ES2002915A6 - Un procedimiento para la preparacion de un peptido de veneno de serpiente que detiene el crecimiento. - Google Patents

Un procedimiento para la preparacion de un peptido de veneno de serpiente que detiene el crecimiento.

Info

Publication number
ES2002915A6
ES2002915A6 ES8603138A ES8603138A ES2002915A6 ES 2002915 A6 ES2002915 A6 ES 2002915A6 ES 8603138 A ES8603138 A ES 8603138A ES 8603138 A ES8603138 A ES 8603138A ES 2002915 A6 ES2002915 A6 ES 2002915A6
Authority
ES
Spain
Prior art keywords
snake venom
growth arresting
peptide
venom growth
arresting peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8603138A
Other languages
English (en)
Inventor
Hans Marquardt
George J Todaro
Daniel R Twardzik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of ES2002915A6 publication Critical patent/ES2002915A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/856—Snakes; venom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE UN PEPTIDO DE VENENO DE SERPIENTE, QUE DETIENE EL CRECIMIENTO DE FORMULA GENERAL (I) DONDE PP1 ES EL EXTREMO N Y PUEDE SER H O UNA CADENA DE 1 A 20 AMINOACIDOS; PP2 ES EL EXTREMO C Y PUEDE SER )OH O UNA CADENA DE 1 A 20 AMINOACIDOS; LAS LETRAS INDIVIDUALES TIENEN EL SIGNIFICADO DEL CODIGO DE AMINOACIDOS DE UNA LETRA; AA4-AA39 SON AMINOACIDOS, ALIFATICOS, AROMATICOS PUDIENDO ESTAR EL EXTREMO N BLOQUEADO O NO. SE RELACIONAN CON UNA TOXINA AISLADA DEL VENENO DE LA SERPIENTE CROTALUS ATROX. EL PROCEDIMIENTO COMPRENDE LA PURIFICACION DEL PEPTIDO TOXICO MEDIANTE FILTRACION EN GEL O HPLC. OPCIONALMENTE, EL PEPTIDO PUEDE UNIRSE MEDIANTE GRUPOS FUNCIONALES A ELEMENTOS DE PAR DE UNION ESPECIFICA, COMO LIGANDOS, RECEPTORES O ANTICUERPOS, PARA FORMAR CONJUGADOS. ESTOS PEPTIDOS SON CITOTOXICOS, INHIBEN EL CRECIMIENTO CELULAR, PUDIENDOSE APLICAR EN TERAPIA INHIBITORIA DEL CRECIMIENTO DE CELULAS MALIGNAS.
ES8603138A 1985-11-22 1986-11-21 Un procedimiento para la preparacion de un peptido de veneno de serpiente que detiene el crecimiento. Expired ES2002915A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/801,019 US4731439A (en) 1985-11-22 1985-11-22 Snake venom growth arresting peptide

Publications (1)

Publication Number Publication Date
ES2002915A6 true ES2002915A6 (es) 1988-10-01

Family

ID=25179974

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8603138A Expired ES2002915A6 (es) 1985-11-22 1986-11-21 Un procedimiento para la preparacion de un peptido de veneno de serpiente que detiene el crecimiento.

Country Status (20)

Country Link
US (1) US4731439A (es)
KR (1) KR900006575B1 (es)
CN (1) CN86108593A (es)
AU (3) AU6556386A (es)
BE (1) BE905790A (es)
CH (1) CH670451A5 (es)
DE (1) DE3639796A1 (es)
DK (1) DK560986A (es)
ES (1) ES2002915A6 (es)
FI (1) FI864715A (es)
FR (1) FR2590576A1 (es)
GB (1) GB2185023B (es)
GR (1) GR862788B (es)
IT (1) IT1207580B (es)
LU (1) LU86683A1 (es)
NL (1) NL8602939A (es)
PT (1) PT83790B (es)
SE (1) SE8604991L (es)
YU (1) YU199586A (es)
ZA (1) ZA868849B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5939890A (en) * 1989-06-07 1991-01-07 Genentech Inc. Platelet aggregation inhibitors and related molecules
WO1991001740A1 (en) * 1989-08-05 1991-02-21 Varánusz Gm Process for producing pharmacosmetics
US5232911A (en) * 1990-01-03 1993-08-03 Ventech Research Inc. Mixture of a non-covalent heterodimer complex and a basic amphiphatic peptide as cytotoxic agent
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
DE4433890C2 (de) * 1994-09-22 1999-02-18 Deutsches Krebsforsch Konjugat aus einem Wirkstoff und einem nicht als körperfremd angesehenen, nativen Protein
SG129211A1 (en) * 1997-11-06 2007-02-26 Univ Singapore Therapeutic molecules
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
BRPI0501037B8 (pt) * 2005-03-18 2021-07-27 Fund De Amparo A Pesquisa Do Estado De Sao Paulo uso de crotamina e composição
US20060234934A1 (en) * 2005-04-15 2006-10-19 Kilmon Joseph A Composition and Method for Selective Cytostasis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (ja) * 1977-02-10 1983-08-08 大塚製薬株式会社 抗体の製造方法
US4220722A (en) * 1978-02-10 1980-09-02 Syva Company Method for conjugating to polyamino compounds employing haloacyl groups and compositions prepared thereby
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4500637A (en) * 1982-07-19 1985-02-19 The United States Of America As Represented By The Department Of Health And Human Services Prevention of graft versus host disease following bone marrow transplantation

Also Published As

Publication number Publication date
KR870005014A (ko) 1987-06-04
PT83790A (en) 1986-12-01
DE3639796A1 (de) 1987-07-09
AU6667590A (en) 1991-03-28
IT1207580B (it) 1989-05-25
CH670451A5 (es) 1989-06-15
LU86683A1 (fr) 1987-06-26
GB2185023A (en) 1987-07-08
US4731439A (en) 1988-03-15
AU6560986A (en) 1987-05-28
NL8602939A (nl) 1987-06-16
BE905790A (fr) 1987-05-19
GR862788B (en) 1987-03-26
DK560986A (da) 1987-05-23
YU199586A (en) 1988-06-30
SE8604991L (sv) 1987-05-23
IT8622425A0 (it) 1986-11-21
GB8627710D0 (en) 1986-12-17
DK560986D0 (da) 1986-11-21
CN86108593A (zh) 1987-09-30
AU6556386A (en) 1987-05-28
PT83790B (pt) 1989-09-14
SE8604991D0 (sv) 1986-11-21
ZA868849B (en) 1987-07-29
FR2590576A1 (fr) 1987-05-29
FI864715A (fi) 1987-05-23
GB2185023B (en) 1990-08-29
FI864715A0 (fi) 1986-11-19
KR900006575B1 (ko) 1990-09-13

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