ES8407495A1 - Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados - Google Patents

Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados

Info

Publication number
ES8407495A1
ES8407495A1 ES528401A ES528401A ES8407495A1 ES 8407495 A1 ES8407495 A1 ES 8407495A1 ES 528401 A ES528401 A ES 528401A ES 528401 A ES528401 A ES 528401A ES 8407495 A1 ES8407495 A1 ES 8407495A1
Authority
ES
Spain
Prior art keywords
preparation
acid addition
addition salts
cephalosporins
crystalline acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528401A
Other languages
English (en)
Other versions
ES528401A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8407495A1 publication Critical patent/ES8407495A1/es
Publication of ES528401A0 publication Critical patent/ES528401A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE SALES DE COMPUESTOS DE CEFEM CRISTALIZADOS, POR ADICION DE ACIDOS Y DE SUS HIDRATOS, DE FORMULA (I), EN LA QUE XC ES UN ANION DE UN ACIDO MONOBASICO, E Y2C ES UN ANION DE UN ACIDO DIBASICO.CONSISTE EN LA REACCION DE UNA CEFEM-BETAINA, DE FORMULA (II), CON UN ACIDO DE FORMULA H2Y, EN LAS QUE X E Y SON LOS MISMOS QUE EN LA FORMULA (I). LOS ACIDOS PUEDEN SER GENERADOS IN SITU POR ADICION DE UN ACIDO FUERTE A LA SAL METALICA CORRESPONDIENTE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES528401A 1982-12-28 1983-12-26 Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados Granted ES528401A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823248281 DE3248281A1 (de) 1982-12-28 1982-12-28 Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8407495A1 true ES8407495A1 (es) 1984-09-16
ES528401A0 ES528401A0 (es) 1984-09-16

Family

ID=6181953

Family Applications (1)

Application Number Title Priority Date Filing Date
ES528401A Granted ES528401A0 (es) 1982-12-28 1983-12-26 Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados

Country Status (28)

Country Link
US (1) US4609653A (es)
EP (1) EP0112550B1 (es)
JP (1) JPH0723382B2 (es)
KR (1) KR910000420B1 (es)
AR (1) AR245133A1 (es)
AT (1) ATE50261T1 (es)
AU (1) AU562714B2 (es)
CA (1) CA1235690A (es)
CS (2) CS241070B2 (es)
DD (1) DD215552A5 (es)
DE (2) DE3248281A1 (es)
DK (1) DK166211C (es)
DZ (1) DZ592A1 (es)
ES (1) ES528401A0 (es)
FI (1) FI76094C (es)
GR (1) GR79444B (es)
HU (1) HU191385B (es)
IE (1) IE56488B1 (es)
IL (1) IL70544A (es)
MA (1) MA19990A1 (es)
NO (1) NO834824L (es)
NZ (1) NZ206704A (es)
OA (1) OA07622A (es)
PH (1) PH19269A (es)
PT (1) PT77896B (es)
SU (1) SU1292668A3 (es)
YU (1) YU43200B (es)
ZA (1) ZA839593B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
EP0150507B1 (en) * 1983-12-29 1992-08-05 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for producing the same and compositions containing them
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
JPH0649707B2 (ja) * 1985-03-01 1994-06-29 第一製薬株式会社 ３−ピリジニウムメチルセフエム誘導体
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE4440141A1 (de) 1994-11-10 1996-05-15 Hoechst Ag Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
EP1382608B1 (en) * 2001-04-23 2005-08-31 Shionogi & Co., Ltd. Sulfate of cephem compound
JPWO2004039816A1 (ja) * 2002-10-29 2006-03-02 塩野義製薬株式会社 セフェム化合物の無機酸塩の結晶
CN101172982B (zh) * 2006-11-03 2011-06-08 河北凯盛医药科技有限公司 一种硫酸头孢匹罗的制备方法
WO2008056221A2 (en) * 2006-11-06 2008-05-15 Orchid Chemicals & Pharmaceuticals Limited Crystalline sulfate salt of cephalosporin antibiotic
CN101104621A (zh) * 2007-05-08 2008-01-16 深圳信立泰药业股份有限公司 制备高纯度硫酸头孢匹罗的工艺
CN101284840B (zh) * 2008-05-29 2012-07-04 管小明 硫酸头孢匹罗的合成方法
CN103044455B (zh) * 2011-10-17 2015-04-01 苏州中联化学制药有限公司 硫酸头孢匹罗混粉的返工方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS523091A (en) * 1975-06-23 1977-01-11 Takeda Chem Ind Ltd A prcess for preparing cephalosporins
IT1145686B (it) * 1979-05-25 1986-11-05 Glaxo Group Ltd Intermedi per la preparazione di antibiotici cefalosporinici e procedimento per prepararli
JPS5657789A (en) * 1979-10-02 1981-05-20 Glaxo Group Ltd Novel cephalosporin antibiotic
ES511101A0 (es) * 1981-04-03 1983-05-01 Fujisawa Pharmaceutical Co "procedimiento para preparar un nuevo compuesto de cefem".
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IL70544A0 (en) 1984-03-30
PT77896B (de) 1986-04-21
IE833045L (en) 1984-06-28
JPH0723382B2 (ja) 1995-03-15
DK166211C (da) 1993-08-16
NO834824L (no) 1984-06-29
MA19990A1 (fr) 1984-07-01
PH19269A (en) 1986-02-21
CS997483A2 (en) 1985-07-16
FI834771A (fi) 1984-06-29
IL70544A (en) 1987-01-30
NZ206704A (en) 1986-04-11
IE56488B1 (en) 1991-08-14
EP0112550A2 (de) 1984-07-04
FI834771A0 (fi) 1983-12-23
AR245133A1 (es) 1993-12-30
EP0112550B1 (de) 1990-02-07
DK166211B (da) 1993-03-22
JPS59130888A (ja) 1984-07-27
AU2289383A (en) 1984-07-05
GR79444B (es) 1984-10-30
US4609653A (en) 1986-09-02
DK600183A (da) 1984-06-29
DE3248281A1 (de) 1984-06-28
FI76094B (fi) 1988-05-31
OA07622A (fr) 1985-03-31
KR840007016A (ko) 1984-12-04
AU562714B2 (en) 1987-06-18
KR910000420B1 (ko) 1991-01-25
SU1292668A3 (ru) 1987-02-23
HUT34211A (en) 1985-02-28
DZ592A1 (fr) 2004-09-13
ATE50261T1 (de) 1990-02-15
PT77896A (de) 1984-01-01
YU43200B (en) 1989-04-30
YU251183A (en) 1986-06-30
FI76094C (fi) 1988-09-09
HU191385B (en) 1987-02-27
EP0112550A3 (en) 1985-09-18
ES528401A0 (es) 1984-09-16
DD215552A5 (de) 1984-11-14
CS241070B2 (en) 1986-03-13
DE3381201D1 (de) 1990-03-15
ZA839593B (en) 1984-08-29
DK600183D0 (da) 1983-12-27
CS415791A3 (en) 1992-07-15
CA1235690A (en) 1988-04-26

Similar Documents

Publication Publication Date Title
ES8407495A1 (es) Procedimiento para preparar sales por adicion de acidos de compuestos de cefem cristalizados
ES8401492A1 (es) Procedimiento para la preparacion de derivados de cefem.
ES8304143A1 (es) "procedimiento para la preparacion de derivados de cefem".
ES468475A1 (es) Procedimiento para la preparacion de derivados de cefem
EG15121A (en) Process for preparing of cephalosporin derivatives
ES8603497A1 (es) Procedimiento para preparar derivados de cefalosporina
ES476109A1 (es) Procedimiento para la preparacion de derivados de cefalospo-rina
HUT49614A (en) Process for producing cefalosporin derivatives and pharmaceutical compositions comprising these compounds
HU903828D0 (en) Process for producing cephem acid additioned salts and pharmaceutical products containing such compounds
ES480762A1 (es) Procedimiento para la preparacion de derivados de cefem.
HUT42492A (en) Process for producing cepheme-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
DE3269780D1 (en) Cephalosporin derivatives and process for their preparation
ES8302721A1 (es) Un procedimiento para la preparacion de derivados de cefa- losporina