ES8502425A1 - Procedimiento para la preparacion de derivados de benzazepina - Google Patents
Procedimiento para la preparacion de derivados de benzazepinaInfo
- Publication number
- ES8502425A1 ES8502425A1 ES527270A ES527270A ES8502425A1 ES 8502425 A1 ES8502425 A1 ES 8502425A1 ES 527270 A ES527270 A ES 527270A ES 527270 A ES527270 A ES 527270A ES 8502425 A1 ES8502425 A1 ES 8502425A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- benzazepine derivatives
- general formula
- benzazepine
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D233/16—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZAZEPINA.CONSISTE EN OXIDAR UNA BENZAZEPINA DE FORMULA (II) CON TETROXIDO DE RUTENIO, EN PRESENCIA DE UN AGENTE OXIDANTE COMO PERYODATO SODICO, EN MEZCLAS DE DISOLVENTES COMO CLOROFORMO/AGUA O CLORURO DE METILENO/AGUA Y A TEMPERATURAS ENTRE 20 Y 50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE ACEPTABLES. DONDE E SIGNIFICA UN GRUPO ETILENO Y OTROS; G SIGNIFICA UN GRUPO ETILENO EVENTUALMENTE SUSTITUIDO CON UN GRUPO ALCOHILO DE C 1 A 3 Y OTROS; R1 Y R2 SIGNIFICAN GRUPOS HIDROXI Y OTROS; R3 Y R4 SIGNIFICAN H O HAL Y OTROS; R5 Y R6 SIGNIFICAN ALCOHILO Y OTROS.SE UTILIZAN EN FARMACIA POR SU EFECTO REDUCTOR DE LA FRECUENCIA CARDIACA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823242345 DE3242345A1 (de) | 1982-11-16 | 1982-11-16 | Verfahren zur herstellung von benzazepinderivaten |
Publications (2)
Publication Number | Publication Date |
---|---|
ES527270A0 ES527270A0 (es) | 1985-01-01 |
ES8502425A1 true ES8502425A1 (es) | 1985-01-01 |
Family
ID=6178258
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527270A Expired ES8502425A1 (es) | 1982-11-16 | 1983-11-15 | Procedimiento para la preparacion de derivados de benzazepina |
ES532551A Granted ES532551A0 (es) | 1982-11-16 | 1984-05-17 | Procedimiento para la preparacion de derivados de benzazepina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532551A Granted ES532551A0 (es) | 1982-11-16 | 1984-05-17 | Procedimiento para la preparacion de derivados de benzazepina |
Country Status (12)
Country | Link |
---|---|
KR (1) | KR900006325B1 (es) |
AT (1) | AT389509B (es) |
CA (1) | CA1207764A (es) |
DD (1) | DD215541A5 (es) |
DE (1) | DE3242345A1 (es) |
DK (1) | DK155666C (es) |
ES (2) | ES8502425A1 (es) |
FI (1) | FI77234C (es) |
GR (1) | GR79427B (es) |
HU (1) | HU190918B (es) |
NO (1) | NO168244C (es) |
PT (1) | PT77676B (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3474090A (en) * | 1966-12-22 | 1969-10-21 | American Cyanamid Co | 3-aminoalkyl-1,3-benzodiazepin-2-ones |
US3780023A (en) * | 1972-06-30 | 1973-12-18 | J Suh | 2-aralkylamino-4,5-dihydro-3h-1,3-benzodiazepines |
US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
DE2639718A1 (de) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | Neue phenylaethylamine |
-
1982
- 1982-11-16 DE DE19823242345 patent/DE3242345A1/de not_active Withdrawn
-
1983
- 1983-10-12 AT AT0363283A patent/AT389509B/de not_active IP Right Cessation
- 1983-11-09 GR GR72933A patent/GR79427B/el unknown
- 1983-11-10 FI FI834121A patent/FI77234C/fi not_active IP Right Cessation
- 1983-11-14 DD DD83256668A patent/DD215541A5/de not_active IP Right Cessation
- 1983-11-14 DK DK519983A patent/DK155666C/da not_active IP Right Cessation
- 1983-11-15 ES ES527270A patent/ES8502425A1/es not_active Expired
- 1983-11-15 HU HU833932A patent/HU190918B/hu unknown
- 1983-11-15 NO NO834176A patent/NO168244C/no not_active IP Right Cessation
- 1983-11-15 PT PT77676A patent/PT77676B/pt unknown
- 1983-11-16 KR KR1019830005432A patent/KR900006325B1/ko not_active IP Right Cessation
- 1983-11-16 CA CA000441311A patent/CA1207764A/en not_active Expired
-
1984
- 1984-05-17 ES ES532551A patent/ES532551A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
KR900006325B1 (ko) | 1990-08-28 |
ATA363283A (de) | 1989-05-15 |
DK519983A (da) | 1984-05-17 |
HU190918B (en) | 1986-12-28 |
PT77676B (pt) | 1986-05-12 |
ES8502975A1 (es) | 1985-02-01 |
CA1207764A (en) | 1986-07-15 |
FI834121A0 (fi) | 1983-11-10 |
DK155666B (da) | 1989-05-01 |
KR840006627A (ko) | 1984-12-01 |
DK519983D0 (da) | 1983-11-14 |
FI77234B (fi) | 1988-10-31 |
DD215541A5 (de) | 1984-11-14 |
PT77676A (de) | 1983-12-01 |
NO834176L (no) | 1984-05-18 |
FI77234C (fi) | 1989-02-10 |
GR79427B (es) | 1984-10-22 |
AT389509B (de) | 1989-12-27 |
ES527270A0 (es) | 1985-01-01 |
DE3242345A1 (de) | 1984-05-17 |
FI834121A (fi) | 1984-05-17 |
NO168244B (no) | 1991-10-21 |
ES532551A0 (es) | 1985-02-01 |
NO168244C (no) | 1992-01-29 |
DK155666C (da) | 1989-09-04 |
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