP1553174A3 (de) 2006-02-22
ATE361974T1 (de) 2007-06-15
KR920702719A (ko) 1992-10-06
ES2242314T3 (es) 2005-11-01
CA2062732C (en) 2000-05-23
ATE293687T1 (de) 2005-05-15
EP1555314B1 (de) 2009-09-30
WO1991000345A1 (en) 1991-01-10
EP0479870A1 (de) 1992-04-15
BR9007477A (pt) 1992-06-02
DE69034187T2 (de) 2006-03-09
EP1553174A2 (de) 2005-07-13
EP1555314A2 (de) 2005-07-20
DE945502T1 (de) 2002-10-17
ATE444357T1 (de) 2009-10-15
DE69034266D1 (de) 2009-11-12
DE69034243D1 (de) 2007-06-28
CA2062732A1 (en) 1990-12-27
DK316989D0 (da) 1989-06-26
DE69033644D1 (de) 2000-11-09
DK0479870T3 (da) 2001-04-17
FI990023A0 (fi) 1999-01-08
FI20031209A (fi) 2003-08-28
FI112500B (fi) 2003-12-15
JP3532902B2 (ja) 2004-05-31

Similar Documents

Publication Publication Date Title
DK0945502T3 (da) Muteret subtilisinprotease
BR9712473A (pt) Variantes de subtilase e composições
DE69839076D1 (de) Proteasevarianten und zusammensetzungen
DK305984D0 (da) Prokaryotiske carbonylhydrolaser, deres fremstilling og manipulering ved rekombinant teknik og deres anvendelse i vaskemidler
AU4773197A (en) Subtilase variants and compositions
AR001864A1 (es) Variantes de subtilasa un procedimiento para su obtención un proceso que comprende una mutación en el adn que codifica una subtilasa una secuencia de adn que codifica una subtilasa un vector y un huesped microbiano
DK1009795T3 (da) Detergentkompositioner indeholdende en mannanase og en protease
ES2174820T3 (es) Composiciones detergentes compactas con celulasa de alta actividad.
AR001863A1 (es) Una composición de detergente que comprende una variante de subtilasa
ES2061717T3 (es) Composiciones de limpieza conteniendo proteasas producidas por vibrio.
EP0199404A3 (en) Liquid detergents containing anionic surfactant, builder and proteolytic enzyme
ES2169052T3 (es) Preparados enzimaticos liquidos.
BR9811412A (pt) Variante de enzima subtilase tendo melhorado desempenho de lavagem em detergentes, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processos para produzir uma variante e para identificar uma variante de protease, composição, e, uso de uma variante de subtilase
BR9811396A (pt) Variante de enzima subtilase tendo melhorado desempenho de lavagem em detergentes, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processos para produzir uma variante e para identificar uma variante de protease, composição, e, uso de uma variante de subtilase