ES2002903A6 - Procedimiento para preparar derivados de cefalosporina - Google Patents

Procedimiento para preparar derivados de cefalosporina

Info

Publication number
ES2002903A6
ES2002903A6 ES8602966A ES8602966A ES2002903A6 ES 2002903 A6 ES2002903 A6 ES 2002903A6 ES 8602966 A ES8602966 A ES 8602966A ES 8602966 A ES8602966 A ES 8602966A ES 2002903 A6 ES2002903 A6 ES 2002903A6
Authority
ES
Spain
Prior art keywords
preparation
cephalosporin derivatives
derivatives
pharmaceutical preparations
bacterial infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602966A
Other languages
English (en)
Inventor
Rudolf Lattrell
Walter Durckheimer
Rainer Hirrstetter
Gerhard Seibert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES2002903A6 publication Critical patent/ES2002903A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CEFALOSPORINA DE FORMULA: DONDE R1 ES HIDROGENO O HALOGENO, R2 ES HIDROGENO O UN RADICAL ORGANICO SUSTITUIDO O SIN SUSTITUIR R3 ES UN RADICAL ORGANICO SUSTITUIDO O SIN SUSTITUIR Y R4 ES HIDROGENO O UN RADICAL ORGANICO, EN EL QUE SE HACE REACCIONAR UN COMPUESTO DE FORMULA: O SUS SALES, DONDE R1, R2 Y R4 SON COMO ANTES, EL GRUPO AMINO PUEDE ESTAR PROTEGIDO Y R8 ES UN GRUPO INTERCAMBIABLE POR IMIDAZOL O EL DERIVADO DE IMIDAZOL QUE CORRESPONDE A LOS RADICALES R3 DE LA FORMULA (I), CON IMIDAZOL O DICHO DERIVADO DE ESTE, SEPARANDOSE A CONTINUACION UN GRUPO PROTECTOR EVENTUALMENTE EXISTENTE Y TRANSFORMANDOSE, EN CASO NECESARIO, EL PRODUCTO RESULTANTE EN UNA SAL DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLE. OTRAS VIAS DE SINTESIS SE DESCRIBEN EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS SON ESPECIALMENTE UTILES COMO MEDICAMENTOS PARA TRATAR INFECCIONES MICROBIANAS.
ES8602966A 1985-11-11 1986-11-10 Procedimiento para preparar derivados de cefalosporina Expired ES2002903A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853539901 DE3539901A1 (de) 1985-11-11 1985-11-11 Cephalosporinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2002903A6 true ES2002903A6 (es) 1988-10-01

Family

ID=6285648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602966A Expired ES2002903A6 (es) 1985-11-11 1986-11-10 Procedimiento para preparar derivados de cefalosporina

Country Status (17)

Country Link
EP (1) EP0222322B1 (es)
JP (1) JPS62114990A (es)
KR (1) KR870004994A (es)
AT (1) ATE75746T1 (es)
AU (1) AU602131B2 (es)
DE (2) DE3539901A1 (es)
DK (1) DK536986A (es)
ES (1) ES2002903A6 (es)
FI (1) FI864537A (es)
GR (1) GR862698B (es)
HU (1) HU197018B (es)
IL (1) IL80558A0 (es)
NO (1) NO864475L (es)
NZ (1) NZ218227A (es)
PH (1) PH24103A (es)
PT (1) PT83712B (es)
ZA (1) ZA868518B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63094B1 (en) * 1987-09-14 1995-03-22 Fujisawa Pharmaceutical Co Cephem compound and a process for preparation thereof
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198350A (en) * 1980-09-25 1985-02-28 Toyama Chemical Co Ltd Cephalosporins and intermediates;pharmaceutical compositions
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds

Also Published As

Publication number Publication date
DK536986D0 (da) 1986-11-10
AU602131B2 (en) 1990-10-04
PT83712B (pt) 1989-07-31
FI864537A0 (fi) 1986-11-07
DK536986A (da) 1987-05-12
KR870004994A (ko) 1987-06-04
NZ218227A (en) 1989-01-06
IL80558A0 (en) 1987-02-27
AU6496886A (en) 1987-05-14
HU197018B (en) 1989-02-28
NO864475D0 (no) 1986-11-10
DE3685192D1 (de) 1992-06-11
GR862698B (en) 1987-03-06
FI864537A (fi) 1987-05-12
JPS62114990A (ja) 1987-05-26
PH24103A (en) 1990-03-05
HUT42492A (en) 1987-07-28
NO864475L (no) 1987-05-12
ZA868518B (en) 1987-07-29
EP0222322A2 (de) 1987-05-20
ATE75746T1 (de) 1992-05-15
DE3539901A1 (de) 1987-05-14
PT83712A (de) 1986-12-01
EP0222322A3 (en) 1988-10-05
EP0222322B1 (de) 1992-05-06

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001