ES8607254A1 - Un procedimiento para la preparacion de derivados de n,n-pipericinilo disustituidos. - Google Patents
Un procedimiento para la preparacion de derivados de n,n-pipericinilo disustituidos.Info
- Publication number
- ES8607254A1 ES8607254A1 ES540901A ES540901A ES8607254A1 ES 8607254 A1 ES8607254 A1 ES 8607254A1 ES 540901 A ES540901 A ES 540901A ES 540901 A ES540901 A ES 540901A ES 8607254 A1 ES8607254 A1 ES 8607254A1
- Authority
- ES
- Spain
- Prior art keywords
- antipsychotic
- fluorophenylbutyl
- pyrimidinyl
- ring
- terminal carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 2
- UUQHPHIBIJWHMU-UHFFFAOYSA-N 2-[4-[4-(1-fluorocyclohexa-2,4-dien-1-yl)butyl]piperazin-1-yl]pyrimidine Chemical class FC1(CC=CC=C1)CCCCN1CCN(CC1)C1=NC=CC=N1 UUQHPHIBIJWHMU-UHFFFAOYSA-N 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 2
- 239000000164 antipsychotic agent Substances 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 239000003693 atypical antipsychotic agent Substances 0.000 abstract 1
- 229940127236 atypical antipsychotics Drugs 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000383 tetramethylene group Chemical class [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Legs For Furniture In General (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58658084A | 1984-03-06 | 1984-03-06 | |
| US06/683,309 US4605655A (en) | 1984-03-06 | 1984-12-18 | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607254A1 true ES8607254A1 (es) | 1986-05-16 |
| ES540901A0 ES540901A0 (es) | 1986-05-16 |
Family
ID=27079753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540901A Expired ES8607254A1 (es) | 1984-03-06 | 1985-03-04 | Un procedimiento para la preparacion de derivados de n,n-pipericinilo disustituidos. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4605655A (esLanguage) |
| KR (3) | KR920005113B1 (esLanguage) |
| AT (1) | AT390951B (esLanguage) |
| AU (1) | AU576555B2 (esLanguage) |
| BE (1) | BE901880A (esLanguage) |
| CA (1) | CA1256871A (esLanguage) |
| CH (1) | CH663022A5 (esLanguage) |
| CY (1) | CY1545A (esLanguage) |
| DE (1) | DE3507983A1 (esLanguage) |
| DK (1) | DK166149C (esLanguage) |
| ES (1) | ES8607254A1 (esLanguage) |
| FI (1) | FI84478C (esLanguage) |
| FR (1) | FR2560878B1 (esLanguage) |
| GB (1) | GB2155925B (esLanguage) |
| GR (1) | GR850561B (esLanguage) |
| HK (1) | HK82890A (esLanguage) |
| HU (1) | HU193949B (esLanguage) |
| IE (1) | IE58338B1 (esLanguage) |
| IT (1) | IT1183483B (esLanguage) |
| LU (1) | LU85796A1 (esLanguage) |
| MX (1) | MX9203177A (esLanguage) |
| MY (1) | MY102240A (esLanguage) |
| NL (1) | NL8500628A (esLanguage) |
| PT (1) | PT80058B (esLanguage) |
| SE (1) | SE462429B (esLanguage) |
| SG (1) | SG35590G (esLanguage) |
| ZA (1) | ZA851486B (esLanguage) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2104509A1 (es) * | 1995-06-13 | 1997-10-01 | Ferrer Int | Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina. |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| US4677104A (en) * | 1985-05-06 | 1987-06-30 | Bristol-Myers Company | Antipsychotic fused-ring pyridinylpiperazine derivatives |
| US4766215A (en) * | 1987-02-27 | 1988-08-23 | American Home Products Corporation | Histamine H1 -receptor antagonists |
| SE8701375D0 (sv) * | 1987-04-02 | 1987-04-02 | Leo Ab | Novel pyridyl- and pyrimidyl derivatives |
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| MX173180B (es) * | 1987-10-26 | 1994-02-07 | Pfizer | Procedimiento para preparar agentes ansioliticos |
| US4882432A (en) * | 1989-01-09 | 1989-11-21 | American Home Products Corporation | Polycyclic-carbamic acid piperazinoalkyl esters and amides |
| GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
| EP0395313B1 (en) * | 1989-04-22 | 1999-12-15 | American Home Products Corporation | Tertiary alkyl functionalized piperazine derivatives |
| US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
| US5055470A (en) * | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| US5656762A (en) | 1990-12-28 | 1997-08-12 | Neurogen Corporation | 4-piperidino-and piperazinomethyl-2-phenylimidazole derivatives, dopamine receptor subtype specific ligands |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
| EP0538693A3 (en) * | 1991-10-23 | 1994-08-17 | Squibb & Sons Inc | Stereoselective preparation of halophenyl alcohols |
| IL103499A0 (en) * | 1991-10-24 | 1993-03-15 | Bristol Myers Squibb Co | Pharmaceutical compositions for treating anxiety in benzodiazepine withdrawn patients |
| SE9201239D0 (sv) * | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
| US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| DE4243287A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-Substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
| RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| ES2074946B1 (es) * | 1993-07-19 | 1996-06-16 | Ferrer Int | Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida. |
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| CA2187542C (en) * | 1994-04-18 | 2000-02-01 | Nobuyuki Takahashi | Adamantane derivative, process for producing the same, and use thereof |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
| JP5387917B2 (ja) | 2007-05-14 | 2014-01-15 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 新規なカルバモイルオキシアリールアルカノイルアリールピペラジン化合物、該化合物を含む薬剤組成物及び該化合物の投与による疼痛、不安神経症及びうつ病を治療する方法 |
| HK1215170A1 (zh) | 2012-11-14 | 2016-08-19 | The Johns Hopkins University | 治療精神分裂症的方法和組合物 |
| WO2021236879A1 (en) | 2020-05-20 | 2021-11-25 | The Board Of Trustees Of The University Of Illinois | Method for treating lysosomal storage diseases with histatin peptides |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE589092A (esLanguage) * | 1959-03-26 | |||
| US2979508A (en) * | 1959-10-12 | 1961-04-11 | Paul A J Janssen | Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols |
| US2973360A (en) * | 1959-10-12 | 1961-02-28 | Paul A J Janssen | Certain 1-(2-theonyl lower alkyl)-4-(heterocyclic substituted)-piperazines |
| US2985657A (en) * | 1959-10-12 | 1961-05-23 | Paul A J Janssen | 1-(aroylalkyl)-4-heterocyclylpiperazines |
| NL127996C (esLanguage) * | 1963-11-19 | |||
| GB1259685A (en) * | 1969-04-03 | 1972-01-12 | Soc D Etudes Prod Chimique | Amino-pyrimidine derivatives |
| BE758380A (fr) * | 1969-11-04 | 1971-04-16 | Sumitomo Chemical Co | Procede de preparation de derives d'aryl-cetones |
| GB1307256A (en) * | 1970-09-15 | 1973-02-14 | Science Union & Cie | Piperazine derivatives and a process for their preparation |
| BE882836A (fr) * | 1979-05-15 | 1980-08-18 | Soc D Etudes Prod Chimique | Nouveaux derives halogenes de l'isopropylamino pyrimidine, leur preparation et leur utilisaton therapeutique |
| US4316899A (en) * | 1979-08-24 | 1982-02-23 | Beecham Group Limited | Chromanone derivatives, a process for their preparation and compositions containing them |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
-
1984
- 1984-12-18 US US06/683,309 patent/US4605655A/en not_active Expired - Lifetime
-
1985
- 1985-02-27 ZA ZA851486A patent/ZA851486B/xx unknown
- 1985-03-01 FI FI850850A patent/FI84478C/fi not_active IP Right Cessation
- 1985-03-04 ES ES540901A patent/ES8607254A1/es not_active Expired
- 1985-03-04 AU AU39449/85A patent/AU576555B2/en not_active Expired
- 1985-03-05 LU LU85796A patent/LU85796A1/fr unknown
- 1985-03-05 FR FR8503220A patent/FR2560878B1/fr not_active Expired
- 1985-03-05 SE SE8501067A patent/SE462429B/sv not_active IP Right Cessation
- 1985-03-05 AT AT0064985A patent/AT390951B/de not_active IP Right Cessation
- 1985-03-05 GR GR850561A patent/GR850561B/el not_active IP Right Cessation
- 1985-03-05 PT PT80058A patent/PT80058B/pt unknown
- 1985-03-05 CH CH991/85A patent/CH663022A5/de not_active IP Right Cessation
- 1985-03-05 IT IT19773/85A patent/IT1183483B/it active
- 1985-03-05 BE BE0/214607A patent/BE901880A/fr not_active IP Right Cessation
- 1985-03-05 DK DK100685A patent/DK166149C/da not_active IP Right Cessation
- 1985-03-05 IE IE54685A patent/IE58338B1/en not_active IP Right Cessation
- 1985-03-05 GB GB08505662A patent/GB2155925B/en not_active Expired
- 1985-03-05 HU HU85831A patent/HU193949B/hu unknown
- 1985-03-06 DE DE19853507983 patent/DE3507983A1/de not_active Ceased
- 1985-03-06 NL NL8500628A patent/NL8500628A/nl active Search and Examination
- 1985-03-06 CA CA000475878A patent/CA1256871A/en not_active Expired
- 1985-03-06 KR KR1019850001414A patent/KR920005113B1/ko not_active Expired
-
1987
- 1987-10-01 MY MYPI87002690A patent/MY102240A/en unknown
-
1990
- 1990-05-19 SG SG355/90A patent/SG35590G/en unknown
- 1990-10-11 HK HK828/90A patent/HK82890A/xx not_active IP Right Cessation
-
1991
- 1991-03-22 CY CY1545A patent/CY1545A/en unknown
-
1992
- 1992-05-09 KR KR1019920007854A patent/KR920005114B1/ko not_active Expired
- 1992-05-09 KR KR1019920007855A patent/KR920005694B1/ko not_active Expired
- 1992-06-23 MX MX9203177A patent/MX9203177A/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2104509A1 (es) * | 1995-06-13 | 1997-10-01 | Ferrer Int | Nuevos compuestos derivados de 2-(3,4-disustituido-1-piperazinil)-5-fluoropirimidina. |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8607254A1 (es) | Un procedimiento para la preparacion de derivados de n,n-pipericinilo disustituidos. | |
| AU588015B2 (en) | Heterocyclic piperazine derivatives | |
| IE45929L (en) | Tetralines. | |
| ATE126226T1 (de) | Bis-benzo oder benzopyrido-cyclohepta piperiden- piperidyliden, piperazinderivate als paf antagonisten, und zusammensetzungen. | |
| EP0262399A3 (en) | Cyclic enol derivatives, production and use thereof | |
| ATE251141T1 (de) | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien | |
| MX9102407A (es) | 4 arilpiperazinas y 4-arilpiperidinas novedosas. | |
| ES2057754T3 (es) | Un derivado de 1-piridilimidazol asi como su produccion y su uso. | |
| MY106964A (en) | Fused polycyclic compounds, compositions, methods of manufacture, and their use as paf antagonists, antihistamines and/or antiinflammatory agents. | |
| ES8702908A1 (es) | Procedimiento de preparar nuevas diazepinonas condensadas | |
| ES2000368A6 (es) | Un procedimiento para preparar di-t-butilfenoles sustituidos | |
| MY102080A (en) | Pharmacologically active substituted benzamides | |
| ES8705412A1 (es) | Un procedimiento para la preparacion de derivados de furano con actividad antiulcerosa | |
| NZ212231A (en) | Cephalosporin derivatives; intermediates and pharmaceutical compositions | |
| GR850799B (esLanguage) | ||
| ES8609272A1 (es) | Un procedimiento para preparar derivados de hidantoina | |
| ES8800935A1 (es) | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona | |
| DK540585A (da) | 5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser | |
| ES461228A1 (es) | Procedimiento para la preparacion de derivados de tiazolidi-na. | |
| MX9300915A (es) | Nuevas arilcarbonilaminoalquil-dihidro-oxo-piridinas su produccion y su uso. | |
| IL80623A0 (en) | Cephalosporin compounds | |
| ES8205806A1 (es) | Procedimiento para preparar 3b-hidroximetil-4a-hidroxi-8b- alcoxi-2,9-dioxatriciclo(4,3,1,03,7)decanos | |
| NO870423D0 (no) | 5-substituert octahydroindolizin-analgetika-forbindelser og 7-keto-mellomprodukt. | |
| RO84457B (ro) | Procedeu pentru prepararea unor derivati de acid 7-beta-aminooxazolilacetilamino-3-cefem-4-carboxilic | |
| ES2052509T3 (es) | 2-oxo-1-(fosforo sustituido)-azetidinas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051231 |