IL111539A0 - Pyrazole derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Pyrazole derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL111539A0
IL111539A0 IL11153994A IL11153994A IL111539A0 IL 111539 A0 IL111539 A0 IL 111539A0 IL 11153994 A IL11153994 A IL 11153994A IL 11153994 A IL11153994 A IL 11153994A IL 111539 A0 IL111539 A0 IL 111539A0
Authority
IL
Israel
Prior art keywords
lower alkyl
preparation
pharmaceutical compositions
compositions containing
pyrazole derivatives
Prior art date
Application number
IL11153994A
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of IL111539A0 publication Critical patent/IL111539A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Pyrazole derivs. of formula (I) and their acid-addn. salts are new: n = 1-5; A = a gp. of formula (a) or (b): R1 = H or lower alkyl; Q =(CH2)m opt. mono- or disubstd. by lower alkyl α to the O atom; or 2-hydroxypropylene; m = 2-8; p = 4-6; B = linear 1-3C alkylene opt. mono- or disubstd. by lower alkyl α to the O atom; R2 = H, halo,etc.;R3 = H, halo, lower alkyl, lower alkoxy, OH or lower alkanoyloxy; or adjacent R2+R3 = 1-2 alkylenedioxy; R4 = H or lower alkyl; R5 = H, lower alkyl or phenylalkyl; R6 = H, lower alkyl,etc.;R7 = H, lower alkyl,etc.;or adjacent R6+R7 = 1-2C alkylenedioxy; provided that none of R2, R3, R6 and R7 is alkanoyloxy if any of the others is OH and/or A contains OH.
IL11153994A 1993-12-08 1994-11-07 Pyrazole derivatives, their preparation and pharmaceutical compositions containing them IL111539A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4341749A DE4341749A1 (en) 1993-12-08 1993-12-08 3- (Phenylalkylaminoalkyloxy) -5-phenylpyrazole compounds and methods and intermediates for their preparation and medicaments containing these compounds

Publications (1)

Publication Number Publication Date
IL111539A0 true IL111539A0 (en) 1995-01-24

Family

ID=6504420

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11153994A IL111539A0 (en) 1993-12-08 1994-11-07 Pyrazole derivatives, their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP0663395B1 (en)
JP (1) JP3492433B2 (en)
KR (1) KR950017965A (en)
CN (1) CN1109051A (en)
AT (1) ATE201200T1 (en)
AU (1) AU7769494A (en)
CA (1) CA2137446A1 (en)
CZ (1) CZ303194A3 (en)
DE (2) DE4341749A1 (en)
ES (1) ES2156135T3 (en)
FI (1) FI945750A (en)
HU (1) HUT68518A (en)
IL (1) IL111539A0 (en)
NO (1) NO944722L (en)
NZ (1) NZ264883A (en)
PL (1) PL306155A1 (en)
RU (1) RU94045839A (en)
SK (1) SK150694A3 (en)
ZA (1) ZA949537B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422708D0 (en) * 1994-11-10 1995-01-04 Zeneca Ltd Herbicides
FR2773153A1 (en) * 1997-12-29 1999-07-02 Rhone Poulenc Agrochimie NEW FUNGICIDE COMPOUNDS
EP1829873A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists
EP1829866A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1001161A (en) * 1972-05-05 1976-12-07 Burton K. Wasson 5-(3-substituted amino-2-hydroxypropoxy)1,3-disubstituted pyrazoles and method of preparation
DE2828529A1 (en) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh NEW 5-PHENYLPYRAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS
FR2479219A1 (en) * 1980-04-01 1981-10-02 Nativelle Sa Ets AMINO-ALCOXY PYRAZOLES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING SAME
FR2513996A1 (en) * 1981-10-02 1983-04-08 Nativelle Sa Ets PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION
DE3424586A1 (en) * 1984-07-04 1986-01-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-AMINOCARBONYLMETHOXY-5-PHENYL-PYRAZOLE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE4040632A1 (en) * 1990-12-19 1992-06-25 Kali Chemie Pharma Gmbh PHENYL ALKYLAMINOALKYL COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF AND THE COMPOUND CONTAINING THE SAME COMPOUNDS

Also Published As

Publication number Publication date
FI945750A (en) 1995-06-09
HU9403458D0 (en) 1995-02-28
AU7769494A (en) 1995-06-15
CA2137446A1 (en) 1995-06-09
JPH07196622A (en) 1995-08-01
EP0663395B1 (en) 2001-05-16
SK150694A3 (en) 1995-07-11
DE59409756D1 (en) 2001-06-21
ATE201200T1 (en) 2001-06-15
PL306155A1 (en) 1995-06-12
CN1109051A (en) 1995-09-27
KR950017965A (en) 1995-07-22
RU94045839A (en) 1996-09-27
DE4341749A1 (en) 1995-06-14
EP0663395A1 (en) 1995-07-19
JP3492433B2 (en) 2004-02-03
NO944722L (en) 1995-06-09
FI945750A0 (en) 1994-12-07
CZ303194A3 (en) 1995-08-16
NZ264883A (en) 1995-12-21
NO944722D0 (en) 1994-12-07
ZA949537B (en) 1995-08-11
HUT68518A (en) 1995-06-28
ES2156135T3 (en) 2001-06-16

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