ES8401492A1 - Procedimiento para la preparacion de derivados de cefem. - Google Patents
Procedimiento para la preparacion de derivados de cefem.Info
- Publication number
- ES8401492A1 ES8401492A1 ES520226A ES520226A ES8401492A1 ES 8401492 A1 ES8401492 A1 ES 8401492A1 ES 520226 A ES520226 A ES 520226A ES 520226 A ES520226 A ES 520226A ES 8401492 A1 ES8401492 A1 ES 8401492A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- cephalosporin derivatives
- compounds
- bacterial infections
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Rigid Pipes And Flexible Pipes (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CEFEM.SE HACE REACCIONAR EL COMPUESTO (II) CON PIRIDINA O UN DERIVADO DEL MISMO, DESPUES DE LO CUAL, EN CASO DE QUE LOS RADICALES R3 Y R6 SEAN GRUPOS FACILMENTE ELIMINABLES, ESTOS SON EFECTIVAMENTE ELIMINADOS POR TRATAMIENTO CON UN AGENTE PARA HIDROLISIS ACIDA, HIDROGENOLISIS O CON TIOUREA. SE OBTIENEN LOS COMPUESTOS (I) Y/O SUS SALES DE ADICION, FARMACEUTICAMENTE ACEPTABLES. EL INTERCAMBIO NUCLEOFILO DEL SUSTITUYENTE R3 SE EFECTUA EN PRESENCIA DE IONES DE SALES NEUTRAS TALES COMO IONES YODURO O TIOCIANATO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823207840 DE3207840A1 (de) | 1982-03-04 | 1982-03-04 | "cephalosporinderivate und verfahren zu ihrer herstellung" |
Publications (2)
Publication Number | Publication Date |
---|---|
ES520226A0 ES520226A0 (es) | 1983-12-01 |
ES8401492A1 true ES8401492A1 (es) | 1983-12-01 |
Family
ID=6157330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520226A Expired ES8401492A1 (es) | 1982-03-04 | 1983-03-02 | Procedimiento para la preparacion de derivados de cefem. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4647556A (es) |
EP (1) | EP0088320B1 (es) |
JP (1) | JPS58162592A (es) |
KR (1) | KR840004117A (es) |
AT (1) | ATE39696T1 (es) |
AU (1) | AU565927B2 (es) |
CA (1) | CA1219857A (es) |
DE (2) | DE3207840A1 (es) |
DK (1) | DK108183A (es) |
ES (1) | ES8401492A1 (es) |
FI (1) | FI830704L (es) |
GR (1) | GR77915B (es) |
HU (1) | HU190442B (es) |
IL (1) | IL68026A0 (es) |
MA (1) | MA19736A1 (es) |
MT (1) | MTP925B (es) |
NO (1) | NO830729L (es) |
NZ (1) | NZ203436A (es) |
OA (1) | OA07335A (es) |
PT (1) | PT76336B (es) |
ZA (1) | ZA831452B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL66726A0 (en) * | 1981-09-08 | 1982-12-31 | Lilly Co Eli | Improvements in or relating to thieno and furopyridinium-substituted cephalosporin derivatives |
US4690921A (en) * | 1983-10-11 | 1987-09-01 | Yamanouchi Pharmaceutical Co., Ltd. | Cephalosporin compounds and salts thereof |
GB2148289B (en) * | 1983-10-17 | 1987-09-23 | Lilly Co Eli | 3-bicyclicpyridinium-methyl cephalosporins |
JPS6094984A (ja) * | 1983-10-28 | 1985-05-28 | Dai Ichi Seiyaku Co Ltd | セフエム誘導体 |
DE150507T1 (de) * | 1983-12-29 | 1987-02-26 | Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
JPS60142987A (ja) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体 |
EP0148004A3 (en) * | 1983-12-30 | 1986-04-23 | Glaxo Group Limited | Cephalosporin antibiotics |
EP0150609A3 (en) * | 1983-12-30 | 1986-04-23 | Glaxo Group Limited | Cephalosporin antibiotics |
JPS60169486A (ja) * | 1984-02-10 | 1985-09-02 | Yamanouchi Pharmaceut Co Ltd | 7−アミノ−3−置換メチル−3−セフエム−4−カルボン酸およびその低級アルキルシリル誘導体の製造法 |
DE3404906A1 (de) * | 1984-02-11 | 1985-08-14 | Bayer Ag, 5090 Leverkusen | 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung |
JPS60222490A (ja) * | 1984-04-17 | 1985-11-07 | Dai Ichi Seiyaku Co Ltd | セフアロスポリン誘導体およびその塩 |
EP0160546A3 (en) * | 1984-04-26 | 1986-12-17 | Yamanouchi Pharmaceutical Co. Ltd. | Cephalosporin compounds, and their production, and medicaments containing them |
EP0182633A3 (en) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporin derivatives |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
GB8626245D0 (en) * | 1985-11-27 | 1986-12-03 | Ici Pharma | Cephalosporin compounds |
US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
JPS63132893A (ja) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤 |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
ATE341554T1 (de) * | 1996-04-04 | 2006-10-15 | Shionogi & Co | Cephemverbindungen und medikamente die diese verbindungen enthalten |
TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
AU2009310959B2 (en) | 2008-10-31 | 2015-05-07 | Shionogi & Co., Ltd. | Cephalosporin having catechol group |
MX2012011521A (es) | 2010-04-05 | 2013-03-08 | Shionogi & Co | Compuestos cefem que tienen un grupo catecol. |
WO2011136268A1 (ja) | 2010-04-28 | 2011-11-03 | 塩野義製薬株式会社 | 新規なセフェム誘導体 |
MX352760B (es) | 2011-09-09 | 2017-12-07 | Merck Sharp & Dohme Corp Star | Metodos para tratar infecciones intrapulmonares. |
WO2013051597A1 (ja) * | 2011-10-04 | 2013-04-11 | 塩野義製薬株式会社 | カテコール基を有するセフェム誘導体 |
TWI547496B (zh) * | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
US20140275000A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane pharmaceutical compositions |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
MX2020004205A (es) | 2013-03-15 | 2021-11-16 | Merck Sharp & Dohme Llc | Composiciones antibioticas de ceftolozano. |
WO2015035376A2 (en) | 2013-09-09 | 2015-03-12 | Calixa Therapeutics, Inc. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4970990A (es) * | 1973-09-29 | 1974-07-09 | ||
US4298606A (en) * | 1974-12-19 | 1981-11-03 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
JPS5919553B2 (ja) * | 1976-01-01 | 1984-05-07 | 武田薬品工業株式会社 | セフアロスポリン |
US4440766A (en) * | 1976-03-09 | 1984-04-03 | Fujisawa Pharmaceutical Co., Ltd. | 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds |
GB1591439A (en) * | 1976-10-01 | 1981-06-24 | Glaxo Operations Ltd | 7-syn (oxyimino -acylamido) cephalosporins |
AR228726A1 (es) * | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
GB2058791B (en) * | 1978-05-26 | 1982-11-24 | Glaxo Group Ltd | Cephalosporin antibiotics |
US4237168A (en) * | 1979-06-11 | 1980-12-02 | The Dow Chemical Company | N-(4-Chloro-2-methylphenyl)-N-hydroxy methanimidamide and its pesticidal use |
DE3006888A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
JPS56131592A (en) * | 1980-03-18 | 1981-10-15 | Bristol Mayers Kenkyusho Kk | Antimicrobial agent |
ZA813787B (en) * | 1980-06-18 | 1982-07-28 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
FR2485540A1 (fr) * | 1980-06-30 | 1981-12-31 | Sanofi Sa | Nouveaux derives antibiotiques des cephalosporines, leur procede de preparation et les medicaments en contenant |
DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4396619A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin betaines |
US4396620A (en) * | 1981-09-08 | 1983-08-02 | Eli Lilly And Company | Cephalosporin quinolinium betaines |
ZA826538B (en) * | 1981-09-08 | 1984-04-25 | Lilly Co Eli | Thieno and furopyridinium-substituted cephalosporin derivatives |
JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
US4501739A (en) * | 1982-01-19 | 1985-02-26 | Eli Lilly And Company | Thieno and furopyridinium-substituted cephalosporins |
-
1982
- 1982-03-04 DE DE19823207840 patent/DE3207840A1/de not_active Withdrawn
-
1983
- 1983-02-25 JP JP58030679A patent/JPS58162592A/ja active Pending
- 1983-02-26 DE DE8383101915T patent/DE3378827D1/de not_active Expired
- 1983-02-26 AT AT83101915T patent/ATE39696T1/de not_active IP Right Cessation
- 1983-02-26 EP EP83101915A patent/EP0088320B1/de not_active Expired
- 1983-03-02 FI FI830704A patent/FI830704L/fi not_active Application Discontinuation
- 1983-03-02 MT MT925A patent/MTP925B/xx unknown
- 1983-03-02 NZ NZ203436A patent/NZ203436A/xx unknown
- 1983-03-02 GR GR70647A patent/GR77915B/el unknown
- 1983-03-02 ES ES520226A patent/ES8401492A1/es not_active Expired
- 1983-03-02 MA MA19954A patent/MA19736A1/fr unknown
- 1983-03-02 KR KR1019830000834A patent/KR840004117A/ko not_active Application Discontinuation
- 1983-03-03 PT PT76336A patent/PT76336B/pt unknown
- 1983-03-03 CA CA000422765A patent/CA1219857A/en not_active Expired
- 1983-03-03 DK DK108183A patent/DK108183A/da not_active Application Discontinuation
- 1983-03-03 HU HU83735A patent/HU190442B/hu unknown
- 1983-03-03 NO NO830729A patent/NO830729L/no unknown
- 1983-03-03 ZA ZA831452A patent/ZA831452B/xx unknown
- 1983-03-03 US US06/471,649 patent/US4647556A/en not_active Expired - Lifetime
- 1983-03-03 AU AU12039/83A patent/AU565927B2/en not_active Ceased
- 1983-03-03 IL IL8368026A patent/IL68026A0/xx unknown
- 1983-03-04 OA OA57929A patent/OA07335A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL68026A0 (en) | 1983-06-15 |
HU190442B (en) | 1986-09-29 |
NZ203436A (en) | 1986-06-11 |
KR840004117A (ko) | 1984-10-06 |
NO830729L (no) | 1983-09-05 |
ES520226A0 (es) | 1983-12-01 |
ZA831452B (en) | 1983-11-30 |
MTP925B (en) | 1984-02-13 |
EP0088320A3 (en) | 1986-03-19 |
MA19736A1 (fr) | 1983-10-01 |
ATE39696T1 (de) | 1989-01-15 |
DK108183A (da) | 1983-09-05 |
AU565927B2 (en) | 1987-10-01 |
JPS58162592A (ja) | 1983-09-27 |
OA07335A (fr) | 1984-08-31 |
EP0088320A2 (de) | 1983-09-14 |
FI830704A0 (fi) | 1983-03-02 |
PT76336B (de) | 1985-12-13 |
CA1219857A (en) | 1987-03-31 |
EP0088320B1 (de) | 1989-01-04 |
PT76336A (de) | 1983-04-01 |
GR77915B (es) | 1984-09-25 |
DE3378827D1 (en) | 1989-02-09 |
FI830704L (fi) | 1983-09-05 |
DE3207840A1 (de) | 1983-09-15 |
DK108183D0 (da) | 1983-03-03 |
AU1203983A (en) | 1983-09-08 |
US4647556A (en) | 1987-03-03 |
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