AR246957A1 - Procedimiento para la preparacion de derivados condensados de azepinona y azocinona y procedimientos para obtener agentes que los contienen, y productos intermedios. - Google Patents
Procedimiento para la preparacion de derivados condensados de azepinona y azocinona y procedimientos para obtener agentes que los contienen, y productos intermedios.Info
- Publication number
- AR246957A1 AR246957A1 AR88310062A AR31006288A AR246957A1 AR 246957 A1 AR246957 A1 AR 246957A1 AR 88310062 A AR88310062 A AR 88310062A AR 31006288 A AR31006288 A AR 31006288A AR 246957 A1 AR246957 A1 AR 246957A1
- Authority
- AR
- Argentina
- Prior art keywords
- azocinone
- derivatives
- preparation
- well
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS CONSENSADOS DE AZEPINONA Y AZOCINONA DE FORMULA (I) EN QUE M ES 1 O 2 Y N ES 1 O 2, R3 Y R4 SON HIDROGENO, ALQUILO, ALQUENILO O ARIL-ALQUILO, QUE EN LA PARTE ARILO PUEDE ESTAR MONOSUSTITUIDO CON METOXI O NITRO; X ES CICLOALQUILO O FENILO ASI COMO SUS SALES FISIOLOGICAMENTE INOCUOS, DONDE SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II), EN QUE N, R4, X, Y Y Z ESTAN DEFINIDOS COMO ANTERIORMENTE, PERO R4 NO ES HIDROGEONO Y V ES UN GRUPO LABIL SUSTITUIBLE NUCLEOFILICAMENTE, CON UN COMPUESTO DE FORMULA (III) EN LA QUE M Y R3 ESTAN DEFINIDOS COMO ANTERIORMENTE, PERO R3 NO ES HIDROGENO, Y LOS COMPUESTOS DE FORMULA (I), OBTENIDOS DE ESTA MANERA, SE TRANSFORMAN EVENTUALMENTE EN SUS SALES FISIOLOGICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873704661 DE3704661A1 (de) | 1987-02-14 | 1987-02-14 | Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR246957A1 true AR246957A1 (es) | 1994-10-31 |
Family
ID=6320980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR88310062A AR246957A1 (es) | 1987-02-14 | 1988-02-11 | Procedimiento para la preparacion de derivados condensados de azepinona y azocinona y procedimientos para obtener agentes que los contienen, y productos intermedios. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4857520A (es) |
| EP (1) | EP0279350B1 (es) |
| JP (1) | JP2638034B2 (es) |
| KR (1) | KR960011376B1 (es) |
| AR (1) | AR246957A1 (es) |
| AT (1) | ATE97913T1 (es) |
| AU (1) | AU610124B2 (es) |
| CA (1) | CA1313371C (es) |
| CZ (1) | CZ280148B6 (es) |
| DD (1) | DD279877A5 (es) |
| DE (2) | DE3704661A1 (es) |
| DK (1) | DK172553B1 (es) |
| ES (1) | ES2061531T3 (es) |
| FI (1) | FI86849C (es) |
| HU (2) | HU208425B (es) |
| IE (1) | IE62354B1 (es) |
| IL (1) | IL85406A (es) |
| JO (1) | JO1524B1 (es) |
| MA (1) | MA21181A1 (es) |
| MX (1) | MX174166B (es) |
| NO (1) | NO176763C (es) |
| NZ (1) | NZ223500A (es) |
| PH (1) | PH25186A (es) |
| PT (1) | PT86748B (es) |
| TN (1) | TNSN88010A1 (es) |
| ZA (1) | ZA88991B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| TR200200515T2 (tr) * | 1999-08-30 | 2002-11-21 | Aventis Pharma Deutschland Gmbh | Renin-anjiyotensin sistem önleyicilerinin kardiyovasküler vakaların engellenmesinde kullanılması. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354146A (en) * | 1967-11-21 | Process for the production of cyclo- pentano omega-oenantholactam | ||
| US4141893A (en) * | 1976-11-02 | 1979-02-27 | Eli Lilly And Company | Decahydrocyclopent[c]azepines |
| CY1403A (en) * | 1981-08-11 | 1987-12-18 | Ciba Geigy Ag | Benzazepin-2-ones |
| DE3373469D1 (en) * | 1982-09-30 | 1987-10-15 | Merck & Co Inc | 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents |
| US4470988A (en) * | 1983-02-10 | 1984-09-11 | Ciba-Geigy Corporation | Benzazocinone and benzazoninone derivatives, and their pharmaceutical use |
| DE3426720A1 (de) * | 1984-07-20 | 1986-01-23 | Hoechst Ag, 6230 Frankfurt | Benzthiazepinon- und benzthiazocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung |
-
1987
- 1987-02-14 DE DE19873704661 patent/DE3704661A1/de not_active Withdrawn
-
1988
- 1988-02-11 JO JO19881524A patent/JO1524B1/en active
- 1988-02-11 AT AT88101975T patent/ATE97913T1/de not_active IP Right Cessation
- 1988-02-11 PT PT86748A patent/PT86748B/pt not_active IP Right Cessation
- 1988-02-11 FI FI880632A patent/FI86849C/fi not_active IP Right Cessation
- 1988-02-11 EP EP88101975A patent/EP0279350B1/de not_active Expired - Lifetime
- 1988-02-11 ES ES88101975T patent/ES2061531T3/es not_active Expired - Lifetime
- 1988-02-11 AR AR88310062A patent/AR246957A1/es active
- 1988-02-11 DE DE88101975T patent/DE3885914D1/de not_active Expired - Lifetime
- 1988-02-12 TN TNTNSN88010A patent/TNSN88010A1/fr unknown
- 1988-02-12 CA CA000558818A patent/CA1313371C/en not_active Expired - Fee Related
- 1988-02-12 MX MX010408A patent/MX174166B/es unknown
- 1988-02-12 JP JP63029043A patent/JP2638034B2/ja not_active Expired - Lifetime
- 1988-02-12 PH PH36490A patent/PH25186A/en unknown
- 1988-02-12 AU AU11672/88A patent/AU610124B2/en not_active Ceased
- 1988-02-12 DK DK198800724A patent/DK172553B1/da not_active IP Right Cessation
- 1988-02-12 CZ CS88892A patent/CZ280148B6/cs not_active IP Right Cessation
- 1988-02-12 NZ NZ223500A patent/NZ223500A/en unknown
- 1988-02-12 IE IE39088A patent/IE62354B1/en not_active IP Right Cessation
- 1988-02-12 HU HU8621A patent/HU208425B/hu not_active IP Right Cessation
- 1988-02-12 IL IL85406A patent/IL85406A/xx not_active IP Right Cessation
- 1988-02-12 NO NO880628A patent/NO176763C/no not_active IP Right Cessation
- 1988-02-12 DD DD88312878A patent/DD279877A5/de not_active IP Right Cessation
- 1988-02-12 HU HU88689A patent/HU203727B/hu not_active IP Right Cessation
- 1988-02-12 US US07/155,595 patent/US4857520A/en not_active Expired - Lifetime
- 1988-02-12 MA MA21418A patent/MA21181A1/fr unknown
- 1988-02-12 ZA ZA880991A patent/ZA88991B/xx unknown
- 1988-02-13 KR KR1019880001437A patent/KR960011376B1/ko not_active IP Right Cessation
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