ES8505412A1 - Un metodo para producir eficazmente un factor de crecimiento similar a insulina humana - Google Patents
Un metodo para producir eficazmente un factor de crecimiento similar a insulina humanaInfo
- Publication number
- ES8505412A1 ES8505412A1 ES531855A ES531855A ES8505412A1 ES 8505412 A1 ES8505412 A1 ES 8505412A1 ES 531855 A ES531855 A ES 531855A ES 531855 A ES531855 A ES 531855A ES 8505412 A1 ES8505412 A1 ES 8505412A1
- Authority
- ES
- Spain
- Prior art keywords
- gene
- transcription
- igf
- growth factors
- dna synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000006820 DNA synthesis Effects 0.000 title 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
- 102000013275 Somatomedins Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 108700005078 Synthetic Genes Proteins 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000005204 segregation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
METODO PARA PRODUCIR EFICAZMENTE UN FACTOR DE CRECIMIENTO SIMILAR A INSULINA HUMANA.COMPRENDE: A) DESARROLLAR CELULAS DEL HOSPEDANTE QUE CONTIENE UNA CONSTRUCCION FUNCIONAL DE ADN QUE TIENE EL GEN QUE CODIFICA AL IGF UNIDO EN UN MARCO DE LECTURA APROPIADO, CON LAS SECUENCIAS DE SEN/ALES DELANTERAS Y DE ELABORACION SEGREGADORAS RECONOCIDAS POR EL HOSPEDANTE, PARA FORMAR UN GEN ESTRUCTURAL AGUAS ABAJO, Y BAJO EL CONTROL REGULADOR DE LA TRANSCRIPCION Y DE UNA REGION DE INICIACION DE LA TRANSCRIPCION, EN UN VECTOR COMPATIBLE CON EL HOSPEDANTE, Y B) AISLAR EL IGF HUMANO SEGREGADO. EL GEN DE IGF ES UN GEN SINTETICO QUE TIENE CODONES UTILIZADOS PREFERIBLEMENTE POR EL HOSPEDA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48795083A | 1983-04-25 | 1983-04-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8505412A1 true ES8505412A1 (es) | 1985-05-16 |
ES531855A0 ES531855A0 (es) | 1985-05-16 |
Family
ID=23937779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES531855A Granted ES531855A0 (es) | 1983-04-25 | 1984-04-24 | Un metodo para producir eficazmente un factor de crecimiento similar a insulina humana |
Country Status (17)
Country | Link |
---|---|
US (1) | US6642029B1 (es) |
EP (2) | EP0123228B1 (es) |
JP (2) | JP2548105B2 (es) |
AT (2) | ATE220101T1 (es) |
AU (1) | AU576757B2 (es) |
DE (2) | DE3486216T2 (es) |
DK (1) | DK204584A (es) |
ES (1) | ES531855A0 (es) |
FI (1) | FI87799C (es) |
HK (1) | HK65594A (es) |
HU (1) | HU204565B (es) |
IE (2) | IE60228B1 (es) |
IL (1) | IL71634A (es) |
NO (1) | NO174302C (es) |
NZ (1) | NZ207842A (es) |
PT (1) | PT78484B (es) |
ZA (1) | ZA842982B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7198919B1 (en) | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
JPS60501989A (ja) * | 1983-08-10 | 1985-11-21 | アムジエン | インシュリン様成長因子の微生物発現 |
US4758512A (en) * | 1984-03-06 | 1988-07-19 | President And Fellows Of Harvard College | Hosts and methods for producing recombinant products in high yields |
DK108685A (da) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | Vaekstfaktor i |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
JP2549504B2 (ja) * | 1984-12-21 | 1996-10-30 | ア−ス製薬株式会社 | Dna塩基配列、ポリペプチド分泌発現ベクター及び形質転換微生物 |
US5242811A (en) * | 1985-03-26 | 1993-09-07 | Biogen, Inc. | Production of human somatomedin C |
GB8507833D0 (en) * | 1985-03-26 | 1985-05-01 | Biogen Nv | Production of human somatomedin c |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US5342921A (en) * | 1985-03-28 | 1994-08-30 | Chiron Corporation | Superoxide dismutase fusion polypeptides for expression of mammalian proteins |
EP0196056B1 (en) * | 1985-03-28 | 1991-05-22 | Chiron Corporation | Improved expression using fused genes providing for protein product |
US4783524A (en) * | 1985-09-17 | 1988-11-08 | Monsanto Company | Growth factors |
ES2029785T3 (es) * | 1985-10-21 | 1992-10-01 | Fujisawa Pharmaceutical Co., Ltd. | Procedimiento para producir factor de crecimiento tipo insulina i y plasmido para su produccion. |
GB8529014D0 (en) * | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
EP0234862A3 (en) * | 1986-02-28 | 1988-10-05 | Merck & Co. Inc. | Expression of recombinant proteins in yeast |
EP0234871A3 (en) * | 1986-02-28 | 1988-10-12 | Merck & Co. Inc. | Regulatable expression of recombinant proteins in yeast |
JPH0616716B2 (ja) * | 1986-10-14 | 1994-03-09 | 塩野義製薬株式会社 | 酵母におけるヒトpstiの製造法 |
DE3726655A1 (de) * | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
GB8723660D0 (en) * | 1987-10-08 | 1987-11-11 | British Bio Technology | Synthetic gene |
CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
ATE86496T1 (de) * | 1988-02-05 | 1993-03-15 | Ciba Geigy Ag | Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten. |
US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
GB8819826D0 (en) * | 1988-08-20 | 1988-09-21 | Kabivitrum Ab | Glycosylated igf-1 |
GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
NZ236618A (en) * | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
EP0548267A4 (en) * | 1990-09-04 | 1994-11-23 | Salk Inst Biotech Ind | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
CA2105064A1 (en) * | 1991-04-01 | 1992-10-02 | Martin Anthony Gleeson | Genes which influence pichia proteolytic activity, and uses therefor |
TW267102B (es) | 1992-03-13 | 1996-01-01 | Ciba Geigy | |
SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
SE9402370D0 (sv) | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
EP0779927A1 (en) * | 1994-09-08 | 1997-06-25 | Chiron Corporation | A method of improved production of insulin-like growth factor |
US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
ES2293137T3 (es) | 1995-10-11 | 2008-03-16 | Novartis Vaccines And Diagnostics, Inc. | Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas. |
US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Hivポリペプチドの改善された発現およびウイルス様粒子の生成 |
IL145597A0 (en) | 1999-04-08 | 2002-06-30 | Genentech Inc | Composition based on oppositely-charged polypeptides |
WO2003093417A2 (en) | 2002-05-01 | 2003-11-13 | Cell Genesys, Inc. | Lentiviral vector particles resistant to complement inactivation |
EP1667521B1 (en) | 2003-09-12 | 2011-12-07 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency |
EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
MX2009001691A (es) | 2006-08-31 | 2009-02-25 | Hoffmann La Roche | Metodo para produccion del factor de crecimiento i tipo insulina. |
CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
CN103396488A (zh) | 2008-12-12 | 2013-11-20 | 贝林格尔.英格海姆国际有限公司 | 抗igf抗体 |
EP2454368A4 (en) | 2009-07-17 | 2013-01-09 | Aaron Thomas Tabor | COMPOSITIONS AND METHOD FOR THE GENETIC MODIFICATION OF COSMETIC FUNCTION CELLS FOR IMPROVING THE COSMETIC APPEARANCE PICTURE |
US20110152188A1 (en) | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
US20210008172A1 (en) | 2019-07-11 | 2021-01-14 | Opko Biologics Ltd. | Long-acting igf-1 or igf-1 variants and methods of producing same |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
US4443539A (en) | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
CA1200773A (en) * | 1980-02-29 | 1986-02-18 | William J. Rutter | Expression linkers |
AU545912B2 (en) * | 1980-03-10 | 1985-08-08 | Cetus Corporation | Cloned heterologous jive products in bacillies |
US4350764A (en) * | 1980-03-10 | 1982-09-21 | The Regents Of The University Of California | Microbiological synthesis of beta endorphin |
US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
DE3382547D1 (de) * | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
SE8300693L (sv) * | 1983-02-09 | 1984-08-10 | Sven Lofdahl | Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta |
GB8308483D0 (en) * | 1983-03-28 | 1983-05-05 | Health Lab Service Board | Secretion of gene products |
WO1984004330A1 (en) * | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
AU2722184A (en) * | 1983-04-25 | 1984-11-01 | Genentech Inc. | Use of alpha sequences in yeast expression systems |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
US4745179A (en) * | 1984-04-02 | 1988-05-17 | Fujisawa Pharmaceutical Co., Ltd. | 59 Valine insulin-like growth factor I and process for production thereof |
CA1341482C (en) * | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
EP0193112A3 (en) | 1985-02-22 | 1987-02-25 | The Trustees Of Columbia University In The City Of New York | Cdna encoding mammalian insulin-like growth factor ii |
US5084384A (en) * | 1987-04-23 | 1992-01-28 | Monsanto Company | Secretion of insulin-like growth factor-I |
CA1340772C (en) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
GB8927008D0 (en) * | 1989-11-29 | 1990-01-17 | Ciba Geigy | Novel process for the production of unfused protein in e.coli |
EP0548267A4 (en) * | 1990-09-04 | 1994-11-23 | Salk Inst Biotech Ind | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
ATE253120T1 (de) | 1996-12-13 | 2003-11-15 | Chiron Corp | Verfahren zur expression von heterologen proteinen in hefe |
-
1984
- 1984-04-13 EP EP84104175A patent/EP0123228B1/en not_active Expired - Lifetime
- 1984-04-13 AT AT93101654T patent/ATE220101T1/de not_active IP Right Cessation
- 1984-04-13 NZ NZ207842A patent/NZ207842A/en unknown
- 1984-04-13 EP EP93101654A patent/EP0561137B1/en not_active Expired - Lifetime
- 1984-04-13 DE DE84104175T patent/DE3486216T2/de not_active Expired - Fee Related
- 1984-04-13 AT AT84104175T patent/ATE95236T1/de not_active IP Right Cessation
- 1984-04-13 DE DE3486491T patent/DE3486491T2/de not_active Expired - Lifetime
- 1984-04-16 FI FI841524A patent/FI87799C/fi not_active IP Right Cessation
- 1984-04-19 IE IE97584A patent/IE60228B1/en not_active IP Right Cessation
- 1984-04-19 ZA ZA842982A patent/ZA842982B/xx unknown
- 1984-04-19 IE IE940140A patent/IE940140L/xx unknown
- 1984-04-24 DK DK204584A patent/DK204584A/da not_active Application Discontinuation
- 1984-04-24 NO NO841613A patent/NO174302C/no unknown
- 1984-04-24 HU HU841572A patent/HU204565B/hu not_active IP Right Cessation
- 1984-04-24 PT PT78484A patent/PT78484B/pt not_active IP Right Cessation
- 1984-04-24 ES ES531855A patent/ES531855A0/es active Granted
- 1984-04-24 AU AU27233/84A patent/AU576757B2/en not_active Expired
- 1984-04-25 IL IL71634A patent/IL71634A/xx not_active IP Right Cessation
- 1984-04-25 JP JP59082096A patent/JP2548105B2/ja not_active Expired - Lifetime
-
1994
- 1994-06-10 JP JP6128883A patent/JP2530424B2/ja not_active Expired - Lifetime
- 1994-07-07 HK HK65594A patent/HK65594A/xx not_active IP Right Cessation
-
1995
- 1995-05-17 US US08/442,800 patent/US6642029B1/en not_active Expired - Fee Related
Also Published As
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Effective date: 20040916 |