PT90883A - Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem - Google Patents

Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem

Info

Publication number
PT90883A
PT90883A PT90883A PT9088389A PT90883A PT 90883 A PT90883 A PT 90883A PT 90883 A PT90883 A PT 90883A PT 9088389 A PT9088389 A PT 9088389A PT 90883 A PT90883 A PT 90883A
Authority
PT
Portugal
Prior art keywords
bridge
benzazepines
tetrahydro
preparing
pharmaceutical compositions
Prior art date
Application number
PT90883A
Other languages
English (en)
Other versions
PT90883B (pt
Inventor
Peter Hongaard Andersen
Louis Brammer Hansen
Peter Faarup
Frederik Christian Gronvald
Erling Guddal
Erik Bardum Nielsen
Kristian Tage Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PT90883A publication Critical patent/PT90883A/pt
Publication of PT90883B publication Critical patent/PT90883B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT90883A 1988-06-15 1989-06-15 Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem PT90883B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK325188A DK325188D0 (da) 1988-06-15 1988-06-15 Hidtil ukendte benzazepinderivater

Publications (2)

Publication Number Publication Date
PT90883A true PT90883A (pt) 1989-12-29
PT90883B PT90883B (pt) 1994-12-30

Family

ID=8120790

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90883A PT90883B (pt) 1988-06-15 1989-06-15 Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem

Country Status (15)

Country Link
US (2) US5010074A (pt)
EP (1) EP0347672B1 (pt)
JP (1) JP2769718B2 (pt)
AT (1) ATE102188T1 (pt)
AU (1) AU622911B2 (pt)
CA (1) CA1317938C (pt)
DE (1) DE68913367T2 (pt)
DK (1) DK325188D0 (pt)
ES (1) ES2061794T3 (pt)
FI (1) FI93354C (pt)
IE (1) IE891932L (pt)
IL (1) IL90533A (pt)
NO (1) NO173865C (pt)
NZ (1) NZ229521A (pt)
PT (1) PT90883B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
US5158948A (en) * 1990-11-16 1992-10-27 Abbott Laboratories Tetracyclic spirobenzazepine dopamine antagonists
DK23392D0 (da) * 1992-02-24 1992-02-24 Novo Nordisk As Heterocykliske forbindelser, deres anvendelse og fremstilling
US5470850A (en) * 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
PL189822B1 (pl) * 1997-03-12 2005-09-30 Addex Pharmaceuticals Sa Zastosowanie (+)-5-(2,3-dihydrobenzofuran-7-ylo)-7-hydroksy-3-metylo-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepiny lub jej farmaceutycznie dopuszczalnej soli do wytwarzania kompozycji farmaceutycznej
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
CN1688584A (zh) * 2002-08-29 2005-10-26 先灵公司 治疗肥胖和中枢神经系统疾病的选择性d1/d5受体拮抗剂
EP1572215B1 (en) 2002-12-20 2009-09-02 Glaxo Group Limited Benzo[d]azepine derivatives for the treatment of neurological disorders
US7504391B2 (en) * 2003-05-22 2009-03-17 Schering Corporation Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792042B (en) * 1978-05-08 1980-05-28 Scherico Ltd Substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4327023A (en) * 1980-01-31 1982-04-27 Smithkline Corporation Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
KR900007781B1 (ko) * 1986-01-16 1990-10-20 쉐링 코포레이션 융합된 벤즈아제핀
EP0244088A3 (en) * 1986-04-03 1989-03-15 Smithkline Beecham Corporation 1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders

Also Published As

Publication number Publication date
EP0347672A1 (en) 1989-12-27
JP2769718B2 (ja) 1998-06-25
ATE102188T1 (de) 1994-03-15
NO892476D0 (no) 1989-06-14
FI892946A0 (fi) 1989-06-15
CA1317938C (en) 1993-05-18
NO173865B (no) 1993-11-08
PT90883B (pt) 1994-12-30
AU622911B2 (en) 1992-04-30
IL90533A (en) 1994-05-30
DE68913367T2 (de) 1994-06-01
NO892476L (no) 1989-12-18
EP0347672B1 (en) 1994-03-02
AU3635989A (en) 1989-12-21
IE891932L (en) 1989-12-15
FI93354B (fi) 1994-12-15
DE68913367D1 (de) 1994-04-07
IL90533A0 (en) 1990-01-18
NO173865C (no) 1994-02-16
FI93354C (fi) 1995-03-27
JPH0240364A (ja) 1990-02-09
US5025009A (en) 1991-06-18
DK325188D0 (da) 1988-06-15
FI892946A (fi) 1989-12-16
ES2061794T3 (es) 1994-12-16
US5010074A (en) 1991-04-23
NZ229521A (en) 1991-12-23

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940603

PC3A Transfer or assignment

Free format text: 20010821 CENES LIMITED GB

PC3A Transfer or assignment

Free format text: ADDEX PHARMACEUTICALS, SA. CH

Effective date: 20030505

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090615