FR2228779A1 - (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use - Google Patents

(4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Info

Publication number
FR2228779A1
FR2228779A1 FR7316634A FR7316634A FR2228779A1 FR 2228779 A1 FR2228779 A1 FR 2228779A1 FR 7316634 A FR7316634 A FR 7316634A FR 7316634 A FR7316634 A FR 7316634A FR 2228779 A1 FR2228779 A1 FR 2228779A1
Authority
FR
France
Prior art keywords
phenylpiperazino
human
halogen
alkyl esters
analgesic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7316634A
Other languages
French (fr)
Other versions
FR2228779B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7316634A priority Critical patent/FR2228779A1/en
Priority to BE143707A priority patent/BE814287A/en
Priority to DE19742421537 priority patent/DE2421537C3/en
Priority to GB1987374A priority patent/GB1437868A/en
Priority to US05/467,595 priority patent/US3953449A/en
Priority to ES426135A priority patent/ES426135A1/en
Priority to NL7406258A priority patent/NL7406258A/xx
Application granted granted Critical
Publication of FR2228779B1 publication Critical patent/FR2228779B1/fr
Publication of FR2228779A1 publication Critical patent/FR2228779A1/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Cpds. of formula: and their acid-addition salts where n is 1,2,3 or 4; R1 is 1-10C alkyl; phenyl opt. subst. by 1-3 halogen, OH, acetoxy, 1-5C alkoxy, NH2, or: where R3 is H, halogen, CF3, -OCF3, -SCF3; the group where R is 1-5C alkyl; where Ar is phenyl, cyclohexyl, piperidiono, and R4 is H, OH; where m is 2 to 6; where R5 is H, halogen or -NH- where R6 is one or two opt. 1-3C alkyl, halogen, CF3, -OCF3, -SCF3; R7NH - where R7 is 1-6C alkyl, phenyl or naphthyl; or where R8 is H or Cl; R2 is H, halogen, 1-3C alkoxy, CF3, -OCF3, -SCF3; does of 50-2000 mg orally and up to 1000 mg parenterally are used.
FR7316634A 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use Granted FR2228779A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR7316634A FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
BE143707A BE814287A (en) 1973-05-09 1974-04-26 ARYL-PIPERAZINO ALCANOLS ESTERS
DE19742421537 DE2421537C3 (en) 1973-05-09 1974-05-03 2- (4-Phenyl-plperazJno) -ethyl-ester, a process for their preparation and pharmaceutical preparations
GB1987374A GB1437868A (en) 1973-05-09 1974-05-06 Arylpiperazinoalkyl esters
US05/467,595 US3953449A (en) 1973-05-09 1974-05-06 2-(4-M-CF3 or -SCF3 phenylpiperazino)-ethyl benzoates
ES426135A ES426135A1 (en) 1973-05-09 1974-05-09 2-(4-M-CF{HD 3 {B or -SCF{HD 3 {B phenylpiperazino)-ethyl benzoates
NL7406258A NL7406258A (en) 1973-05-09 1974-05-09

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7316634A FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Publications (2)

Publication Number Publication Date
FR2228779B1 FR2228779B1 (en) 1975-08-22
FR2228779A1 true FR2228779A1 (en) 1975-08-22

Family

ID=9119011

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7316634A Granted FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Country Status (2)

Country Link
BE (1) BE814287A (en)
FR (1) FR2228779A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
FR2228779B1 (en) 1975-08-22
BE814287A (en) 1974-10-28

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Legal Events

Date Code Title Description
ST Notification of lapse