ES8505935A1 - Procedimiento de preparacion de un derivado de la benzamida - Google Patents

Procedimiento de preparacion de un derivado de la benzamida

Info

Publication number
ES8505935A1
ES8505935A1 ES528012A ES528012A ES8505935A1 ES 8505935 A1 ES8505935 A1 ES 8505935A1 ES 528012 A ES528012 A ES 528012A ES 528012 A ES528012 A ES 528012A ES 8505935 A1 ES8505935 A1 ES 8505935A1
Authority
ES
Spain
Prior art keywords
alkyl
group
integer
hypolipidaemic
hypoglycaemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528012A
Other languages
English (en)
Other versions
ES528012A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Publication of ES8505935A1 publication Critical patent/ES8505935A1/es
Publication of ES528012A0 publication Critical patent/ES528012A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN DERIVADO DE LA BENZAMIDA.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE ORGANICO INERTE COMO DIMETILFORMAMIDA O DIOXANO, EN PRESENCIA DE UN AGENTE ACEPTOR DE ACIDO COMO TRIALQUILAMINA Y A UNA TEMPERATURA ENTRE 10 Y 50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO A, RADICAL ALQUILENO DE CADENA RECTA O RAMIFICADA DE C 1 A 6; R1, HAL, UN RADICAL MERCAPTO, AMINO Y OTROS; R4 UN RADICAL ALQUILO; M, 01,1,2 O 3, Y N Y P, 0,1 O 2.SE UTILIZAN PARA LA PREVENCION O TRATAMIENTOS DE DIABETES MELLITUS Y ESTADOS HIPERLIPOPROTEINOMICOS.
ES528012A 1982-08-24 1983-12-13 Procedimiento de preparacion de un derivado de la benzamida Granted ES528012A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8224296 1982-08-24

Publications (2)

Publication Number Publication Date
ES8505935A1 true ES8505935A1 (es) 1985-06-16
ES528012A0 ES528012A0 (es) 1985-06-16

Family

ID=10532494

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525099A Granted ES525099A0 (es) 1982-08-24 1983-08-23 Procedimiento de preparacion de un derivado de la benzamida
ES528012A Granted ES528012A0 (es) 1982-08-24 1983-12-13 Procedimiento de preparacion de un derivado de la benzamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525099A Granted ES525099A0 (es) 1982-08-24 1983-08-23 Procedimiento de preparacion de un derivado de la benzamida

Country Status (23)

Country Link
US (1) US4507315A (es)
JP (1) JPS5955873A (es)
KR (1) KR840005717A (es)
AT (1) ATA301083A (es)
AU (1) AU1818083A (es)
BE (1) BE897580A (es)
CA (1) CA1195993A (es)
CS (1) CS240973B2 (es)
DE (1) DE3330403A1 (es)
DK (1) DK386783A (es)
ES (2) ES525099A0 (es)
FI (1) FI832989A (es)
FR (1) FR2532310B1 (es)
GB (1) GB2126225B (es)
GR (1) GR78673B (es)
IL (1) IL69544A0 (es)
IT (1) IT1169775B (es)
LU (1) LU84974A1 (es)
NL (1) NL8302947A (es)
NO (1) NO833024L (es)
PT (1) PT77219B (es)
SE (1) SE8304545L (es)
ZA (1) ZA836191B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625144B2 (ja) * 1986-02-24 1994-04-06 四国化成工業株式会社 新規イミダゾール化合物及び該化合物の合成方法
US4916145A (en) * 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
US4886629A (en) * 1988-06-06 1989-12-12 Allied-Signal Inc. Process for the preparation of fluorinated benzene sulfonyl fluorides
CA2057324A1 (en) * 1990-12-18 1992-06-19 Lora Louise Fitch Benzamide and sulfonamide hypoglycemic agents
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
WO2001002361A1 (en) * 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated Beta-amino acid derivatives for the treatment of neurological diseases
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
CN101061116A (zh) * 2004-09-24 2007-10-24 詹森药业有限公司 磺酰胺化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3349124A (en) * 1957-05-20 1967-10-24 Pfizer & Co C Oral antidiabetic agent
BE756062A (fr) * 1969-09-11 1971-03-11 Boehringer Sohn Ingelheim Derives de 1,1,1-trichlorethane leurs procedes de fabrication et leur utilisation en tant que substances biocides
DE2500157C2 (de) * 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
DK148576A (da) * 1975-04-18 1976-10-19 Boehringer Mannheim Gmbh Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling
DE2517229A1 (de) * 1975-04-18 1976-10-28 Boehringer Mannheim Gmbh Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung
US4317915A (en) * 1976-08-23 1982-03-02 Hoffmann-La Roche Inc. Novel thiophene derivatives
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
US4245120A (en) * 1977-09-27 1981-01-13 American Cyanamid Company 4-(Monoalkylamino)benzene polycarboxylic acids
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel

Also Published As

Publication number Publication date
KR840005717A (ko) 1984-11-16
CS612483A2 (en) 1985-06-13
SE8304545D0 (sv) 1983-08-22
JPS5955873A (ja) 1984-03-31
IT1169775B (it) 1987-06-03
ZA836191B (en) 1984-04-25
CS240973B2 (en) 1986-03-13
ATA301083A (de) 1985-11-15
SE8304545L (sv) 1984-02-25
IT8322629A0 (it) 1983-08-24
FR2532310B1 (fr) 1986-01-10
FI832989A (fi) 1984-02-25
DK386783A (da) 1984-02-25
NL8302947A (nl) 1984-03-16
NO833024L (no) 1984-02-24
PT77219B (fr) 1986-02-04
CA1195993A (en) 1985-10-29
GR78673B (es) 1984-09-27
ES8502691A1 (es) 1985-01-16
GB2126225A (en) 1984-03-21
LU84974A1 (fr) 1984-03-23
BE897580A (fr) 1984-02-23
GB8322539D0 (en) 1983-09-21
DK386783D0 (da) 1983-08-23
US4507315A (en) 1985-03-26
ES525099A0 (es) 1985-01-16
FR2532310A1 (fr) 1984-03-02
FI832989A0 (fi) 1983-08-22
AU1818083A (en) 1984-03-01
IL69544A0 (en) 1983-11-30
ES528012A0 (es) 1985-06-16
DE3330403A1 (de) 1984-03-01
PT77219A (fr) 1983-09-01
GB2126225B (en) 1985-10-09

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