ES8403865A1 - Procedimiento para la preparacion de derivados de carbaciclina - Google Patents
Procedimiento para la preparacion de derivados de carbaciclinaInfo
- Publication number
- ES8403865A1 ES8403865A1 ES524058A ES524058A ES8403865A1 ES 8403865 A1 ES8403865 A1 ES 8403865A1 ES 524058 A ES524058 A ES 524058A ES 524058 A ES524058 A ES 524058A ES 8403865 A1 ES8403865 A1 ES 8403865A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- carbacicline
- derivatives
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 230000003182 bronchodilatating effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Drawers Of Furniture (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823226550 DE3226550A1 (de) | 1982-07-13 | 1982-07-13 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES524058A0 ES524058A0 (es) | 1984-04-16 |
| ES8403865A1 true ES8403865A1 (es) | 1984-04-16 |
Family
ID=6168531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES524058A Expired ES8403865A1 (es) | 1982-07-13 | 1983-07-12 | Procedimiento para la preparacion de derivados de carbaciclina |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0099538B1 (OSRAM) |
| JP (1) | JPS5921636A (OSRAM) |
| AT (1) | ATE67182T1 (OSRAM) |
| AU (1) | AU571841B2 (OSRAM) |
| CA (1) | CA1248525A (OSRAM) |
| CS (1) | CS235329B2 (OSRAM) |
| DD (1) | DD210027B3 (OSRAM) |
| DE (2) | DE3226550A1 (OSRAM) |
| DK (1) | DK163579C (OSRAM) |
| ES (1) | ES8403865A1 (OSRAM) |
| FI (1) | FI77645C (OSRAM) |
| GR (1) | GR78873B (OSRAM) |
| HU (1) | HU191057B (OSRAM) |
| IE (1) | IE57233B1 (OSRAM) |
| IL (1) | IL69199A (OSRAM) |
| NZ (1) | NZ204875A (OSRAM) |
| PH (1) | PH25119A (OSRAM) |
| SU (1) | SU1316555A3 (OSRAM) |
| ZA (1) | ZA835109B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225288A1 (de) * | 1982-07-02 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS59141536A (ja) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体 |
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4971987A (en) * | 1984-07-27 | 1990-11-20 | Schering Aktiengesellschaft | New carbacycline, process for their production and their use as a drug |
| DE3933523A1 (de) * | 1989-10-05 | 1991-04-11 | Schering Ag | Antimetastatisch wirkende mittel |
| EP0431571A3 (en) * | 1989-12-05 | 1992-01-02 | Sagami Chemical Research Center | Cis-bicyclo(4.3.0)non-2-ene derivatives |
| DE4104607A1 (de) * | 1991-02-12 | 1992-08-13 | Schering Ag | Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen |
| CN1377263A (zh) * | 1999-08-05 | 2002-10-30 | 帝人株式会社 | 含有含氮化合物作为活性成分的神经损伤治疗剂 |
| US8183286B2 (en) | 2006-11-16 | 2012-05-22 | Gemmus Pharma Inc. | EP2 and EP4 agonists as agents for the treatment of influenza a viral infection |
| WO2011047048A1 (en) | 2009-10-14 | 2011-04-21 | Gemmus Pharma, Inc. | Combination therapy treatment for viral infections |
| KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2013661B (en) * | 1978-01-26 | 1982-11-10 | Erba Farmitalia | 9-deoxy-9 -methylene isosteres of pgi2 |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| IE54303B1 (en) * | 1981-08-19 | 1989-08-16 | Merrell Dow France | Fluorinated diaminoalkene derivatives |
| GR77976B (OSRAM) * | 1982-03-12 | 1984-09-25 | Schering Ag | |
| DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1982
- 1982-07-13 DE DE19823226550 patent/DE3226550A1/de not_active Ceased
-
1983
- 1983-07-06 DD DD83252808A patent/DD210027B3/de not_active IP Right Cessation
- 1983-07-11 AT AT83106792T patent/ATE67182T1/de not_active IP Right Cessation
- 1983-07-11 EP EP83106792A patent/EP0099538B1/de not_active Expired - Lifetime
- 1983-07-11 GR GR71905A patent/GR78873B/el unknown
- 1983-07-11 AU AU16718/83A patent/AU571841B2/en not_active Ceased
- 1983-07-11 DE DE8383106792T patent/DE3382408D1/de not_active Expired - Lifetime
- 1983-07-12 JP JP58125615A patent/JPS5921636A/ja active Granted
- 1983-07-12 NZ NZ204875A patent/NZ204875A/en unknown
- 1983-07-12 ES ES524058A patent/ES8403865A1/es not_active Expired
- 1983-07-12 SU SU833615553A patent/SU1316555A3/ru active
- 1983-07-12 PH PH29208A patent/PH25119A/en unknown
- 1983-07-12 IL IL69199A patent/IL69199A/xx not_active IP Right Cessation
- 1983-07-12 HU HU832481A patent/HU191057B/hu not_active IP Right Cessation
- 1983-07-12 DK DK321283A patent/DK163579C/da not_active IP Right Cessation
- 1983-07-12 CA CA000432232A patent/CA1248525A/en not_active Expired
- 1983-07-13 ZA ZA835109A patent/ZA835109B/xx unknown
- 1983-07-13 CS CS835301A patent/CS235329B2/cs unknown
- 1983-07-13 FI FI832557A patent/FI77645C/fi not_active IP Right Cessation
- 1983-07-13 IE IE1630/83A patent/IE57233B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SU1316555A3 (ru) | 1987-06-07 |
| FI832557A0 (fi) | 1983-07-13 |
| ES524058A0 (es) | 1984-04-16 |
| PH25119A (en) | 1991-02-19 |
| IL69199A0 (en) | 1983-11-30 |
| IE57233B1 (en) | 1992-06-17 |
| DK321283A (da) | 1984-01-14 |
| DE3226550A1 (de) | 1984-01-19 |
| DD210027A5 (de) | 1984-05-30 |
| AU1671883A (en) | 1984-01-19 |
| AU571841B2 (en) | 1988-04-28 |
| DK163579C (da) | 1992-08-03 |
| ATE67182T1 (de) | 1991-09-15 |
| HU191057B (en) | 1986-12-28 |
| DE3382408D1 (de) | 1991-10-17 |
| ZA835109B (en) | 1984-08-29 |
| CS235329B2 (en) | 1985-05-15 |
| IE831630L (en) | 1984-01-13 |
| GR78873B (OSRAM) | 1984-10-02 |
| NZ204875A (en) | 1986-11-12 |
| CA1248525A (en) | 1989-01-10 |
| DK321283D0 (da) | 1983-07-12 |
| FI832557A7 (fi) | 1984-01-14 |
| JPS5921636A (ja) | 1984-02-03 |
| EP0099538A1 (de) | 1984-02-01 |
| FI77645C (fi) | 1989-04-10 |
| DK163579B (da) | 1992-03-16 |
| IL69199A (en) | 1987-08-31 |
| DD210027B3 (de) | 1990-07-18 |
| FI77645B (fi) | 1988-12-30 |
| EP0099538B1 (de) | 1991-09-11 |
| JPH0324457B2 (OSRAM) | 1991-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980924 |