ZA837452B - Novel 5-fluoro-carbacyclins,process for their manufacture and their use as medicaments - Google Patents
Novel 5-fluoro-carbacyclins,process for their manufacture and their use as medicamentsInfo
- Publication number
- ZA837452B ZA837452B ZA837452A ZA837452A ZA837452B ZA 837452 B ZA837452 B ZA 837452B ZA 837452 A ZA837452 A ZA 837452A ZA 837452 A ZA837452 A ZA 837452A ZA 837452 B ZA837452 B ZA 837452B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- denotes
- image
- radical
- atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 150000003254 radicals Chemical class 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 alkyl radical Chemical class 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
5-Fluorocarbacyclin derivatives of the general formula I <IMAGE> in which R1 denotes the radical CH2OH or <IMAGE> with R2 denoting a hydrogen atom, an alkyl radical, cycloalkyl, aryl, or a <IMAGE> or heterocyclic radical or R1 denotes the radical <IMAGE> with R3 denoting an alkanoyl or alkanesulphonyl radical each having 1-10 C atoms or the radical R2 or R1 denotes the radical <IMAGE> in which m denotes the number 1 or 2, A denotes a -CH2-CH2-, a trans-CH=CH- or -C IDENTICAL C- group, W denotes a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> it being possible for the OH group to be in the alpha - or beta -position, D denotes the group <IMAGE> a straight-chain saturated alkylene group having 1-5 C atoms, a branched saturated or a straight-chain or branched unsaturated alkylene group having 2-5 C atoms, which can optionally be substituted by fluorine atoms, n may denote the number 1, 2 or 3, E represents a direct bond, a -C IDENTICAL C- group or a -CR6=CR7- group, R6 denoting a hydrogen atom or an alkyl group having 1-5 C atoms and R7 denoting a hydrogen atom, a halogen atom or an alkyl group having 1-5 C atoms, R4 denotes an alkyl, cycloalkyl or an optionally substituted aryl group or a heterocyclic group, R5 denotes a free or functionally modified hydroxyl group, and if R2 has the meaning of a hydrogen atom, their salts with physiologically tolerable bases, process for their preparation and their pharmaceutical use.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823237200 DE3237200A1 (en) | 1982-10-05 | 1982-10-05 | 5-FLUORCARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA837452B true ZA837452B (en) | 1984-06-27 |
Family
ID=6175192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA837452A ZA837452B (en) | 1982-10-05 | 1983-10-05 | Novel 5-fluoro-carbacyclins,process for their manufacture and their use as medicaments |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0113311B1 (en) |
| JP (1) | JPS59134739A (en) |
| AT (1) | ATE71087T1 (en) |
| AU (1) | AU576477B2 (en) |
| CA (1) | CA1250834A (en) |
| DE (2) | DE3237200A1 (en) |
| DK (1) | DK459783A (en) |
| ES (1) | ES8405355A1 (en) |
| GR (1) | GR78728B (en) |
| HU (1) | HU191111B (en) |
| ZA (1) | ZA837452B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4971987A (en) * | 1984-07-27 | 1990-11-20 | Schering Aktiengesellschaft | New carbacycline, process for their production and their use as a drug |
| DE102004021319B4 (en) * | 2004-04-30 | 2010-11-11 | Siemens Ag | Setup of multihop communication connections depending on limit values |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
| US4338457A (en) * | 1980-02-28 | 1982-07-06 | The Upjohn Company | Composition and process |
| DE3104044A1 (en) * | 1981-02-02 | 1982-08-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | NEW PROSTACYCLIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
-
1982
- 1982-10-05 DE DE19823237200 patent/DE3237200A1/en not_active Withdrawn
-
1983
- 1983-09-30 AU AU19804/83A patent/AU576477B2/en not_active Ceased
- 1983-10-03 GR GR72607A patent/GR78728B/el unknown
- 1983-10-04 AT AT83730094T patent/ATE71087T1/en not_active IP Right Cessation
- 1983-10-04 CA CA000438346A patent/CA1250834A/en not_active Expired
- 1983-10-04 ES ES526227A patent/ES8405355A1/en not_active Expired
- 1983-10-04 EP EP83730094A patent/EP0113311B1/en not_active Expired - Lifetime
- 1983-10-04 DE DE8383730094T patent/DE3382489D1/en not_active Expired - Lifetime
- 1983-10-04 HU HU833441A patent/HU191111B/en not_active IP Right Cessation
- 1983-10-05 JP JP58185225A patent/JPS59134739A/en active Granted
- 1983-10-05 ZA ZA837452A patent/ZA837452B/en unknown
- 1983-10-05 DK DK459783A patent/DK459783A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3237200A1 (en) | 1984-04-05 |
| EP0113311B1 (en) | 1992-01-02 |
| EP0113311A1 (en) | 1984-07-11 |
| JPS59134739A (en) | 1984-08-02 |
| JPH0510330B2 (en) | 1993-02-09 |
| DK459783D0 (en) | 1983-10-05 |
| GR78728B (en) | 1984-10-02 |
| AU576477B2 (en) | 1988-09-01 |
| ATE71087T1 (en) | 1992-01-15 |
| CA1250834A (en) | 1989-03-07 |
| DK459783A (en) | 1984-04-06 |
| ES526227A0 (en) | 1984-06-16 |
| HU191111B (en) | 1987-01-28 |
| ES8405355A1 (en) | 1984-06-16 |
| DE3382489D1 (en) | 1992-02-13 |
| AU1980483A (en) | 1984-04-12 |
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