ES8507498A1 - Un procedimiento para la preparacion de acidos fenilquinolin-carboxilicos. - Google Patents
Un procedimiento para la preparacion de acidos fenilquinolin-carboxilicos.Info
- Publication number
- ES8507498A1 ES8507498A1 ES534509A ES534509A ES8507498A1 ES 8507498 A1 ES8507498 A1 ES 8507498A1 ES 534509 A ES534509 A ES 534509A ES 534509 A ES534509 A ES 534509A ES 8507498 A1 ES8507498 A1 ES 8507498A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- antitumor agents
- phenylquinolinecarboxylic
- acids
- phenylquinolinecarboxylic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS FENILQUINOLINCARBOXILICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R3-R8 PUEDEN SER VARIOS TIPOS DE RADICALES.COMPRENDE LA REACCION DE UNA ISOTINA ADECUADAMENTE SUSTITUIDA, DE FORMULA (II), CON UNA CETONA SUSTITUIDA DE FORMULA (III), EN LAS QUE X1 Y X2 SON SUSTITUYENTES NO ESPECIFICADOS, Y R Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), EN UN DISOLVENTE TAL COMO ETANOL, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA ENTRE 25JC Y EL PUNTO DE EBULLICION DEL DISOLVENTE; SEGUIDA DE ACIDIFICACION CON ACIDO CLORHIDRICO O ACIDO ACETICO; Y FORMACION OPCIONAL DE LA SAL O EL ESTER.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES INHIBIDORES DE LOS TUMORES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51631983A | 1983-07-22 | 1983-07-22 | |
| US60510484A | 1984-04-30 | 1984-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES534509A0 ES534509A0 (es) | 1985-09-01 |
| ES8507498A1 true ES8507498A1 (es) | 1985-09-01 |
Family
ID=27058797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES534509A Expired ES8507498A1 (es) | 1983-07-22 | 1984-07-20 | Un procedimiento para la preparacion de acidos fenilquinolin-carboxilicos. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0133244B1 (es) |
| AU (1) | AU583793B2 (es) |
| CA (1) | CA1288436C (es) |
| DE (1) | DE3483704D1 (es) |
| DK (1) | DK358784A (es) |
| ES (1) | ES8507498A1 (es) |
| FI (1) | FI86987C (es) |
| GR (1) | GR82234B (es) |
| HK (1) | HK142395A (es) |
| HU (1) | HU194832B (es) |
| IE (1) | IE57627B1 (es) |
| IL (1) | IL72471A (es) |
| NO (1) | NO167510C (es) |
| NZ (1) | NZ208966A (es) |
| PT (1) | PT78960B (es) |
| SU (2) | SU1393314A3 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889862A (en) * | 1986-08-28 | 1989-12-26 | E. I. Du Pont De Nemours And Company | Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids |
| WO1989006227A1 (en) * | 1987-12-28 | 1989-07-13 | The Dow Chemical Company | Phenoxyphenoxypropionates, intermediates thereof and methods of preparation |
| US4861783A (en) * | 1988-04-26 | 1989-08-29 | E. I. Du Pont De Nemours And Company | 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases |
| US4968702A (en) * | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| DE3905339A1 (de) * | 1989-02-22 | 1990-09-06 | Basf Ag | Chinolin-4-carbonsaeurederivate und deren verwendung |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| EP1001945B1 (en) * | 1997-05-28 | 2011-03-02 | Aventis Pharmaceuticals Inc. | QUINOLINE AND QUINOXALINE COMPOUNDS WHICH INHIBIT PLATELET-DERIVED GROWTH FACTOR AND/OR p56lck TYROSINE KINASES |
| ZA9811672B (en) * | 1997-12-19 | 2000-06-19 | Lilly Co Eli | Hypoglycemic imidazoline compounds. |
| US20060111368A1 (en) * | 2002-06-26 | 2006-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| US8232310B2 (en) * | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| CA2869513C (en) | 2012-04-12 | 2020-07-07 | Georgetown University | Methods and compositions for treating ewings sarcoma family of tumors |
| KR20160065986A (ko) | 2013-10-24 | 2016-06-09 | 조지타운 유니버시티 | 암 치료용 방법 및 조성물 |
| MX2016006678A (es) | 2013-11-22 | 2016-09-13 | Genzyme Corp | Nuevos metodos para tratar enfermedades neurodegenerativas. |
| EP3204376B1 (en) | 2014-10-09 | 2023-04-19 | Oncternal Therapeutics, Inc. | Indolinone compounds and uses thereof |
| KR102514814B1 (ko) | 2016-03-31 | 2023-03-27 | 온크터널 테라퓨틱스, 인코포레이티드. | 인돌린 유사체 및 이의 용도 |
| WO2018022771A1 (en) | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indolinone compounds |
| CN115361948A (zh) * | 2019-12-26 | 2022-11-18 | 俄亥俄州国家创新基金会 | 抑制二氢乳清酸脱氢酶的方法和组合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE502610A (es) * | 1950-04-18 | |||
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
-
1984
- 1984-07-19 DE DE8484108523T patent/DE3483704D1/de not_active Expired - Lifetime
- 1984-07-19 EP EP84108523A patent/EP0133244B1/en not_active Expired - Lifetime
- 1984-07-19 AU AU30852/84A patent/AU583793B2/en not_active Ceased
- 1984-07-19 CA CA000459263A patent/CA1288436C/en not_active Expired - Lifetime
- 1984-07-20 NO NO842969A patent/NO167510C/no unknown
- 1984-07-20 DK DK358784A patent/DK358784A/da not_active Application Discontinuation
- 1984-07-20 NZ NZ208966A patent/NZ208966A/en unknown
- 1984-07-20 ES ES534509A patent/ES8507498A1/es not_active Expired
- 1984-07-20 HU HU842824A patent/HU194832B/hu not_active IP Right Cessation
- 1984-07-20 FI FI842928A patent/FI86987C/fi not_active IP Right Cessation
- 1984-07-20 IL IL72471A patent/IL72471A/xx not_active IP Right Cessation
- 1984-07-20 SU SU843776940A patent/SU1393314A3/ru active
- 1984-07-20 IE IE1873/84A patent/IE57627B1/en not_active IP Right Cessation
- 1984-07-20 GR GR75386A patent/GR82234B/el unknown
- 1984-07-20 PT PT78960A patent/PT78960B/pt not_active IP Right Cessation
-
1986
- 1986-01-06 SU SU864000869A patent/SU1452480A3/ru active
-
1995
- 1995-09-07 HK HK142395A patent/HK142395A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU583793B2 (en) | 1989-05-11 |
| HU194832B (en) | 1988-03-28 |
| DK358784A (da) | 1985-01-23 |
| FI86987B (fi) | 1992-07-31 |
| PT78960A (en) | 1984-08-01 |
| ES534509A0 (es) | 1985-09-01 |
| IE57627B1 (en) | 1993-02-10 |
| HUT35248A (en) | 1985-06-28 |
| FI842928A0 (fi) | 1984-07-20 |
| DK358784D0 (da) | 1984-07-20 |
| PT78960B (en) | 1986-10-20 |
| NZ208966A (en) | 1986-12-05 |
| NO167510C (no) | 1991-11-13 |
| IE841873L (en) | 1985-01-22 |
| DE3483704D1 (de) | 1991-01-17 |
| EP0133244A2 (en) | 1985-02-20 |
| SU1452480A3 (ru) | 1989-01-15 |
| IL72471A (en) | 1988-11-15 |
| CA1288436C (en) | 1991-09-03 |
| EP0133244A3 (en) | 1985-12-11 |
| GR82234B (es) | 1984-12-13 |
| NO842969L (no) | 1985-01-23 |
| SU1393314A3 (ru) | 1988-04-30 |
| NO167510B (no) | 1991-08-05 |
| HK142395A (en) | 1995-09-15 |
| FI842928A (fi) | 1985-01-23 |
| FI86987C (fi) | 1992-11-10 |
| AU3085284A (en) | 1985-01-24 |
| IL72471A0 (en) | 1984-11-30 |
| EP0133244B1 (en) | 1990-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20020401 |