ES8603866A1 - Procedimiento para la preparacion de nuevos compuestos fluo-roalcoxilicos - Google Patents

Procedimiento para la preparacion de nuevos compuestos fluo-roalcoxilicos

Info

Publication number
ES8603866A1
ES8603866A1 ES545145A ES545145A ES8603866A1 ES 8603866 A1 ES8603866 A1 ES 8603866A1 ES 545145 A ES545145 A ES 545145A ES 545145 A ES545145 A ES 545145A ES 8603866 A1 ES8603866 A1 ES 8603866A1
Authority
ES
Spain
Prior art keywords
alkyl
fluoroalkoxysubstituted
pyridylmethylthio
benzimidazoles
sulfinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545145A
Other languages
English (en)
Other versions
ES545145A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of ES545145A0 publication Critical patent/ES545145A0/es
Publication of ES8603866A1 publication Critical patent/ES8603866A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS COMPUESTOS FLUOROALCOXILICOS. CONSISTE EN OXIDAR 2-BENCIMIDAZOLIL-2-PIRIDILMETIL-SULFUROS DE FORMULA (II) PARA OBTENER NUEVOS COMPUESTOS FLUOROALCOXILICOS DE FORMULA (I) DONDE R1 REPRESENTA UN RADICAL ALQUILO C 1 A 3 SUSTITUIDO TOTAL O PREDOMINANTEMENTE CON FLUORO, O UN RADICAL ALQUILO C 1 A 3 O UN RADICAL ALCOXI C 1 A 3, SUSTITUIDO TOTAL O PREDOMINANTEMENTE CON FLUORO; R2 ES H O UN RADICAL ALQUILO C 1 A 3; R3 ES H, UN RADICAL ALQUILO C 1 A 3 O UN RADICAL ALCOXI C 1 A 3; R4 ES H O UN RADICAL ALQUILO C 1 A 3; Y N ES UNO (1). TIENEN APLICACIONES FARMACOLOGICAS.
ES545145A 1983-05-03 1985-07-12 Procedimiento para la preparacion de nuevos compuestos fluo-roalcoxilicos Expired ES8603866A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH240183 1983-05-03

Publications (2)

Publication Number Publication Date
ES545145A0 ES545145A0 (es) 1986-01-16
ES8603866A1 true ES8603866A1 (es) 1986-01-16

Family

ID=4232920

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532149A Expired ES8604927A1 (es) 1983-05-03 1984-05-03 Procedimiento para la preparacion de nuevos compuestos fluoroalcoxilicos
ES545145A Expired ES8603866A1 (es) 1983-05-03 1985-07-12 Procedimiento para la preparacion de nuevos compuestos fluo-roalcoxilicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES532149A Expired ES8604927A1 (es) 1983-05-03 1984-05-03 Procedimiento para la preparacion de nuevos compuestos fluoroalcoxilicos

Country Status (17)

Country Link
US (1) US4555518A (es)
EP (1) EP0134400B1 (es)
JP (2) JPS59206379A (es)
KR (1) KR840009098A (es)
AT (1) ATE87311T1 (es)
AU (1) AU579316B2 (es)
DE (1) DE3486109D1 (es)
DK (1) DK217184A (es)
ES (2) ES8604927A1 (es)
FI (1) FI841759A (es)
GR (1) GR79849B (es)
HU (1) HU195220B (es)
IL (1) IL71664A (es)
NO (1) NO841754L (es)
NZ (1) NZ208023A (es)
PT (1) PT78518B (es)
ZA (1) ZA843288B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
DE3430513A1 (de) * 1984-08-18 1986-02-27 Wella Ag, 6100 Darmstadt Haarfaerbemittel mit diamino-tetrafluorethoxybenzolen sowie neue diamino-tetrafluorethoxybenzole
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
JPS6261978A (ja) * 1985-09-12 1987-03-18 Otsuka Pharmaceut Co Ltd ５−フルオロ−１ｈ−ベンズイミダゾ−ル誘導体
DE3621215A1 (de) * 1986-06-25 1988-01-07 Bayer Ag Fluorhaltige o-phenylendiamine und o-aminophenole
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler
EP0415990A1 (de) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Neue fluoralkoxyverbindungen
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
AT391693B (de) * 1988-11-15 1990-11-12 Cl Pharma Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
SE8804628D0 (sv) 1988-12-22 1988-12-22 Ab Haessle New compounds
US5049674A (en) 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SI0731801T1 (en) 1993-12-01 2002-06-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted aminoalkylaminopyridines
DE69631981T2 (de) * 1995-09-21 2005-04-14 Pharma Pass Ii Llc, Irvine Lansoprazolhaltige Arzneizusammensetzung und Herstellungsverfahren
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
ES2171116B1 (es) * 2000-04-14 2003-08-01 Esteve Quimica Sa Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol.
AU2001296908A1 (en) * 2000-09-29 2002-04-08 Geneva Pharmaceuticals, Inc. Proton pump inhibitor formulation
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
JP2006514108A (ja) * 2002-12-19 2006-04-27 テバ ファーマシューティカル インダストリーズ リミティド パントプラゾールナトリウムの固体状態、それらの調製方法、及び公知のパントプラゾールナトリウム水和物の調製方法
RU2345075C2 (ru) * 2003-01-15 2009-01-27 Сипла Лимитед Способ получения фармацевтических средств и соединения, полученные данным способом
ES2245277T1 (es) * 2003-03-12 2006-01-01 Teva Pharmaceutical Industries Limited Solidos cristalinos y amorfos de pantoprazol y procedimientos para su preparacion.
US7683177B2 (en) * 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045564A (en) * 1974-02-18 1977-08-30 Ab Hassle Benzimidazole derivatives useful as gastric acid secretion inhibitors
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
LU77115A1 (es) * 1977-04-12 1979-01-18
LU77125A1 (es) * 1977-04-12 1979-01-18
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
FR2428035A1 (fr) * 1978-06-05 1980-01-04 Sankyo Co Derives de benzothiazocine et de benzothiazonine, et leur application therapeutique
CH642359A5 (en) * 1978-10-02 1984-04-13 Ciba Geigy Ag Benzimidazole derivatives
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
ZA825106B (en) * 1981-08-13 1983-04-27 Haessle Ab Novel pharmaceutical compositions
IE57646B1 (en) * 1983-12-16 1993-02-10 Wyeth John & Brother Ltd Derivatives of imidazoquinolines and analogues thereof
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
FR2597478B1 (fr) * 1986-04-21 1988-12-16 Esteve Labor Dr Benzimidazoles et imidazopyridines sulfonamides, leur preparation et leur application en tant que medicaments.
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
JPH0643426B2 (ja) * 1986-07-25 1994-06-08 東京田辺製薬株式会社 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤

Also Published As

Publication number Publication date
ATE87311T1 (de) 1993-04-15
EP0134400A2 (de) 1985-03-20
JPS59206379A (ja) 1984-11-22
IL71664A (en) 1987-11-30
IL71664A0 (en) 1984-07-31
JPH0587508B2 (es) 1993-12-16
DK217184A (da) 1984-11-04
ES8604927A1 (es) 1986-03-01
PT78518B (de) 1986-07-14
ES545145A0 (es) 1986-01-16
JPH0572391B2 (es) 1993-10-12
NZ208023A (en) 1987-07-31
EP0134400A3 (en) 1985-12-11
US4555518A (en) 1985-11-26
ZA843288B (en) 1984-12-24
NO841754L (no) 1984-11-05
DE3486109D1 (de) 1993-04-29
ES532149A0 (es) 1986-03-01
PT78518A (de) 1984-06-01
FI841759A (fi) 1984-11-04
GR79849B (es) 1984-10-31
AU2750084A (en) 1984-11-08
EP0134400B1 (de) 1993-03-24
AU579316B2 (en) 1988-11-24
JPH0586037A (ja) 1993-04-06
KR840009098A (ko) 1984-12-24
FI841759A0 (fi) 1984-05-03
HU195220B (en) 1988-04-28
DK217184D0 (da) 1984-05-01

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