FI101704B1 - Förfarande för framställning av nya bis[4-(2,6-dialkyl)fenol]silanderivat användbara som antiaterosklerotiska medel - Google Patents
Förfarande för framställning av nya bis[4-(2,6-dialkyl)fenol]silanderivat användbara som antiaterosklerotiska medelInfo
- Publication number
- FI101704B1 FI101704B1 FI913253A FI913253A FI101704B1 FI 101704 B1 FI101704 B1 FI 101704B1 FI 913253 A FI913253 A FI 913253A FI 913253 A FI913253 A FI 913253A FI 101704 B1 FI101704 B1 FI 101704B1
- Authority
- FI
- Finland
- Prior art keywords
- phenol
- dialkyl
- preparation
- silane derivatives
- antiatherosclerotic agents
- Prior art date
Links
- 230000000879 anti-atherosclerotic effect Effects 0.000 title abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title 1
- 150000004756 silanes Chemical class 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003859 lipid peroxidation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Fats And Perfumes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54805190A | 1990-07-05 | 1990-07-05 | |
US54805190 | 1990-07-05 | ||
US69668491A | 1991-05-07 | 1991-05-07 | |
US69668491 | 1991-05-07 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI913253A0 FI913253A0 (fi) | 1991-07-04 |
FI913253A FI913253A (fi) | 1992-01-06 |
FI101704B FI101704B (sv) | 1998-08-14 |
FI101704B1 true FI101704B1 (sv) | 1998-08-14 |
Family
ID=27068750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913253A FI101704B1 (sv) | 1990-07-05 | 1991-07-04 | Förfarande för framställning av nya bis[4-(2,6-dialkyl)fenol]silanderivat användbara som antiaterosklerotiska medel |
Country Status (20)
Country | Link |
---|---|
US (1) | US5281738A (sv) |
EP (1) | EP0464844B1 (sv) |
JP (1) | JP2963557B2 (sv) |
KR (1) | KR0186006B1 (sv) |
CN (1) | CN1029614C (sv) |
AT (1) | ATE132154T1 (sv) |
AU (1) | AU639807B2 (sv) |
CA (1) | CA2046050C (sv) |
DE (1) | DE69115771T2 (sv) |
DK (1) | DK0464844T3 (sv) |
ES (1) | ES2084062T3 (sv) |
FI (1) | FI101704B1 (sv) |
GR (1) | GR3018926T3 (sv) |
HU (1) | HU210695B (sv) |
IE (1) | IE72155B1 (sv) |
IL (1) | IL98711A (sv) |
NO (1) | NO179914C (sv) |
NZ (1) | NZ238807A (sv) |
PT (1) | PT98219B (sv) |
TW (1) | TW213919B (sv) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2707989B1 (fr) * | 1993-07-22 | 1995-10-13 | Pf Medicament | Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant. |
US5677291A (en) * | 1993-12-10 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
EP1468692B1 (en) * | 1993-12-10 | 2006-04-26 | Merrell Pharmaceuticals Inc. | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma |
US5449679A (en) * | 1994-07-29 | 1995-09-12 | Leonard; Robert J. | Process and products for reducing biological fluid levels of a lipid soluble waste |
US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
US6114572A (en) * | 1996-11-20 | 2000-09-05 | Hoechst Marion Roussel, Inc. | Substituted phenols and thiophenols useful as antioxidant agents |
US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
AUPO787897A0 (en) * | 1997-07-14 | 1997-08-07 | Cardiac Crc Nominees Pty Limited | Silicon-containing chain extenders |
KR102067384B1 (ko) * | 2011-12-30 | 2020-01-17 | 다우 실리콘즈 코포레이션 | 고체 조명 장치 및 형성 방법 |
CN104817581B (zh) * | 2015-05-07 | 2018-01-02 | 衢州学院 | 一种含硅二元酚及其制备方法 |
KR20220145860A (ko) * | 2020-02-24 | 2022-10-31 | 다우 글로벌 테크놀로지스 엘엘씨 | 금속-리간드 착물 촉매의 헤테로원자-가교 전구체의 비-극저온 합성 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3506674A (en) * | 1967-07-03 | 1970-04-14 | Gen Electric | Certain pyridyl thio ether silanes |
US3853776A (en) * | 1972-09-29 | 1974-12-10 | Monsanto Co | Low pour point fluids and blends containing same |
US3801617A (en) * | 1973-07-24 | 1974-04-02 | Nasa | Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids |
AR208203A1 (es) * | 1974-09-10 | 1976-12-09 | Cortial | Proceso para la preparacion de acido p-trialquilsilil benzoico y derivados del mismo |
JPS61263988A (ja) * | 1985-05-16 | 1986-11-21 | Shionogi & Co Ltd | シリル置換エ−テル類および殺虫・殺ダニ剤 |
US4636573A (en) * | 1985-09-09 | 1987-01-13 | Pastor Stephen D | Hindered silicon ester stabilizers |
US4804653A (en) * | 1986-05-02 | 1989-02-14 | Uniroyal Chemical Company, Inc. | Thiomethyl-substituted organosilane compounds and their use as pesticides |
US4783495A (en) * | 1987-11-20 | 1988-11-08 | Ciba-Geigy Corporation | (Hydroxyphenyl) silane stabilizers |
US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
DE4031001A1 (de) * | 1990-10-01 | 1992-04-02 | Hoechst Ag | Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen |
-
1991
- 1991-07-01 NZ NZ238807A patent/NZ238807A/en unknown
- 1991-07-02 CA CA002046050A patent/CA2046050C/en not_active Expired - Lifetime
- 1991-07-02 IL IL9871191A patent/IL98711A/en not_active IP Right Cessation
- 1991-07-02 TW TW080105145A patent/TW213919B/zh active
- 1991-07-03 AU AU80114/91A patent/AU639807B2/en not_active Ceased
- 1991-07-03 KR KR1019910011223A patent/KR0186006B1/ko not_active IP Right Cessation
- 1991-07-04 DE DE69115771T patent/DE69115771T2/de not_active Expired - Lifetime
- 1991-07-04 HU HU912271A patent/HU210695B/hu not_active IP Right Cessation
- 1991-07-04 NO NO912629A patent/NO179914C/no unknown
- 1991-07-04 CN CN91104474A patent/CN1029614C/zh not_active Expired - Fee Related
- 1991-07-04 IE IE234191A patent/IE72155B1/en not_active IP Right Cessation
- 1991-07-04 PT PT98219A patent/PT98219B/pt not_active IP Right Cessation
- 1991-07-04 JP JP3189499A patent/JP2963557B2/ja not_active Expired - Lifetime
- 1991-07-04 FI FI913253A patent/FI101704B1/sv active
- 1991-07-04 ES ES91111220T patent/ES2084062T3/es not_active Expired - Lifetime
- 1991-07-04 AT AT91111220T patent/ATE132154T1/de not_active IP Right Cessation
- 1991-07-05 DK DK91111220.9T patent/DK0464844T3/da active
- 1991-07-05 EP EP91111220A patent/EP0464844B1/en not_active Expired - Lifetime
-
1992
- 1992-09-02 US US07/939,561 patent/US5281738A/en not_active Expired - Lifetime
-
1996
- 1996-02-07 GR GR960400332T patent/GR3018926T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO912630D0 (no) | Fremgangsmaate for fremstilling av nye 2,6-dialkyl-4-silyl-fenoler. | |
FI931708A0 (fi) | Herbicida substituerade aryl-haloalkylpyrazoler | |
NO914092D0 (no) | Fremgangsmaate for fremstilling av mercaptoacetylamidderivater | |
FI101704B1 (sv) | Förfarande för framställning av nya bis[4-(2,6-dialkyl)fenol]silanderivat användbara som antiaterosklerotiska medel | |
ES2071227T3 (es) | Composicion para gotas para los ojos. | |
DE69705480D1 (de) | Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung | |
FI945839A0 (sv) | Vattenhaltig lösning av inklusionskomplex av bensotiofenföreningar och vattenlösliga cyklodextriner, och farmaceutiska kompositioner därav samt metoder | |
EP0330041A3 (de) | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung und ihre Verwendung | |
PT90883A (pt) | Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem | |
HU906010D0 (en) | New substituted alkyl-piperidine derivatives | |
NO842345L (no) | Heksahydropyrrolo(2,1-a)isoquinolin-derivater. | |
ES2044883T3 (es) | Procedimiento para preparar quinoxalinas sustituidas. | |
GR880100452A (el) | Μυκητοκτονες συνθεσεις με βαση νικοτινικα παραγωγα,νεα νικοτινικα παραγωγα και η παρασκευη τους | |
ZA915075B (en) | Novel bis(4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents | |
ES2107281T3 (es) | Nuevos derivados de acetaldehido, su procedimiento de preparacion y su aplicacion. | |
ES545355A0 (es) | Procedimiento para preparar esteres de acidos a-aciloximino-alcanfosfonicos (y-fosfinicos) |