ES8802538A1 - Un metodo de producir una proteina capaz de modular la actividad fisiologica de celulas que tienen un receptor de diazepam - Google Patents

Un metodo de producir una proteina capaz de modular la actividad fisiologica de celulas que tienen un receptor de diazepam

Info

Publication number
ES8802538A1
ES8802538A1 ES557400A ES557400A ES8802538A1 ES 8802538 A1 ES8802538 A1 ES 8802538A1 ES 557400 A ES557400 A ES 557400A ES 557400 A ES557400 A ES 557400A ES 8802538 A1 ES8802538 A1 ES 8802538A1
Authority
ES
Spain
Prior art keywords
polypeptides
antibodies
derivable
brain
polypeptide factors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557400A
Other languages
English (en)
Other versions
ES557400A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/694,712 external-priority patent/US4714683A/en
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES8802538A1 publication Critical patent/ES8802538A1/es
Publication of ES557400A0 publication Critical patent/ES557400A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y10S436/813—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Abstract

CONSISTE EN UN CULTIVO DE CELULAS BACTERIANAS EN UN MEDIO ADECUADO PARA SU CRECIMIENTO, A UNA TEMPERATURA ENTRE 20-40GC. ESTAS CELULAS CONTIENEN UN GEN QUE CODIFICA UNA SECUENCIA DE POLIPEPTIDOS ENTRE 15-125 AMINOACIDOS, TENIENDO UN SITIO EPITOPICO DE REACCION CRUZADA CON UN POLIPEPTIDO, PRESENTE EN EL CEREBRO DE MAMIFERO, QUE SE FIJA ESPECIFICAMENTE AL RECEPTOR DE DIAZEPAR IN VITRO. DICHO POLIPEPTIDO, INCLUYE AL MENOS UNA DE LAS SECUENCIAS PEPTIDICAS CORRESPONDIENTES A LA FORMULA (I), DONDE: AAA AMINOACIDO AROMATICO; AAB Y AAC AMINOACIDOS NEUTROS DIFATICOS; AAP REPRESENTA INDEPENDIENTEMENTE UN AMINOACIDO DIFATICO; X ES DE 1-3 AMINOACIDOS Y X DE 0-1 AMINOACIDO. EN EL METODO TAMBIEN SE INCLUYE LA SEPARACION DE LAS CELULAS BACTERIANAS DEL MEDIO DE CRECIMIENTO. SI LA PROTEINA QUEDA RETENIDA INTRACELULARMENTE EN LAS CELULAS BACTERIANAS, SE LISAN, SEPARANDO PARTICULAS Y PRODUCTOS SOLUBLES QUE CONTIENEN LA PROTEINA; SI LA PROTEINA ES SECRETADA POR LAS CELULAS BACTERIANAS, SE RETIENE EL MEDIO DE CRECIMIENTO QUE CONTIENE LA PROTEINA. *FORMULA*
ES557400A 1985-01-25 1987-02-16 Un metodo de producir una proteina capaz de modular la actividad fisiologica de celulas que tienen un receptor de diazepam Expired ES8802538A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/694,712 US4714683A (en) 1985-01-25 1985-01-25 Polypeptide tumor inhibitors and antibodies thereto
US06/766,864 US4806492A (en) 1985-01-25 1985-08-15 Polypeptide tumor inhibitors and antibodies thereto

Publications (2)

Publication Number Publication Date
ES8802538A1 true ES8802538A1 (es) 1988-07-01
ES557400A0 ES557400A0 (es) 1988-07-01

Family

ID=27105426

Family Applications (2)

Application Number Title Priority Date Filing Date
ES551233A Expired ES8705897A1 (es) 1985-01-25 1986-01-24 Un metodo para producir una proteina capaz de modular la actividad fisiologica de celulas que tienen receptores de diazepam.
ES557400A Expired ES8802538A1 (es) 1985-01-25 1987-02-16 Un metodo de producir una proteina capaz de modular la actividad fisiologica de celulas que tienen un receptor de diazepam

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES551233A Expired ES8705897A1 (es) 1985-01-25 1986-01-24 Un metodo para producir una proteina capaz de modular la actividad fisiologica de celulas que tienen receptores de diazepam.

Country Status (8)

Country Link
US (2) US4777270A (es)
EP (1) EP0210233A4 (es)
JP (9) JPH064672B2 (es)
AU (1) AU589598B2 (es)
ES (2) ES8705897A1 (es)
MX (1) MX163576B (es)
PT (1) PT81916B (es)
WO (2) WO1993013089A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011777A (en) * 1985-01-25 1991-04-30 Oncogen Vectors encoding brain derivable polypeptide factors
US4935442A (en) * 1985-02-28 1990-06-19 Pfizer Inc. Tetrahydrofuran-containing macrocyclic polyether carboxylic acids
JP2690956B2 (ja) * 1987-08-22 1997-12-17 三井東圧化学株式会社 生体由来のタンパク質
US5065006A (en) * 1988-10-14 1991-11-12 Matsushita Electric Industrial Co., Inc. Image sensors with simplified chip mounting
DK169306B1 (da) * 1989-06-14 1994-10-10 Af 18 Juni 1990 As Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
US5142068A (en) * 1989-10-06 1992-08-25 Virginia Tech Intellectual Properties, Inc. Mono- and di(functionally-substituted phenylene) semi-rigid crowns and processes for making
US5648340A (en) * 1991-10-31 1997-07-15 Barnea; Eytan R. Gestational agents for controlling cell proliferation
US5160483A (en) * 1991-05-07 1992-11-03 The University Of Tennessee Research Corporation Fragment of TNF-α for promoting wound healing
US5758132A (en) * 1995-03-29 1998-05-26 Telefonaktiebolaget Lm Ericsson Clock control system and method using circuitry operating at lower clock frequency for selecting and synchronizing the switching of higher frequency clock signals
JP2003527831A (ja) * 1999-10-05 2003-09-24 キュラジェン コーポレイション エンドゼピン様ポリペプチドおよびエンドゼピン様ポリペプチドをコードするポリヌクレオチド
WO2006005590A1 (en) * 2004-07-12 2006-01-19 Geneprot Inc. Polypeptide for the treatment of neurological disorders

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SU732270A1 (ru) * 1977-07-07 1980-05-05 Институт химии Уральского научного центра АН СССР Комплексные соединени дибензо-18- краун-6 с сол ми металлов как катализаторы реакции переэтерификации и поликонденсации в синтезе полиэтилентерефталата
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Also Published As

Publication number Publication date
US4777270A (en) 1988-10-11
ES8705897A1 (es) 1987-05-16
JPH03178999A (ja) 1991-08-02
JPH03163098A (ja) 1991-07-15
JPH03169892A (ja) 1991-07-23
AU5359586A (en) 1986-08-13
WO1986004239A1 (en) 1986-07-31
US4806492A (en) 1989-02-21
WO1993013089A1 (en) 1993-07-08
JPH03172183A (ja) 1991-07-25
EP0210233A1 (en) 1987-02-04
ES557400A0 (es) 1988-07-01
EP0210233A4 (en) 1989-11-07
JPH03155787A (ja) 1991-07-03
AU589598B2 (en) 1989-10-19
JPH03164183A (ja) 1991-07-16
JPH03169896A (ja) 1991-07-23
PT81916B (pt) 1987-11-30
PT81916A (en) 1986-02-01
JPS62501841A (ja) 1987-07-23
ES551233A0 (es) 1987-05-16
MX163576B (es) 1992-06-03
JPH064672B2 (ja) 1994-01-19
JPH03193800A (ja) 1991-08-23

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Effective date: 20020603