MTP925B - Cephalosporin derivatives and a process for their preparation - Google Patents

Cephalosporin derivatives and a process for their preparation

Info

Publication number
MTP925B
MTP925B MT925A MTP925A MTP925B MT P925 B MTP925 B MT P925B MT 925 A MT925 A MT 925A MT P925 A MTP925 A MT P925A MT P925 B MTP925 B MT P925B
Authority
MT
Malta
Prior art keywords
preparation
cephalosporin derivatives
compounds
bacterial infections
formulations
Prior art date
Application number
MT925A
Inventor
Rudolf Lattzell
Reiner Kurstetter
Wilfried Schwab
Walter Dueschheimer
Gerhard Seibert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of MTP925B publication Critical patent/MTP925B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rigid Pipes And Flexible Pipes (AREA)

Abstract

The invention relates to cephem derivatives of the general formula I <IMAGE> and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.
MT925A 1982-03-04 1983-03-02 Cephalosporin derivatives and a process for their preparation MTP925B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823207840 DE3207840A1 (en) 1982-03-04 1982-03-04 "CEPHALOSPORINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF"

Publications (1)

Publication Number Publication Date
MTP925B true MTP925B (en) 1984-02-13

Family

ID=6157330

Family Applications (1)

Application Number Title Priority Date Filing Date
MT925A MTP925B (en) 1982-03-04 1983-03-02 Cephalosporin derivatives and a process for their preparation

Country Status (21)

Country Link
US (1) US4647556A (en)
EP (1) EP0088320B1 (en)
JP (1) JPS58162592A (en)
KR (1) KR840004117A (en)
AT (1) ATE39696T1 (en)
AU (1) AU565927B2 (en)
CA (1) CA1219857A (en)
DE (2) DE3207840A1 (en)
DK (1) DK108183A (en)
ES (1) ES8401492A1 (en)
FI (1) FI830704L (en)
GR (1) GR77915B (en)
HU (1) HU190442B (en)
IL (1) IL68026A0 (en)
MA (1) MA19736A1 (en)
MT (1) MTP925B (en)
NO (1) NO830729L (en)
NZ (1) NZ203436A (en)
OA (1) OA07335A (en)
PT (1) PT76336B (en)
ZA (1) ZA831452B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR76701B (en) * 1981-09-08 1984-08-29 Lilly Co Eli
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
ZA847926B (en) * 1983-10-17 1986-05-28 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
JPS6094984A (en) * 1983-10-28 1985-05-28 Dai Ichi Seiyaku Co Ltd Cephem derivative
DE150507T1 (en) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS.
JPS60142987A (en) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd Cephalosporin derivatives
EP0150609A3 (en) * 1983-12-30 1986-04-23 Glaxo Group Limited Cephalosporin antibiotics
EP0148004A3 (en) * 1983-12-30 1986-04-23 Glaxo Group Limited Cephalosporin antibiotics
JPS60169486A (en) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd Preparation of 7-amino-3-substituted methyl-3-cephem-4- carboxylic acid and lower alkylsilyl derivative thereof
DE3404906A1 (en) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-OXADETHIACEPHALOSPORINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
JPS60222490A (en) * 1984-04-17 1985-11-07 Dai Ichi Seiyaku Co Ltd Cephalosporin derivative and its salt
EP0160546A3 (en) * 1984-04-26 1986-12-17 Yamanouchi Pharmaceutical Co. Ltd. Cephalosporin compounds, and their production, and medicaments containing them
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US5147871A (en) * 1986-07-03 1992-09-15 Hoffmann La-Roche, Inc. Anti-bacterial cephalosporin compounds
JPS63132893A (en) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd New cephalosporin derivatives, their production methods, and antibacterial agents containing them as active ingredients
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US6214818B1 (en) * 1996-04-04 2001-04-10 Shionogi & Co., Ltd. Cephem compounds and pharmaceutical compositions containing the same
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
ES2564836T3 (en) 2008-10-31 2016-03-29 Shionogi & Co., Ltd. Cephalosporins that have a catechol group
WO2011125967A1 (en) 2010-04-05 2011-10-13 塩野義製薬株式会社 Cephem compound having catechol group
WO2011136268A1 (en) 2010-04-28 2011-11-03 塩野義製薬株式会社 Novel cephem derivative
US20130065874A1 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
CN103958527A (en) 2011-10-04 2014-07-30 盐野义制药株式会社 Cephem derivative having catechol group
TWI547496B (en) * 2011-10-04 2016-09-01 葛蘭素集團公司 Antibacterial compounds
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
CA2906151A1 (en) 2013-03-15 2014-09-18 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
ES2800603T3 (en) 2013-09-09 2021-01-04 Merck Sharp & Dohme Treatment of infections with ceftolozane / tazobactam in patients with renal impairment
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4970990A (en) * 1973-09-29 1974-07-09
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
JPS5919553B2 (en) * 1976-01-01 1984-05-07 武田薬品工業株式会社 Cephalosporin
US4440766A (en) * 1976-03-09 1984-04-03 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
ZA807323B (en) * 1978-05-26 1981-02-25 Glaxo Group Ltd Cephalosporin antibiotics
AR229883A1 (en) * 1978-05-26 1983-12-30 Glaxo Group Ltd PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC (6R, 7R) -7 - ((Z) -2- (2-AMINOTIAZOL-4-IL) -2- (2-CARBOXIPROP-2-OXIIMINO) -ACETAMIDO) -3- (1 -PIRIDINOMETIL) -CEF-3-EM-4-CARBOXYLATE
US4237168A (en) * 1979-06-11 1980-12-02 The Dow Chemical Company N-(4-Chloro-2-methylphenyl)-N-hydroxy methanimidamide and its pesticidal use
DE3006888A1 (en) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
JPS56131592A (en) * 1980-03-18 1981-10-15 Bristol Mayers Kenkyusho Kk Antimicrobial agent
ZA813787B (en) * 1980-06-18 1982-07-28 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
FR2485540A1 (en) * 1980-06-30 1981-12-31 Sanofi Sa Cephalosporin(s) active against gram-negative bacteria - are 7- 2-2-amino-4-thiazolyl 2-methoxy-imino acetamido 3 hydroxy-1,2,4-triazinyl-thiomethyl 3-cephem 4-carboxylic acid 1-S-oxide(s)
DE3118732A1 (en) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
ZA826538B (en) * 1981-09-08 1984-04-25 Lilly Co Eli Thieno and furopyridinium-substituted cephalosporin derivatives
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
JPS5859991A (en) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd Novel cephem compound and its preparation
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins

Also Published As

Publication number Publication date
EP0088320B1 (en) 1989-01-04
CA1219857A (en) 1987-03-31
ES520226A0 (en) 1983-12-01
FI830704A7 (en) 1983-09-05
KR840004117A (en) 1984-10-06
NZ203436A (en) 1986-06-11
PT76336B (en) 1985-12-13
AU1203983A (en) 1983-09-08
FI830704A0 (en) 1983-03-02
PT76336A (en) 1983-04-01
ZA831452B (en) 1983-11-30
DE3378827D1 (en) 1989-02-09
DK108183A (en) 1983-09-05
IL68026A0 (en) 1983-06-15
EP0088320A3 (en) 1986-03-19
AU565927B2 (en) 1987-10-01
ATE39696T1 (en) 1989-01-15
EP0088320A2 (en) 1983-09-14
OA07335A (en) 1984-08-31
US4647556A (en) 1987-03-03
GR77915B (en) 1984-09-25
JPS58162592A (en) 1983-09-27
ES8401492A1 (en) 1983-12-01
DK108183D0 (en) 1983-03-03
MA19736A1 (en) 1983-10-01
DE3207840A1 (en) 1983-09-15
NO830729L (en) 1983-09-05
FI830704L (en) 1983-09-05
HU190442B (en) 1986-09-29

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