ES8502975A1 - Procedimiento para la preparacion de derivados de benzazepina - Google Patents

Procedimiento para la preparacion de derivados de benzazepina

Info

Publication number
ES8502975A1
ES8502975A1 ES532551A ES532551A ES8502975A1 ES 8502975 A1 ES8502975 A1 ES 8502975A1 ES 532551 A ES532551 A ES 532551A ES 532551 A ES532551 A ES 532551A ES 8502975 A1 ES8502975 A1 ES 8502975A1
Authority
ES
Spain
Prior art keywords
preparation
benzazepine derivatives
general formula
benzazepine
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532551A
Other languages
English (en)
Other versions
ES532551A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8502975A1 publication Critical patent/ES8502975A1/es
Publication of ES532551A0 publication Critical patent/ES532551A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
    • C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D233/16—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZAZEPINA.CONSISTE EN CICLIZAR UN COMPUESTO (II), Y EL COMPUESTO OBTENIDO (I) SE PUEDE TRANSFORMAR EN SU SAL POR ADICION DE UN ACIDO FISIOLOGICAMENTE COMPATIBLE CON ACIDOS ORGANICOS O INORGANICOS. SE LLEVA A CABO A UNAS TEMPERATURAS DE 140-180JC, EN PRESENCIA DE UN DISOLVENTE Y UN AGENTE CONDENSANTE COMO DIETIL CLOROFOSFONATO. E ES UN GRUPO ETILENO, N-PROPILENO. G ES 1-METIL-ETILENO. R1 ES UN GRUPO METILO, HIDROXI O BENCILOXI CON (C1 A C4). R2 ES UN ATOMO DE HIDROGENO, GRUPO METILO, HIDROXI O ALCOXI.LA APLICACION DE ESTOS COMPUESTOS Y EN ESPECIAL DE SUS SALES SON POR SU EFECTO REDUCTOR DE LA FRECUENCIA CARDIACA.
ES532551A 1982-11-16 1984-05-17 Procedimiento para la preparacion de derivados de benzazepina Granted ES532551A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823242345 DE3242345A1 (de) 1982-11-16 1982-11-16 Verfahren zur herstellung von benzazepinderivaten

Publications (2)

Publication Number Publication Date
ES8502975A1 true ES8502975A1 (es) 1985-02-01
ES532551A0 ES532551A0 (es) 1985-02-01

Family

ID=6178258

Family Applications (2)

Application Number Title Priority Date Filing Date
ES527270A Expired ES8502425A1 (es) 1982-11-16 1983-11-15 Procedimiento para la preparacion de derivados de benzazepina
ES532551A Granted ES532551A0 (es) 1982-11-16 1984-05-17 Procedimiento para la preparacion de derivados de benzazepina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES527270A Expired ES8502425A1 (es) 1982-11-16 1983-11-15 Procedimiento para la preparacion de derivados de benzazepina

Country Status (12)

Country Link
KR (1) KR900006325B1 (es)
AT (1) AT389509B (es)
CA (1) CA1207764A (es)
DD (1) DD215541A5 (es)
DE (1) DE3242345A1 (es)
DK (1) DK155666C (es)
ES (2) ES8502425A1 (es)
FI (1) FI77234C (es)
GR (1) GR79427B (es)
HU (1) HU190918B (es)
NO (1) NO168244C (es)
PT (1) PT77676B (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474090A (en) * 1966-12-22 1969-10-21 American Cyanamid Co 3-aminoalkyl-1,3-benzodiazepin-2-ones
US3780023A (en) * 1972-06-30 1973-12-18 J Suh 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
DE2639718A1 (de) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K Neue phenylaethylamine

Also Published As

Publication number Publication date
CA1207764A (en) 1986-07-15
ATA363283A (de) 1989-05-15
NO834176L (no) 1984-05-18
ES527270A0 (es) 1985-01-01
PT77676B (pt) 1986-05-12
ES8502425A1 (es) 1985-01-01
AT389509B (de) 1989-12-27
DK519983A (da) 1984-05-17
KR840006627A (ko) 1984-12-01
DE3242345A1 (de) 1984-05-17
HU190918B (en) 1986-12-28
DK155666B (da) 1989-05-01
DK519983D0 (da) 1983-11-14
ES532551A0 (es) 1985-02-01
FI834121A0 (fi) 1983-11-10
GR79427B (es) 1984-10-22
FI834121A (fi) 1984-05-17
FI77234B (fi) 1988-10-31
DD215541A5 (de) 1984-11-14
NO168244B (no) 1991-10-21
KR900006325B1 (ko) 1990-08-28
FI77234C (fi) 1989-02-10
DK155666C (da) 1989-09-04
PT77676A (de) 1983-12-01
NO168244C (no) 1992-01-29

Similar Documents

Publication Publication Date Title
ZA911153B (en) Process for the preparation of oxetanones
IL99525A0 (en) Fused ring analogs of nitrogen containing nonaromatic heterocycles
KR960034204A (ko) 항-천식 작용을 지닌 피리도[3,2-e]피라지논 및 이의 제조방법
IL110436A (en) Acylated tricyclic benzazepines and similar compounds, their preparation and pharmaceutical vasopressin antagonist compositions containing them
CA2105923A1 (en) 7-isoindolinyl-quinolone derivatives and 7-isoindolinyl-naphthyridone derivatives
CA2080249A1 (en) Preparation of substituted piperidines
CA1273957C (es)
AU617188B2 (en) Azepines
ES8502975A1 (es) Procedimiento para la preparacion de derivados de benzazepina
IE780151L (en) Benzisoquinolines
IE791930L (en) Cyclohexadienes.
ES8502424A1 (es) Procedimiento para la preparacion de derivados de benzazepina
FR2378788A1 (fr) Derives de cephalosporine et leur procede de fabrication
ES8400401A1 (es) "un procedimiento para preparar un 1,4-dialcohilo inferior-3-alcoxicarbonilo inferior-pirrol-2-acetato de alcohilo inferior".
ES484664A1 (es) Un procedimiento para la preparacion de derivados octahidro-1h-benzo 4,5 furo,3,2-e isoquinolina.
ES8505685A1 (es) Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina)
ES8400410A1 (es) Procedimiento para la preparacion de nuevas sulfiminas.
CH611888A5 (en) Process for the preparation of novel acid amides
AU6548190A (en) 1,4-bis(alkylamino)-2,3-diaza-anthracene-9,10-diones
JPS5387353A (en) Preparation of 2-aminomethylindole derivative