AR241474A1 - Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina. - Google Patents

Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina.

Info

Publication number
AR241474A1
AR241474A1 AR83294785A AR29478583A AR241474A1 AR 241474 A1 AR241474 A1 AR 241474A1 AR 83294785 A AR83294785 A AR 83294785A AR 29478583 A AR29478583 A AR 29478583A AR 241474 A1 AR241474 A1 AR 241474A1
Authority
AR
Argentina
Prior art keywords
preparation
amino acids
well
derivatives
intermediates
Prior art date
Application number
AR83294785A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of AR241474A1 publication Critical patent/AR241474A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

PREPARACION DE DERIVADOS DE ACIDO 3-ACILTRICICLO ¡5.2.1.0(2.6)¿-3-AZADECAN- 4-CARBOXILICO, DE FORMULA I DONDE N = 0 O 1; R = H O BENCILO; R1 = ALCOHILO SUSTITUIDO O NO CON AMINO O ACILAMINO O BENCILOXICARBONILAMINO; R2 = H O ALQUILO; Y = H; Z = H, O Y Y Z = CONJUNTAMENTE OXIGENO, ASI COMO SUS SALES FISIOLOGICAMENTE INOCUAS, SE HACE REACCIONAR UN COMPUESTO DE FORMULA II: DONDE N, R1, R2, YY Z SON LOS VALORES YA INDICADOS, CON UN COMPUESTO DE FORMULA III, DONDE W = H O BENCILO, SE SEPARAN A CONTINUACION W POR HIDROGENACION Y/O R2 = ALQUILO POR TRATAMIENTO CON UN ACIDO O UNA BASE.
AR83294785A 1982-11-13 1983-11-11 Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina. AR241474A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823242151 DE3242151A1 (de) 1982-11-13 1982-11-13 Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
AR241474A1 true AR241474A1 (es) 1992-07-31

Family

ID=6178144

Family Applications (2)

Application Number Title Priority Date Filing Date
AR83294785A AR241474A1 (es) 1982-11-13 1983-11-11 Preparacion de derivados de acido 3-aciltriciclo ¡5.2.1.0(2.6)¿-3-azadecan-4-carboxilico utiles como inhibidores de la enzima convertidora en angiotensina.
AR85300427A AR243506A1 (es) 1982-11-13 1985-05-17 Procedimiento para la preparacion de nuevos derivados de aminoacidos triciclicos con un sistema de anillo azatriciclodecano e intermediarios para su exclusivo uso en dicho procedimiento.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR85300427A AR243506A1 (es) 1982-11-13 1985-05-17 Procedimiento para la preparacion de nuevos derivados de aminoacidos triciclicos con un sistema de anillo azatriciclodecano e intermediarios para su exclusivo uso en dicho procedimiento.

Country Status (22)

Country Link
US (2) US4558065A (es)
EP (1) EP0109020B1 (es)
JP (1) JPS59101463A (es)
KR (1) KR910000255B1 (es)
AR (2) AR241474A1 (es)
AT (1) ATE29889T1 (es)
AU (2) AU565264B2 (es)
CA (1) CA1246554A (es)
DE (2) DE3242151A1 (es)
DK (1) DK160983C (es)
ES (3) ES8406438A1 (es)
FI (1) FI79116C (es)
GR (1) GR78734B (es)
HU (1) HU188978B (es)
IE (1) IE56230B1 (es)
IL (1) IL70207A (es)
MA (1) MA19951A1 (es)
NO (1) NO165148C (es)
NZ (1) NZ206236A (es)
PH (1) PH19675A (es)
PT (1) PT77652B (es)
ZA (1) ZA838378B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2004092132A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
MXPA05010165A (es) * 2003-04-15 2005-11-16 Warner Lambert Co Derivados de prolina biciclicos [c]-condensados y su uso para el tratamiento de estados artriticos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060626A (en) * 1972-01-26 1977-11-29 Boehringer Mannheim G.M.B.H. Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3118191A1 (de) * 1981-05-08 1982-11-25 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4431644A (en) * 1982-03-08 1984-02-14 Schering Corporation Antihypertensive agents
US4431645A (en) * 1982-03-08 1984-02-14 Schering Corporation Antihypertensive agents
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung

Also Published As

Publication number Publication date
FI834131A (fi) 1984-05-14
AU2119783A (en) 1984-05-17
DK516583D0 (da) 1983-11-11
FI79116B (fi) 1989-07-31
PT77652B (de) 1986-04-17
ATE29889T1 (de) 1987-10-15
DE3373818D1 (en) 1987-10-29
AR243506A1 (es) 1993-08-31
AU565264B2 (en) 1987-09-10
EP0109020A3 (en) 1985-07-17
ES8500229A1 (es) 1984-10-01
AU6859787A (en) 1987-05-07
HU188978B (en) 1986-05-28
ES529030A0 (es) 1984-10-01
KR840006623A (ko) 1984-12-01
FI834131A0 (fi) 1983-11-10
GR78734B (es) 1984-10-02
DK160983B (da) 1991-05-13
IE56230B1 (en) 1991-05-22
DK160983C (da) 1991-10-28
NO165148B (no) 1990-09-24
DK516583A (da) 1984-05-14
ES527182A0 (es) 1984-08-01
US4558065A (en) 1985-12-10
NO834128L (no) 1984-05-14
ES8406438A1 (es) 1984-08-01
EP0109020A2 (de) 1984-05-23
ZA838378B (en) 1984-06-27
KR910000255B1 (ko) 1991-01-23
CA1246554A (en) 1988-12-13
DE3242151A1 (de) 1984-05-17
JPS59101463A (ja) 1984-06-12
ES529037A0 (es) 1984-10-01
NZ206236A (en) 1988-03-30
EP0109020B1 (de) 1987-09-23
FI79116C (fi) 1989-11-10
JPH0472839B2 (es) 1992-11-19
MA19951A1 (fr) 1984-07-01
NO165148C (no) 1991-01-09
ES8500230A1 (es) 1984-10-01
AU584273B2 (en) 1989-05-18
PH19675A (en) 1986-06-09
PT77652A (de) 1983-12-01
IL70207A (en) 1988-12-30
IE832633L (en) 1984-05-13
IL70207A0 (en) 1984-02-29
US4614805A (en) 1986-09-30

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