PT78960B - Process for preparing phenylquinolinecarboxylic acids and derivatives thereof useful as antitumor agents and of pharmaceutical compositions containing the same - Google Patents
Process for preparing phenylquinolinecarboxylic acids and derivatives thereof useful as antitumor agents and of pharmaceutical compositions containing the sameInfo
- Publication number
- PT78960B PT78960B PT78960A PT7896084A PT78960B PT 78960 B PT78960 B PT 78960B PT 78960 A PT78960 A PT 78960A PT 7896084 A PT7896084 A PT 7896084A PT 78960 B PT78960 B PT 78960B
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- preparing
- useful
- pharmaceutical compositions
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51631983A | 1983-07-22 | 1983-07-22 | |
| US60510484A | 1984-04-30 | 1984-04-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT78960A PT78960A (en) | 1984-08-01 |
| PT78960B true PT78960B (en) | 1986-10-20 |
Family
ID=27058797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT78960A PT78960B (en) | 1983-07-22 | 1984-07-20 | Process for preparing phenylquinolinecarboxylic acids and derivatives thereof useful as antitumor agents and of pharmaceutical compositions containing the same |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0133244B1 (pt) |
| AU (1) | AU583793B2 (pt) |
| CA (1) | CA1288436C (pt) |
| DE (1) | DE3483704D1 (pt) |
| DK (1) | DK358784A (pt) |
| ES (1) | ES534509A0 (pt) |
| FI (1) | FI86987C (pt) |
| GR (1) | GR82234B (pt) |
| HK (1) | HK142395A (pt) |
| HU (1) | HU194832B (pt) |
| IE (1) | IE57627B1 (pt) |
| IL (1) | IL72471A (pt) |
| NO (1) | NO167510C (pt) |
| NZ (1) | NZ208966A (pt) |
| PT (1) | PT78960B (pt) |
| SU (2) | SU1393314A3 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889862A (en) * | 1986-08-28 | 1989-12-26 | E. I. Du Pont De Nemours And Company | Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids |
| AU611255B2 (en) * | 1987-12-28 | 1991-06-06 | Dowelanco | Phenoxyphenoxypropionates, intermediates thereof and methods of preparation |
| US4861783A (en) * | 1988-04-26 | 1989-08-29 | E. I. Du Pont De Nemours And Company | 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases |
| US4968702A (en) * | 1989-01-17 | 1990-11-06 | American Cyanamid Company | Substituted quinolinecarboxylic acids |
| US4918077A (en) * | 1989-01-25 | 1990-04-17 | E. I. Du Pont De Nemours & Co., Inc. | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
| DE3905339A1 (de) * | 1989-02-22 | 1990-09-06 | Basf Ag | Chinolin-4-carbonsaeurederivate und deren verwendung |
| US5393891A (en) * | 1993-06-08 | 1995-02-28 | The Du Pont Merck Pharmaceutical Company | Immunoassay reagents and methods for detecting brequinar and analogs |
| IL133007A (en) * | 1997-05-28 | 2005-06-19 | Aventis Pharma Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| ATE239013T1 (de) * | 1997-12-19 | 2003-05-15 | Lilly Co Eli | Hypoglykamische imidazoline derivate |
| WO2004002484A1 (ja) * | 2002-06-26 | 2004-01-08 | Kyowa Hakko Kogyo Co., Ltd. | ホスホジエステラーゼ阻害剤 |
| US8232310B2 (en) * | 2006-12-29 | 2012-07-31 | Georgetown University | Targeting of EWS-FLI1 as anti-tumor therapy |
| IN2014DN09228A (pt) | 2012-04-12 | 2015-07-10 | Univ Georgetown | |
| US9511050B2 (en) | 2013-10-24 | 2016-12-06 | Georgetown University | Methods and compositions for treating cancer |
| US20160287549A1 (en) | 2013-11-22 | 2016-10-06 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
| JP6654197B2 (ja) | 2014-10-09 | 2020-02-26 | オンターナル セラピューティック インコーポレイテッドＯｎｃｔｅｒｎａｌ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | インドリノン化合物及びその使用 |
| ES2823190T3 (es) | 2016-03-31 | 2021-05-06 | Oncternal Therapeutics Inc | Análogos de indolina y usos de los mismos |
| WO2018022771A1 (en) | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indolinone compounds |
| JP2023512413A (ja) * | 2019-12-26 | 2023-03-27 | オハイオ ステート イノベーション ファウンデーション | ジヒドロオロト酸デヒドロゲナーゼの阻害のための方法および組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE502610A (pt) * | 1950-04-18 | |||
| US2888346A (en) * | 1955-08-22 | 1959-05-26 | Gen Aniline & Film Corp | Ultra-violet absorbing compounds |
-
1984
- 1984-07-19 CA CA000459263A patent/CA1288436C/en not_active Expired - Lifetime
- 1984-07-19 EP EP84108523A patent/EP0133244B1/en not_active Expired - Lifetime
- 1984-07-19 DE DE8484108523T patent/DE3483704D1/de not_active Expired - Lifetime
- 1984-07-19 AU AU30852/84A patent/AU583793B2/en not_active Ceased
- 1984-07-20 NO NO842969A patent/NO167510C/no unknown
- 1984-07-20 NZ NZ208966A patent/NZ208966A/en unknown
- 1984-07-20 FI FI842928A patent/FI86987C/fi not_active IP Right Cessation
- 1984-07-20 DK DK358784A patent/DK358784A/da not_active Application Discontinuation
- 1984-07-20 ES ES534509A patent/ES534509A0/es active Granted
- 1984-07-20 HU HU842824A patent/HU194832B/hu not_active IP Right Cessation
- 1984-07-20 PT PT78960A patent/PT78960B/pt not_active IP Right Cessation
- 1984-07-20 GR GR75386A patent/GR82234B/el unknown
- 1984-07-20 IE IE1873/84A patent/IE57627B1/en not_active IP Right Cessation
- 1984-07-20 SU SU843776940A patent/SU1393314A3/ru active
- 1984-07-20 IL IL72471A patent/IL72471A/xx not_active IP Right Cessation
-
1986
- 1986-01-06 SU SU864000869A patent/SU1452480A3/ru active
-
1995
- 1995-09-07 HK HK142395A patent/HK142395A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3483704D1 (de) | 1991-01-17 |
| DK358784D0 (da) | 1984-07-20 |
| AU583793B2 (en) | 1989-05-11 |
| PT78960A (en) | 1984-08-01 |
| FI86987B (fi) | 1992-07-31 |
| HU194832B (en) | 1988-03-28 |
| ES8507498A1 (es) | 1985-09-01 |
| IE841873L (en) | 1985-01-22 |
| HUT35248A (en) | 1985-06-28 |
| EP0133244B1 (en) | 1990-12-05 |
| IE57627B1 (en) | 1993-02-10 |
| FI842928A0 (fi) | 1984-07-20 |
| HK142395A (en) | 1995-09-15 |
| FI86987C (fi) | 1992-11-10 |
| NO167510C (no) | 1991-11-13 |
| EP0133244A3 (en) | 1985-12-11 |
| NO842969L (no) | 1985-01-23 |
| DK358784A (da) | 1985-01-23 |
| AU3085284A (en) | 1985-01-24 |
| FI842928A (fi) | 1985-01-23 |
| SU1393314A3 (ru) | 1988-04-30 |
| NZ208966A (en) | 1986-12-05 |
| GR82234B (pt) | 1984-12-13 |
| IL72471A0 (en) | 1984-11-30 |
| NO167510B (no) | 1991-08-05 |
| ES534509A0 (es) | 1985-09-01 |
| IL72471A (en) | 1988-11-15 |
| SU1452480A3 (ru) | 1989-01-15 |
| EP0133244A2 (en) | 1985-02-20 |
| CA1288436C (en) | 1991-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC3A | Transfer or assignment |
Free format text: 920721 DU PONT MERCK PHARMACEUTICAL COMPANY, THE US |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000430 |