DK540585A - 5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser - Google Patents
5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser Download PDFInfo
- Publication number
- DK540585A DK540585A DK540585A DK540585A DK540585A DK 540585 A DK540585 A DK 540585A DK 540585 A DK540585 A DK 540585A DK 540585 A DK540585 A DK 540585A DK 540585 A DK540585 A DK 540585A
- Authority
- DK
- Denmark
- Prior art keywords
- phenyl
- compounds
- alkyl
- piperazinoalkylpyrasolin
- intermediates
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843442860 DE3442860A1 (de) | 1984-11-24 | 1984-11-24 | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK540585D0 DK540585D0 (da) | 1985-11-22 |
| DK540585A true DK540585A (da) | 1986-05-25 |
Family
ID=6251032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK540585A DK540585A (da) | 1984-11-24 | 1985-11-22 | 5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4672063A (da) |
| EP (1) | EP0185909B1 (da) |
| JP (1) | JPS61148164A (da) |
| AT (1) | ATE50448T1 (da) |
| AU (1) | AU578395B2 (da) |
| CA (1) | CA1247101A (da) |
| DD (1) | DD239793A5 (da) |
| DE (2) | DE3442860A1 (da) |
| DK (1) | DK540585A (da) |
| ES (3) | ES8700253A1 (da) |
| FI (1) | FI854603A (da) |
| GR (1) | GR852813B (da) |
| HU (1) | HU195211B (da) |
| IL (1) | IL77124A (da) |
| NO (1) | NO164351C (da) |
| NZ (1) | NZ214289A (da) |
| PT (1) | PT81545B (da) |
| ZA (1) | ZA858418B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK93087A (da) * | 1986-02-27 | 1987-08-28 | Duphar Int Res | Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber |
| FR2648135B1 (fr) * | 1989-06-07 | 1991-09-27 | Pf Medicament | Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique |
| FR2676733B1 (fr) * | 1991-05-22 | 1993-10-01 | Fabre Medicament Pierre | Derives de phenyl-1 dihydro-1,4 hydroxy-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique. |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| AU2003236500B9 (en) * | 2002-06-12 | 2009-07-02 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| ES2462240T3 (es) | 2006-02-28 | 2014-05-22 | Dart Neuroscience (Cayman) Ltd | Piperazinas terapéuticas como inhibidores de PDE4 |
| JP2008148592A (ja) * | 2006-12-15 | 2008-07-03 | Sk Sangyo Kk | 防風網 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| IT1052130B (it) * | 1973-10-15 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
| DE3132915A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3132916A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1984
- 1984-11-24 DE DE19843442860 patent/DE3442860A1/de not_active Withdrawn
-
1985
- 1985-11-01 ZA ZA858418A patent/ZA858418B/xx unknown
- 1985-11-14 AT AT85114466T patent/ATE50448T1/de not_active IP Right Cessation
- 1985-11-14 EP EP85114466A patent/EP0185909B1/de not_active Expired - Lifetime
- 1985-11-14 DE DE8585114466T patent/DE3576075D1/de not_active Expired - Fee Related
- 1985-11-20 HU HU854414A patent/HU195211B/hu not_active IP Right Cessation
- 1985-11-21 US US06/800,327 patent/US4672063A/en not_active Expired - Fee Related
- 1985-11-21 FI FI854603A patent/FI854603A/fi not_active Application Discontinuation
- 1985-11-21 GR GR852813A patent/GR852813B/el unknown
- 1985-11-21 DD DD85283095A patent/DD239793A5/de not_active IP Right Cessation
- 1985-11-22 NZ NZ214289A patent/NZ214289A/xx unknown
- 1985-11-22 PT PT81545A patent/PT81545B/pt not_active IP Right Cessation
- 1985-11-22 ES ES549176A patent/ES8700253A1/es not_active Expired
- 1985-11-22 NO NO854677A patent/NO164351C/no unknown
- 1985-11-22 CA CA000496048A patent/CA1247101A/en not_active Expired
- 1985-11-22 IL IL77124A patent/IL77124A/xx unknown
- 1985-11-22 DK DK540585A patent/DK540585A/da not_active Application Discontinuation
- 1985-11-22 AU AU50350/85A patent/AU578395B2/en not_active Ceased
- 1985-11-25 JP JP60262725A patent/JPS61148164A/ja active Pending
-
1986
- 1986-05-16 ES ES555007A patent/ES8703870A1/es not_active Expired
- 1986-05-16 ES ES555006A patent/ES8703869A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DD239793A5 (de) | 1986-10-08 |
| PT81545B (pt) | 1988-01-22 |
| AU578395B2 (en) | 1988-10-20 |
| NO164351C (no) | 1990-09-26 |
| FI854603A (fi) | 1986-05-25 |
| JPS61148164A (ja) | 1986-07-05 |
| PT81545A (en) | 1985-12-01 |
| ES8703870A1 (es) | 1987-03-01 |
| EP0185909A1 (de) | 1986-07-02 |
| HUT38927A (en) | 1986-07-28 |
| GR852813B (da) | 1986-03-21 |
| AU5035085A (en) | 1986-07-17 |
| CA1247101A (en) | 1988-12-20 |
| ES555007A0 (es) | 1987-03-01 |
| NO854677L (no) | 1986-05-26 |
| DK540585D0 (da) | 1985-11-22 |
| ATE50448T1 (de) | 1990-03-15 |
| ES549176A0 (es) | 1986-10-01 |
| IL77124A0 (en) | 1986-04-29 |
| FI854603A0 (fi) | 1985-11-21 |
| HU195211B (en) | 1988-04-28 |
| US4672063A (en) | 1987-06-09 |
| EP0185909B1 (de) | 1990-02-21 |
| DE3576075D1 (de) | 1990-03-29 |
| ES8700253A1 (es) | 1986-10-01 |
| NZ214289A (en) | 1988-10-28 |
| ES555006A0 (es) | 1987-03-01 |
| NO164351B (no) | 1990-06-18 |
| IL77124A (en) | 1990-03-19 |
| ES8703869A1 (es) | 1987-03-01 |
| ZA858418B (en) | 1986-07-30 |
| DE3442860A1 (de) | 1986-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |