ES8201168A1 - Procedimiento para la preparacion de derivados de cefalospo-rina - Google Patents

Procedimiento para la preparacion de derivados de cefalospo-rina

Info

Publication number
ES8201168A1
ES8201168A1 ES499485A ES499485A ES8201168A1 ES 8201168 A1 ES8201168 A1 ES 8201168A1 ES 499485 A ES499485 A ES 499485A ES 499485 A ES499485 A ES 499485A ES 8201168 A1 ES8201168 A1 ES 8201168A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compounds
cephalosporin derivatives
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499485A
Other languages
English (en)
Other versions
ES499485A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8201168A1 publication Critical patent/ES8201168A1/es
Publication of ES499485A0 publication Critical patent/ES499485A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE CEFALOSPORINA DE FORMULA (I), EN QUE X ES HIDROGENO, ALCOHILO, CARBOXIMETILO U OTROS, Y A ES HIDROGENO O UN RADICAL ESTER. SE BASA EN LA REACCION DE UNA LACTAMA DE FORMULA (II), SIENDO Z'' IGUAL A Z O UN GRUPO ACILOXI, CON UN ACIDO CARBOXILICO DE FORMULA (III) O UN DERIVADO ACTIVADO DEL MISMO, EN QUE R1 ES HIDROGENO O UN GRUPO PROTECTOR DE AMINO, Y X'' ES IGUAL A X U OTROS, LA REACCION SE EFECTUA A TEMPERATURA DE -50 A 80 C Y EN UN MEDIO ALCALINO. SE USAN COMO AGENTES ANTIBACTERIANOS FRENTE A LOS GERMENES GRAMPOSITIVOS Y GRANNEGATIVOS.
ES499485A 1980-02-23 1981-02-17 Procedimiento para la preparacion de derivados de cefalospo-rina Granted ES499485A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803006888 DE3006888A1 (de) 1980-02-23 1980-02-23 Cephalosporinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8201168A1 true ES8201168A1 (es) 1981-12-01
ES499485A0 ES499485A0 (es) 1981-12-01

Family

ID=6095429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499485A Granted ES499485A0 (es) 1980-02-23 1981-02-17 Procedimiento para la preparacion de derivados de cefalospo-rina

Country Status (17)

Country Link
US (2) US4470983A (es)
EP (1) EP0034760B1 (es)
JP (1) JPS56142289A (es)
AT (1) ATE7699T1 (es)
AU (1) AU555444B2 (es)
CA (1) CA1178271A (es)
DE (2) DE3006888A1 (es)
DK (1) DK77981A (es)
EG (1) EG15121A (es)
ES (1) ES499485A0 (es)
FI (1) FI810511L (es)
HU (1) HU185243B (es)
IE (1) IE50930B1 (es)
IL (1) IL62196A0 (es)
NZ (1) NZ196315A (es)
PH (1) PH17455A (es)
ZA (1) ZA811145B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3177090D1 (en) * 1980-12-31 1989-09-28 Fujisawa Pharmaceutical Co 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof
JPS57131795A (en) * 1980-12-31 1982-08-14 Fujisawa Pharmaceut Co Ltd Novel cephem compound and salt thereof, preparation of the same and preventing agent and remedy for microbism
JPS57131794A (en) * 1980-12-31 1982-08-14 Fujisawa Pharmaceut Co Ltd Novel cephem compound or salt thereof, preparation of the same and preventing agent and remedy for microbism containing the same as active constituent
US4427677A (en) * 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
FR2531711A1 (fr) * 1982-08-13 1984-02-17 Rhone Poulenc Sante Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
JPS6197288A (ja) * 1984-10-19 1986-05-15 Kaken Pharmaceut Co Ltd セフアロスポリン化合物
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
CA2005787A1 (en) * 1988-12-29 1990-06-29 Masao Wada Cephalosporin compounds
US5202315A (en) * 1989-05-11 1993-04-13 Lucky, Ltd. Cephalosporin compounds
ATE123034T1 (de) * 1990-03-24 1995-06-15 Lucky Ltd Cephalosporinzwischenverbindungen, verfahren zu ihrer herstellung sowie zur herstellung ihrer endprodukte.
AU656886B2 (en) * 1990-11-09 1995-02-23 Lucky Limited Novel cephalosporin compounds and processes for preparation thereof
KR0154901B1 (ko) * 1992-12-26 1998-11-16 성재갑 신규 세팔로스포린계 항생제(v)
KR950013578B1 (ko) * 1993-04-10 1995-11-09 주식회사럭키 신규 티아(디아)졸 초산의 반응성 티오포스페이트 유도체 및 그의 제조방법
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
EA201070504A1 (ru) 2007-10-25 2010-12-30 Эйкеоджен, Инк. КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
KR101719556B1 (ko) * 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
KR20180093307A (ko) * 2017-02-13 2018-08-22 주식회사 레고켐 바이오사이언스 4, 5-디아미노 치환 피리미딘 유도체의 제조방법 및 이를 제조하기 위한 신규한 화합물

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GB1522140A (en) * 1974-12-20 1978-08-23 Glaxo Lab Ltd Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them
US4200746A (en) * 1974-12-20 1980-04-29 Glaxo Laboratories, Ltd. Cephalosporins
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2758001A1 (de) * 1977-12-24 1979-07-12 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
FR2422668A1 (fr) * 1978-04-14 1979-11-09 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-azidomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
GB2058791B (en) * 1978-05-26 1982-11-24 Glaxo Group Ltd Cephalosporin antibiotics
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
GB2034692B (en) * 1978-09-08 1982-12-01 Fujisawa Pharmaceutical Co Cephem compounds and processes for preparation thereof
US4217348A (en) * 1978-09-28 1980-08-12 E. R. Squibb & Sons, Inc. Cephalosporins having an oxazolidonyloxamido substituted acyl sidechain
US4283397A (en) * 1979-08-01 1981-08-11 Merck & Co., Inc. 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical compositions containing them
EP0027599B1 (en) * 1979-10-12 1984-10-03 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4252802A (en) * 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
US4367228A (en) * 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
US4427677A (en) * 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
EG15121A (en) 1986-09-30
DE3006888A1 (de) 1981-09-10
DK77981A (da) 1981-08-24
US4470983A (en) 1984-09-11
EP0034760B1 (de) 1984-05-30
ZA811145B (en) 1982-03-31
JPS56142289A (en) 1981-11-06
IE810348L (en) 1981-08-23
NZ196315A (en) 1982-12-07
AU6750881A (en) 1981-09-03
PH17455A (en) 1984-08-29
DE3163802D1 (en) 1984-07-05
FI810511L (fi) 1981-08-24
ES499485A0 (es) 1981-12-01
ATE7699T1 (de) 1984-06-15
IL62196A0 (en) 1981-03-31
EP0034760A1 (de) 1981-09-02
HU185243B (en) 1984-12-28
AU555444B2 (en) 1986-09-25
US4603129A (en) 1986-07-29
IE50930B1 (en) 1986-08-20
CA1178271A (en) 1984-11-20

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