ES8601943A1 - Procedimiento para preparar derivados de benzotiazina - Google Patents

Procedimiento para preparar derivados de benzotiazina

Info

Publication number
ES8601943A1
ES8601943A1 ES539025A ES539025A ES8601943A1 ES 8601943 A1 ES8601943 A1 ES 8601943A1 ES 539025 A ES539025 A ES 539025A ES 539025 A ES539025 A ES 539025A ES 8601943 A1 ES8601943 A1 ES 8601943A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
substd
opt
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539025A
Other languages
English (en)
Other versions
ES539025A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8601943A1 publication Critical patent/ES8601943A1/es
Publication of ES539025A0 publication Critical patent/ES539025A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE BENZOTIAZINA. CONSISTE EN: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNO DE LOS COMPUESTOS DE LAS FORMULAS (III), EN CONDICIONES DE UNA SUSTITUCION NUCLEOFILICA, EN UN DISOLVENTE ORGANICO POLAR, CON O SIN PRESENCIA DE UNA BASE AUXILIAR PARA CAPTAR EL ACIDO QUE SE FORMA, Y A UNA TEMPERATURA ENTRE 0 Y 160C, PARA OBTENER DERIVADOS DE BENZOTIAZINA DE FORMULA (I), DONDE R(1), R(1) Y R(1), SON IGUALES O DIFERENTES E, INDEPENDIENTEMENTE ENTRE SI, SIGNIFICAN H, ACETAMIDO O AMIDO, ALQUILO C 1 A 4 Y OTROS; R(2) SIGNIFICA H, ALQUILO DE C 1 A 10 DE CADENA LINEAL O RAMIFICADO, ALQUENILO DE C 3 A 10 Y OTROS; R(3) SIGNIFICA H, ALQUILO DE C 1 A 10 DE CADENA LINEAL O RAMIFICADO, ALQUENILO C 3 A 10 Y OTROS; R(4) Y R(4) SON IGUALES O DISTINTOS Y SIGNIFICAN H, ALCOXI C 1 A 3, HALOGENO Y OTROS; R(5) ES H O ALQUILO C 1 A 3; Y R(6) ES UNA ESTRUCTURA PARCIAL DEL GRUPO DE FORMULAS (IV).
ES539025A 1983-12-27 1984-12-24 Procedimiento para preparar derivados de benzotiazina Granted ES539025A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833347173 DE3347173A1 (de) 1983-12-27 1983-12-27 Neue benzothiazin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung

Publications (2)

Publication Number Publication Date
ES8601943A1 true ES8601943A1 (es) 1985-11-16
ES539025A0 ES539025A0 (es) 1985-11-16

Family

ID=6218218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539025A Granted ES539025A0 (es) 1983-12-27 1984-12-24 Procedimiento para preparar derivados de benzotiazina

Country Status (20)

Country Link
US (1) US4595685A (es)
EP (1) EP0146893B1 (es)
JP (1) JPS60156679A (es)
KR (1) KR920000762B1 (es)
AT (1) ATE36710T1 (es)
AU (1) AU574122B2 (es)
CA (1) CA1251791A (es)
DE (2) DE3347173A1 (es)
DK (1) DK627584A (es)
ES (1) ES539025A0 (es)
FI (1) FI79844C (es)
GR (1) GR82584B (es)
HU (1) HU191729B (es)
IE (1) IE58210B1 (es)
IL (1) IL73926A (es)
NO (1) NO163011C (es)
NZ (1) NZ210685A (es)
PH (1) PH21730A (es)
PT (1) PT79751B (es)
ZA (1) ZA8410026B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584300A (en) * 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
JPH0625186B2 (ja) * 1985-03-19 1994-04-06 参天製薬株式会社 ２−アリ−ルベンゾチアジン誘導体
EP0237573B1 (en) * 1985-07-29 1992-01-15 Santen Pharmaceutical Co., Ltd. Novel benzothiazine derivatives
DE3529994A1 (de) * 1985-08-22 1987-02-26 Hoechst Ag Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE3614355A1 (de) * 1986-04-28 1987-10-29 Hoechst Ag Neue benzothiazinon-derivate, verfahren zu ihrer herstellung , sie enthaltende arzneimittel und deren verwendung
DE3614363A1 (de) * 1986-04-28 1987-10-29 Hoechst Ag Benzothiazinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
JPS6357578A (ja) * 1986-08-27 1988-03-12 Santen Pharmaceut Co Ltd ベンゾチアジン誘導体
DE3724366A1 (de) * 1987-07-23 1989-02-02 Hoechst Ag Benzothiazinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE3726759A1 (de) * 1987-08-12 1989-03-09 Hoechst Ag Benzothiazinon-oxide, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung sowie zwischenprodukte zu ihrer herstellung
WO1990015607A1 (fr) * 1989-06-16 1990-12-27 Santen Pharmaceutical Co., Ltd. Medicament pour l'ameliorations des fonctions cerebrales

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1438225A (fr) * 1964-09-24 1966-05-13 Centre Nat Rech Scient Dérivés de la benzothiazine et leur préparation
GB1270970A (en) * 1968-11-18 1972-04-19 Merck Patent Gmbh 3-aryl-benzazines and process for their preparation
US3622572A (en) * 1969-04-01 1971-11-23 Squibb & Sons Inc Process for producing morpholinoalkyl benzothiazinones and related compounds
US3715353A (en) * 1970-10-12 1973-02-06 Squibb & Sons Inc (aminoalkoxy-benzylidene)-2h-benzothiazine-3(4h)-ones and related compounds
US3733321A (en) * 1971-07-06 1973-05-15 Squibb & Sons Inc 1,4-benzothiazin-3-ones
DE2912445A1 (de) * 1979-03-29 1980-10-09 Thiemann Chem Pharm Fab 2-methylen-2,3-dihydro-3-oxo-4h-1,4- benzothiazin-1,1-dioxid-verbindungen, ihre herstellung und verwendung
US4584300A (en) * 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor

Also Published As

Publication number Publication date
HU191729B (en) 1987-04-28
FI79844C (fi) 1990-03-12
ZA8410026B (en) 1985-10-30
EP0146893A2 (de) 1985-07-03
IL73926A0 (en) 1985-03-31
KR920000762B1 (ko) 1992-01-21
PH21730A (en) 1988-02-10
JPH0572383B2 (es) 1993-10-12
ES539025A0 (es) 1985-11-16
AU574122B2 (en) 1988-06-30
DK627584A (da) 1985-06-28
IL73926A (en) 1989-05-15
EP0146893A3 (en) 1985-07-31
JPS60156679A (ja) 1985-08-16
FI845071L (fi) 1985-06-28
EP0146893B1 (de) 1988-08-24
DK627584D0 (da) 1984-12-21
NO163011C (no) 1990-03-21
CA1251791A (en) 1989-03-28
US4595685A (en) 1986-06-17
IE843321L (en) 1985-06-27
DE3473597D1 (en) 1988-09-29
KR850004490A (ko) 1985-07-15
NO163011B (no) 1989-12-11
NO845217L (no) 1985-06-28
GR82584B (en) 1985-04-23
HUT36812A (en) 1985-10-28
FI845071A0 (fi) 1984-12-20
AU3716684A (en) 1985-07-04
PT79751B (de) 1986-11-20
PT79751A (de) 1985-01-01
IE58210B1 (en) 1993-08-11
NZ210685A (en) 1988-02-29
ATE36710T1 (de) 1988-09-15
FI79844B (fi) 1989-11-30
DE3347173A1 (de) 1985-07-04

Similar Documents

Publication Publication Date Title
ES8601943A1 (es) Procedimiento para preparar derivados de benzotiazina
EP0686627A3 (de) Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES8601213A1 (es) Derivados de cefalosporina
AU692539B2 (en) Phenyl-substituted alkenylcarboguanidides carrying perfluoroalkyl groups, a process for their preparation, their use as a medicament or diagnostic agent, and also a medicament containing them
ES8104792A1 (es) Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos
ES8404313A1 (es) Un procedimiento para la preparacion de derivados de etanolamina.
MY101126A (en) Novel compounds
ES8604505A1 (es) Procedimiento para la obtencion de derivados de 1-(4'-alquilsulfonilfenil)-2-amino-1,3-propandiol n-substituidos
GB2129425B (en) 5-halovinyl-2'-deoxyuridine derivatives
IL111539A0 (en) Pyrazole derivatives, their preparation and pharmaceutical compositions containing them
EP0103552A3 (en) Novel derivatives of guanine ii
ES8604591A1 (es) Procedimiento para preparar nuevas 11-piperazinil-5h-imidazo(2,1-c)(1,4)-benzodiazepinas
FR2258840A1 (en) (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
DE3687703D1 (de) Cephalosporinderivate und sie enthaltende antibiotika.
ES8603175A1 (es) Procedimiento para preparar derivados de benzotiazol
ES8401952A1 (es) Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.
ATE2004T1 (de) Piperazinyl-imidazo(1,2-a)pyrazin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES464729A1 (es) Un procedimiento para la preparacion de benzisotiazolonas amino-alquil sustituidas.
SE8400688D0 (sv) Novel pharmacologically active compounds
FR2228779A1 (en) (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
ES8604099A1 (es) Un procedimiento de preparar un derivado de n-acil-amino- acido
ES8800141A1 (es) Un procedimiento para preparar un derivado de semicarbazida
SE8600742L (sv) Behandlingsmetod
FR2280364A1 (fr) Nouveaux derives de l'acide phenylacetique, leur preparation et les medicaments qui en contiennent

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612