ES8405405A1 - Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos - Google Patents

Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos

Info

Publication number
ES8405405A1
ES8405405A1 ES525749A ES525749A ES8405405A1 ES 8405405 A1 ES8405405 A1 ES 8405405A1 ES 525749 A ES525749 A ES 525749A ES 525749 A ES525749 A ES 525749A ES 8405405 A1 ES8405405 A1 ES 8405405A1
Authority
ES
Spain
Prior art keywords
tetrahydrothieno
pyridines
phenyl
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525749A
Other languages
English (en)
Other versions
ES525749A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Publication of ES8405405A1 publication Critical patent/ES8405405A1/es
Publication of ES525749A0 publication Critical patent/ES525749A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B17/00—Monitoring; Testing
    • H04B17/40—Monitoring; Testing of relay systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Signal Processing (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS 4-FENIL-4,5,6,7-TETRAHIDRO-TIENO 2,3-C PIRIDINAS SUSTITUIDAS CON RADICALES BASICOS.CONSISTE EN PREPARAR COMPUESTOS DE FORMULA (I) EN DONDE R1 SIGNIFICA EL GRUPO DE FORMULA (II) Y DONDE R2 Y R3, SIGNIFICAN HIDROGENO, FLUOR, CLORO, BROMO; R4 SIGNIFICA UN RADICAL ALCOHILO RECTO O RAMIFICADO CON 1-3 ATOMOS DE CARBONO; Y R5 Y R6 SIGNIFICAN HIDROGENO, RADICALES ALCOHILO CON 1-4 ATOMOS DE CARBONO O JUNTO CON EL ATOMO DE NITROGENO. SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (III), EN DONDE LOS RADICALESR2, R3 Y R4 TIENEN LOS SIGNIFICADOS ANTERIORMENTE INDICADOS Y X SIGNIFICA UNO DE LOS RADICALES CLCH2- O BRCH2-, CON LA AMINA DESEADA Y EL PRODUCTO FINAL DE FORMULA GENERAL (I) SE TRANSFORMA DE MANERA USUAL EN UNA SAL POR ADICION DE ACIDO FISIOLOGICAMENTE INOCUA.POSEE PROPIEDADES ANTIDEPRESIVAS Y EJERCE UN EFECTO TIMOLEPTICO Y ESTIMULANTE DEL SISTEMA NERVIOSO CENTRAL.
ES525749A 1982-03-05 1983-09-20 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos Granted ES525749A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823207939 DE3207939A1 (de) 1982-03-05 1982-03-05 Neue basisch substituierte 4-phenyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
ES8405405A1 true ES8405405A1 (es) 1984-06-01
ES525749A0 ES525749A0 (es) 1984-06-01

Family

ID=6157400

Family Applications (3)

Application Number Title Priority Date Filing Date
ES520314A Granted ES520314A0 (es) 1982-03-05 1983-03-04 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno (2,3-c)piridinas sustituidas con radicales basicos.
ES525749A Granted ES525749A0 (es) 1982-03-05 1983-09-20 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos
ES525750A Expired ES8405406A1 (es) 1982-03-05 1983-09-20 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES520314A Granted ES520314A0 (es) 1982-03-05 1983-03-04 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno (2,3-c)piridinas sustituidas con radicales basicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES525750A Expired ES8405406A1 (es) 1982-03-05 1983-09-20 Procedimiento para la preparacion de nuevas 4-fenil-4,5,6,7-tetrahidro-tieno(2,3-c)piridinas sustituidas con radicales basicos

Country Status (24)

Country Link
US (2) US4482559A (es)
EP (1) EP0088250B1 (es)
JP (1) JPS58162591A (es)
KR (1) KR840004110A (es)
AT (1) ATE20066T1 (es)
AU (1) AU554783B2 (es)
CA (1) CA1197506A (es)
CS (3) CS237342B2 (es)
DD (1) DD210278A5 (es)
DE (2) DE3207939A1 (es)
DK (1) DK87383A (es)
ES (3) ES520314A0 (es)
FI (1) FI74282C (es)
GB (1) GB2117762B (es)
GR (1) GR78456B (es)
HU (1) HU185193B (es)
IL (1) IL68032A (es)
NO (1) NO830758L (es)
NZ (1) NZ203471A (es)
PH (1) PH18897A (es)
PL (3) PL137768B1 (es)
PT (1) PT76335B (es)
SU (1) SU1187723A3 (es)
ZA (1) ZA831477B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570701B1 (fr) * 1984-09-27 1987-05-22 Synthelabo Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
JPS6210087A (ja) * 1985-07-03 1987-01-19 Shionogi & Co Ltd ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤
US4775757A (en) * 1986-09-22 1988-10-04 Ortho Pharmaceutical Corporation Thienopyridines useful as cardiovascular agents
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
WO1998040385A1 (en) * 1997-03-07 1998-09-17 Novo Nordisk A/S 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE
US6177443B1 (en) 1997-03-07 2001-01-23 Novo Nordisk A/S 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use
US6262044B1 (en) 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823151A (en) * 1968-08-02 1974-07-09 Ciba Geigy Corp 4,5,6,7-tetrahydrothieno(2,3-d)pyridines
US3705910A (en) * 1970-05-20 1972-12-12 Exxon Research Engineering Co N-(2-(4,5,6,7-tetrahydrobenzothienyl))-propionamides
FR2358150A1 (fr) * 1976-07-13 1978-02-10 Parcor Nouvelles thieno (2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application
DE2746443C2 (de) * 1977-10-15 1986-09-18 C.H. Boehringer Sohn, 6507 Ingelheim 4-Phenyl-thieno-[2,3-c]-piperidine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
AT368504B (de) * 1977-10-15 1982-10-25 Boehringer Sohn Ingelheim Verfahren zur herstellung neuer 4-phenyl-thieno- (2,3-c)-piperidine

Also Published As

Publication number Publication date
ES525750A0 (es) 1984-06-01
GR78456B (es) 1983-03-04
EP0088250B1 (de) 1986-05-28
ES8404357A1 (es) 1984-04-16
DD210278A5 (de) 1984-06-06
NZ203471A (en) 1985-05-31
FI830661A0 (fi) 1983-03-01
FI74282C (fi) 1988-01-11
JPS58162591A (ja) 1983-09-27
CA1197506A (en) 1985-12-03
ES520314A0 (es) 1984-04-16
AU554783B2 (en) 1986-09-04
PL245746A1 (en) 1985-03-12
GB2117762A (en) 1983-10-19
ES8405406A1 (es) 1984-06-01
US4550106A (en) 1985-10-29
IL68032A (en) 1986-01-31
GB2117762B (en) 1985-09-25
CS237341B2 (en) 1985-07-16
PL139429B1 (en) 1987-01-31
FI74282B (fi) 1987-09-30
DE3207939A1 (de) 1983-09-15
CS237342B2 (en) 1985-07-16
EP0088250A2 (de) 1983-09-14
PL138474B1 (en) 1986-09-30
US4482559A (en) 1984-11-13
KR840004110A (ko) 1984-10-06
DK87383D0 (da) 1983-02-24
PL137768B1 (en) 1986-07-31
AU1205783A (en) 1983-09-08
CS572083A2 (en) 1984-12-14
PT76335A (de) 1983-04-01
FI830661L (fi) 1983-09-06
HU185193B (en) 1984-12-28
DK87383A (da) 1983-09-06
PT76335B (de) 1986-02-03
SU1187723A3 (ru) 1985-10-23
PL240855A1 (en) 1984-06-18
CS237337B2 (en) 1985-07-16
PH18897A (en) 1985-10-30
EP0088250A3 (en) 1984-04-25
ZA831477B (en) 1984-11-28
NO830758L (no) 1983-09-06
PL245747A1 (en) 1985-01-02
GB8306033D0 (en) 1983-04-07
DE3363643D1 (en) 1986-07-03
CS137083A2 (en) 1984-12-14
ATE20066T1 (de) 1986-06-15
ES525749A0 (es) 1984-06-01
IL68032A0 (en) 1983-06-15
CS572183A2 (en) 1984-12-14

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