IL69199A0 - Carbacyclin derivatives,process for their manufacture and pharmaceutical compositions containing them - Google Patents
Carbacyclin derivatives,process for their manufacture and pharmaceutical compositions containing themInfo
- Publication number
- IL69199A0 IL69199A0 IL69199A IL6919983A IL69199A0 IL 69199 A0 IL69199 A0 IL 69199A0 IL 69199 A IL69199 A IL 69199A IL 6919983 A IL6919983 A IL 6919983A IL 69199 A0 IL69199 A0 IL 69199A0
- Authority
- IL
- Israel
- Prior art keywords
- group
- denotes
- radical
- atoms
- hydrogen atom
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 hydroxymethylene group Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Drawers Of Furniture (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Carbacylin derivatives of the general formula I <IMAGE> in which R1 denotes a hydrogen atom or the radical OR2, in which R2 can denote hydrogen, alkyl, cycloalkyl, aryl, the radical <IMAGE> or a heterocyclic radical, or R1 can denote the radical NHR3 where R3 denotes an acid radical or the radical R2, n can denote the number 2, 3, 4 or 5, X denotes a hydrogen atom or a fluorine atom, A denotes a -CH2-CH2-, a trans -CH=CH- or -C IDENTICAL C- group, W denotes a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> group, in which the OH group can be in the alpha or beta position, D denotes the group <IMAGE> a straight-chain, saturated alkylene group having 1-5 C atoms, a branched saturated or a straight-chain or branched unsaturated alkylene group having 2-5 C atoms, which may be substituted by fluorine atoms, m can denote the number 1, 2 or 3, E represents a direct bond, a -C IDENTICAL C- group or a -CR6=CR7- group, in which R6 denotes a hydrogen atom or an alkyl group having 1-5 C atoms and R7 denotes a hydrogen atom, an alkyl group having 1-5 C atoms or a halogen atom, R4 denotes an alkyl, cycloalkyl or a substituted or unsubstituted aryl group or a heterocyclic group, R5 denotes a free or functionally modified hydroxyl group, and, if R2 denotes a hydrogen atom, the salts thereof with physiologically acceptable bases, a process for their preparation and their use as pharmaceuticals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823226550 DE3226550A1 (en) | 1982-07-13 | 1982-07-13 | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL69199A0 true IL69199A0 (en) | 1983-11-30 |
| IL69199A IL69199A (en) | 1987-08-31 |
Family
ID=6168531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL69199A IL69199A (en) | 1982-07-13 | 1983-07-12 | (5e)and (5z)-6a-carbaprostaglandin-i2-derivatives,process for their manufacture and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0099538B1 (en) |
| JP (1) | JPS5921636A (en) |
| AT (1) | ATE67182T1 (en) |
| AU (1) | AU571841B2 (en) |
| CA (1) | CA1248525A (en) |
| CS (1) | CS235329B2 (en) |
| DD (1) | DD210027B3 (en) |
| DE (2) | DE3226550A1 (en) |
| DK (1) | DK163579C (en) |
| ES (1) | ES524058A0 (en) |
| FI (1) | FI77645C (en) |
| GR (1) | GR78873B (en) |
| HU (1) | HU191057B (en) |
| IE (1) | IE57233B1 (en) |
| IL (1) | IL69199A (en) |
| NZ (1) | NZ204875A (en) |
| PH (1) | PH25119A (en) |
| SU (1) | SU1316555A3 (en) |
| ZA (1) | ZA835109B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225288A1 (en) * | 1982-07-02 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| DE3225287A1 (en) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| JPS59141536A (en) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative and preparation thereof |
| DE3405181A1 (en) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| US4971987A (en) * | 1984-07-27 | 1990-11-20 | Schering Aktiengesellschaft | New carbacycline, process for their production and their use as a drug |
| DE3933523A1 (en) * | 1989-10-05 | 1991-04-11 | Schering Ag | ANTIMETASTICALLY ACTIVE AGENTS |
| EP0431571A3 (en) * | 1989-12-05 | 1992-01-02 | Sagami Chemical Research Center | Cis-bicyclo(4.3.0)non-2-ene derivatives |
| DE4104607A1 (en) * | 1991-02-12 | 1992-08-13 | Schering Ag | PROSTACYCLIN AND CARBACYCLINE DERIVATIVES AS A MEDIUM FOR TREATING FEVERED DISEASES |
| CA2382759A1 (en) | 1999-08-05 | 2001-02-15 | Teijin Limited | Agent for the remedy of neural damage having a nitrogen-containing compound as the active ingredient |
| US8183286B2 (en) | 2006-11-16 | 2012-05-22 | Gemmus Pharma Inc. | EP2 and EP4 agonists as agents for the treatment of influenza a viral infection |
| NZ599128A (en) | 2009-10-14 | 2014-02-28 | Gemmus Pharma Inc | Combination therapy treatment for viral infections |
| JP6694385B2 (en) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | Compounds and methods for inhibiting phosphate transport |
| JP2022533251A (en) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | Combinations to lower serum phosphate in patients |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2040928B (en) * | 1978-01-26 | 1982-12-08 | Erba Farmitalia | Bicycloalkane derivatives useful as intermediates in preparing pg1 isosteres |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| DE3048906A1 (en) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| IE54303B1 (en) * | 1981-08-19 | 1989-08-16 | Merrell Dow France | Fluorinated diaminoalkene derivatives |
| GR77976B (en) * | 1982-03-12 | 1984-09-25 | Schering Ag | |
| DE3225287A1 (en) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | NEW CARBACYCLINAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
-
1982
- 1982-07-13 DE DE19823226550 patent/DE3226550A1/en not_active Ceased
-
1983
- 1983-07-06 DD DD83252808A patent/DD210027B3/en not_active IP Right Cessation
- 1983-07-11 EP EP83106792A patent/EP0099538B1/en not_active Expired - Lifetime
- 1983-07-11 AT AT83106792T patent/ATE67182T1/en not_active IP Right Cessation
- 1983-07-11 AU AU16718/83A patent/AU571841B2/en not_active Ceased
- 1983-07-11 DE DE8383106792T patent/DE3382408D1/en not_active Expired - Lifetime
- 1983-07-11 GR GR71905A patent/GR78873B/el unknown
- 1983-07-12 IL IL69199A patent/IL69199A/en not_active IP Right Cessation
- 1983-07-12 SU SU833615553A patent/SU1316555A3/en active
- 1983-07-12 HU HU832481A patent/HU191057B/en not_active IP Right Cessation
- 1983-07-12 NZ NZ204875A patent/NZ204875A/en unknown
- 1983-07-12 ES ES524058A patent/ES524058A0/en active Granted
- 1983-07-12 DK DK321283A patent/DK163579C/en not_active IP Right Cessation
- 1983-07-12 CA CA000432232A patent/CA1248525A/en not_active Expired
- 1983-07-12 JP JP58125615A patent/JPS5921636A/en active Granted
- 1983-07-12 PH PH29208A patent/PH25119A/en unknown
- 1983-07-13 CS CS835301A patent/CS235329B2/en unknown
- 1983-07-13 IE IE1630/83A patent/IE57233B1/en not_active IP Right Cessation
- 1983-07-13 FI FI832557A patent/FI77645C/en not_active IP Right Cessation
- 1983-07-13 ZA ZA835109A patent/ZA835109B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0099538B1 (en) | 1991-09-11 |
| ATE67182T1 (en) | 1991-09-15 |
| IE831630L (en) | 1984-01-13 |
| CS235329B2 (en) | 1985-05-15 |
| FI77645B (en) | 1988-12-30 |
| HU191057B (en) | 1986-12-28 |
| EP0099538A1 (en) | 1984-02-01 |
| JPS5921636A (en) | 1984-02-03 |
| DK321283D0 (en) | 1983-07-12 |
| AU1671883A (en) | 1984-01-19 |
| DE3382408D1 (en) | 1991-10-17 |
| FI832557A (en) | 1984-01-14 |
| JPH0324457B2 (en) | 1991-04-03 |
| DK321283A (en) | 1984-01-14 |
| ZA835109B (en) | 1984-08-29 |
| CA1248525A (en) | 1989-01-10 |
| GR78873B (en) | 1984-10-02 |
| PH25119A (en) | 1991-02-19 |
| SU1316555A3 (en) | 1987-06-07 |
| FI77645C (en) | 1989-04-10 |
| DD210027B3 (en) | 1990-07-18 |
| ES8403865A1 (en) | 1984-04-16 |
| DK163579C (en) | 1992-08-03 |
| NZ204875A (en) | 1986-11-12 |
| DD210027A5 (en) | 1984-05-30 |
| AU571841B2 (en) | 1988-04-28 |
| DK163579B (en) | 1992-03-16 |
| IL69199A (en) | 1987-08-31 |
| DE3226550A1 (en) | 1984-01-19 |
| IE57233B1 (en) | 1992-06-17 |
| ES524058A0 (en) | 1984-04-16 |
| FI832557A0 (en) | 1983-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |