DK573487A - CYCLODEXTRINCLATHRATES OF CARBACYCLININE DERIVATIVES AND USE THEREOF AS A MEDICINE - Google Patents

CYCLODEXTRINCLATHRATES OF CARBACYCLININE DERIVATIVES AND USE THEREOF AS A MEDICINE

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Publication number
DK573487A
DK573487A DK573487A DK573487A DK573487A DK 573487 A DK573487 A DK 573487A DK 573487 A DK573487 A DK 573487A DK 573487 A DK573487 A DK 573487A DK 573487 A DK573487 A DK 573487A
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DK
Denmark
Prior art keywords
group
atoms
image
straight
chain
Prior art date
Application number
DK573487A
Other languages
Danish (da)
Other versions
DK169432B1 (en
DK573487D0 (en
Inventor
Werner Skuballa
Helmut Vorbrueggen
Helmut Dahl
Claus-Steffen Stuerzebecher
Karl-Heinz Thierauch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3608088A external-priority patent/DE3608088C2/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK573487A publication Critical patent/DK573487A/en
Publication of DK573487D0 publication Critical patent/DK573487D0/en
Application granted granted Critical
Publication of DK169432B1 publication Critical patent/DK169432B1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Cyclodextrin clathrates of carbacyclin analogues having the general formula I <IMAGE> in which R1 is a hydrogen atom or a straight-chain or branched alkyl group having up to 10 C atoms, A is a trans-CH=CH- or a -C<IMAGE>C-group, W is a free or functionally altered hydroxymethylene group or a free or functionally altered <IMAGE> group in which the OH group can be in the α position or the β position, D is the group <IMAGE> a straight-chain, saturated alklene group having 1-5 C atoms, a branched or straight-chain or branched, unsaturated alkylene group having 2-5 C atoms which can optionally be substituted by fluorine atoms, m is the number 1, 2 or 3, E is a direct linkage, a -C=C- group or -CR4=CR5- group, in which R4 is hydrogen or an alkyl group having 1-5 C atoms, and R5 is hydrogen, halogen or an alkyl group having 1-5 C atoms, R2 is an alkyl group having 1-10 C atoms, a cycloalkyl group having 3-10 C atoms or an optionally substituted aryl group having 6-10 C atoms or a heterocyclic group, and R3 is a free or functionally changed hydroxyl group, n is the number 1, 2, 3, 4 or 5, and X is a CH2 group or an oxygen atom together with pharmaceutically acceptable carrier substances and auxiliary substances.
DK573487A 1986-03-07 1987-11-02 Cyclodextrin clathrates of carbacyclin derivatives DK169432B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3608088 1986-03-07
DE3608088A DE3608088C2 (en) 1986-03-07 1986-03-07 Pharmaceutical preparations containing cyclodextrin clathrates of carbacyclin derivatives
DE8700106 1987-03-09
PCT/DE1987/000106 WO1987005294A1 (en) 1986-03-07 1987-03-09 Cyclodextrinclathrates of carbacycline derivatives and their use as medicinal drugs

Publications (3)

Publication Number Publication Date
DK573487A true DK573487A (en) 1987-11-02
DK573487D0 DK573487D0 (en) 1987-11-02
DK169432B1 DK169432B1 (en) 1994-10-31

Family

ID=25841830

Family Applications (1)

Application Number Title Priority Date Filing Date
DK573487A DK169432B1 (en) 1986-03-07 1987-11-02 Cyclodextrin clathrates of carbacyclin derivatives

Country Status (1)

Country Link
DK (1) DK169432B1 (en)

Also Published As

Publication number Publication date
DK169432B1 (en) 1994-10-31
DK573487D0 (en) 1987-11-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired