ES8801219A1 - Procedimiento para preparar 5-pririmidin-carboxamidas sustituidas con actividad anti-leucemia. - Google Patents
Procedimiento para preparar 5-pririmidin-carboxamidas sustituidas con actividad anti-leucemia.Info
- Publication number
- ES8801219A1 ES8801219A1 ES557683A ES557683A ES8801219A1 ES 8801219 A1 ES8801219 A1 ES 8801219A1 ES 557683 A ES557683 A ES 557683A ES 557683 A ES557683 A ES 557683A ES 8801219 A1 ES8801219 A1 ES 8801219A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- thienylmethyl
- naphthylmethyl
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 5-PIRIMIDINCARBOXAMIDAS, Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I). COMPRENDE LA REACCION DE 4,6-DIHIDROXIPIRIMIDINA, O UNA 4,6-DIHIDROXI-2-ALCOXIPIRIMIDINA, CON FENILISOCIANATO SUSTITUIDO, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O ALCOXI C1-4, R3 Y R4 SON HIDROGENO O FLUOR Y R2 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTI-LEUCEMICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/725,736 US4636508A (en) | 1985-04-22 | 1985-04-22 | 5-pyrimidinecarboxyamides and treatment of leukemia therewith |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801219A1 true ES8801219A1 (es) | 1987-12-16 |
| ES557683A0 ES557683A0 (es) | 1987-12-16 |
Family
ID=24915762
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554245A Expired ES8800671A1 (es) | 1985-04-22 | 1986-04-22 | Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividad anti-leucemia |
| ES557683A Expired ES8801219A1 (es) | 1985-04-22 | 1987-08-19 | Procedimiento para preparar 5-pririmidin-carboxamidas sustituidas con actividad anti-leucemia. |
| ES557684A Expired ES8801220A1 (es) | 1985-04-22 | 1987-08-19 | Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554245A Expired ES8800671A1 (es) | 1985-04-22 | 1986-04-22 | Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividad anti-leucemia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557684A Expired ES8801220A1 (es) | 1985-04-22 | 1987-08-19 | Procedimiento para preparar 5-pirimidin-carboxamidas sustituidas con actividadd anti-leucemia. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4636508A (es) |
| JP (1) | JPS6259264A (es) |
| CN (2) | CN1014990B (es) |
| AT (1) | AT391864B (es) |
| AU (3) | AU592559B2 (es) |
| BE (1) | BE904641A (es) |
| CA (1) | CA1274509A (es) |
| CH (1) | CH668970A5 (es) |
| DE (1) | DE3613447A1 (es) |
| DK (1) | DK182986A (es) |
| ES (3) | ES8800671A1 (es) |
| FR (1) | FR2580642B1 (es) |
| GB (1) | GB2174391B (es) |
| GR (1) | GR861024B (es) |
| IL (2) | IL78576A0 (es) |
| IT (1) | IT1214499B (es) |
| LU (1) | LU86403A1 (es) |
| NL (1) | NL8601023A (es) |
| NZ (1) | NZ215874A (es) |
| SE (1) | SE8601826L (es) |
| ZA (1) | ZA862630B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845217A (en) * | 1985-05-17 | 1989-07-04 | Uniroyal Chemical Ltd./Ltee | Purification of 5-pyrimidinecarboxamides |
| US4920126A (en) * | 1988-05-10 | 1990-04-24 | Uniroyal Chemical Ltd/Uniroyal Chemical Ltee | Barbituric acid derivative and treatment of leukemia and tumors therewith |
| FR2628741A1 (fr) * | 1988-07-14 | 1989-09-22 | Uniroyal Chemical Ltd | Nouveaux composes n-phenyl-5-pyrimidinecarboxamides et composition pharmaceutique les contenant utilisable pour induire la regression de la leucemie ou des tumeurs |
| FR2628869A1 (es) * | 1988-07-14 | 1989-09-22 | Uniroyal Chemical Ltd | |
| EP0430885A3 (en) * | 1989-12-01 | 1991-11-06 | Ciba-Geigy Ag | Anthelmintical compounds |
| WO2003035076A1 (en) * | 2001-10-26 | 2003-05-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Dihydroxypyrimidine carboxamide inhibitors of hiv integrase |
| US9428466B2 (en) * | 2013-11-13 | 2016-08-30 | Raymond P. Warrell, Jr. | Methods for reducing uric acid levels using barbiturate derivatives |
| US10093631B2 (en) * | 2014-02-14 | 2018-10-09 | Acquist Llc | Bifunctional compounds and use for reducing uric acid levels |
| EP3247704A4 (en) | 2015-01-22 | 2018-10-03 | Acquist LLC | Bifunctional compounds and use for reducing uric acid levels |
| TWI772309B (zh) | 2016-06-30 | 2022-08-01 | 美商艾克奎斯特有限責任公司 | 化合物及其於降低尿酸位準之用途(二) |
| WO2018009615A1 (en) | 2016-07-06 | 2018-01-11 | Acquist Llc | Compounds and their use for reducing uric acid levels |
| WO2018200571A1 (en) | 2017-04-25 | 2018-11-01 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1h-indene analogs and methods using same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670756A1 (de) * | 1966-10-05 | 1970-12-23 | Hoechst Ag | Verfahren zur Herstellung von 6-Amino-uracil-5-carbonamid-N-sulfonamiden |
| DE2405733C2 (de) * | 1974-02-07 | 1984-12-13 | Bayer Ag, 5090 Leverkusen | Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen |
| CH614944A5 (en) * | 1974-04-16 | 1979-12-28 | Sandoz Ag | Process for the preparation of novel pyrimidine derivatives |
| DE2719777A1 (de) * | 1976-05-06 | 1977-11-24 | Ciba Geigy Ag | Neue 5-phenylcarbamoyl-barbitursaeuren |
| PL103086B1 (pl) * | 1976-05-06 | 1979-05-31 | Ciba Geigy Ag | Srodek owadobojczy |
| US4283444A (en) * | 1978-09-12 | 1981-08-11 | Ciba-Geigy Corporation | Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds |
| US4349552A (en) * | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
| JPS5625166A (en) * | 1979-08-09 | 1981-03-10 | Banyu Pharmaceut Co Ltd | 5-fluorouracil derivative |
| JPS5843960A (ja) * | 1981-09-10 | 1983-03-14 | Shoichiro Ozaki | ５−フルオロウラシル誘導体，その製造法および制ガン剤 |
| DE3347795A1 (de) * | 1983-01-14 | 1985-08-01 | Ozaki, Shoichiro, Ehime | Neue 1-(n-substituierte carbamoyl)-5-fluorouracil-derivate und krebshemmende mittel, in denen sie als aktive bestandteile enthalten sind |
| JPS6012322A (ja) * | 1983-07-01 | 1985-01-22 | Toyota Motor Corp | 四リンク型サスペンシヨン |
| IL73840A (en) * | 1983-12-19 | 1988-11-15 | Uniroyal Chem Co Inc | 2-thio-5-(thio)carbamoyl barbituric acid derivatives,their preparation and pharmaceutical compositions containing them |
-
1985
- 1985-04-22 US US06/725,736 patent/US4636508A/en not_active Expired - Fee Related
-
1986
- 1986-04-08 ZA ZA862630A patent/ZA862630B/xx unknown
- 1986-04-16 GB GB08609244A patent/GB2174391B/en not_active Expired
- 1986-04-17 AT AT0101986A patent/AT391864B/de not_active IP Right Cessation
- 1986-04-18 NZ NZ215874A patent/NZ215874A/xx unknown
- 1986-04-18 GR GR861024A patent/GR861024B/el unknown
- 1986-04-18 IT IT8620153A patent/IT1214499B/it active
- 1986-04-18 CA CA000507040A patent/CA1274509A/en not_active Expired - Lifetime
- 1986-04-21 SE SE8601826A patent/SE8601826L/xx not_active Application Discontinuation
- 1986-04-21 DK DK182986A patent/DK182986A/da not_active Application Discontinuation
- 1986-04-21 CH CH1604/86A patent/CH668970A5/de not_active IP Right Cessation
- 1986-04-21 DE DE19863613447 patent/DE3613447A1/de active Granted
- 1986-04-21 FR FR8605715A patent/FR2580642B1/fr not_active Expired
- 1986-04-21 AU AU56418/86A patent/AU592559B2/en not_active Ceased
- 1986-04-21 BE BE0/216567A patent/BE904641A/fr not_active IP Right Cessation
- 1986-04-22 ES ES554245A patent/ES8800671A1/es not_active Expired
- 1986-04-22 IL IL78576A patent/IL78576A0/xx not_active IP Right Cessation
- 1986-04-22 NL NL8601023A patent/NL8601023A/nl not_active Application Discontinuation
- 1986-04-22 CN CN86102767A patent/CN1014990B/zh not_active Expired
- 1986-04-22 LU LU86403A patent/LU86403A1/fr unknown
- 1986-04-22 JP JP61093171A patent/JPS6259264A/ja active Pending
-
1987
- 1987-08-19 ES ES557683A patent/ES8801219A1/es not_active Expired
- 1987-08-19 ES ES557684A patent/ES8801220A1/es not_active Expired
-
1988
- 1988-06-11 CN CN88103648A patent/CN1038450A/zh active Pending
- 1988-06-12 IL IL8886711A patent/IL86711A0/xx unknown
- 1988-09-15 AU AU22195/88A patent/AU2219588A/en not_active Abandoned
- 1988-09-15 AU AU22196/88A patent/AU2219688A/en not_active Abandoned
Also Published As
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