ES8403489A1 - Un procedimiento para la preparacion de derivados del acido penicilanico. - Google Patents
Un procedimiento para la preparacion de derivados del acido penicilanico.Info
- Publication number
- ES8403489A1 ES8403489A1 ES518912A ES518912A ES8403489A1 ES 8403489 A1 ES8403489 A1 ES 8403489A1 ES 518912 A ES518912 A ES 518912A ES 518912 A ES518912 A ES 518912A ES 8403489 A1 ES8403489 A1 ES 8403489A1
- Authority
- ES
- Spain
- Prior art keywords
- beta
- lactamase inhibitors
- esters
- methanediol
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- LLAPDLPYIYKTGQ-UHFFFAOYSA-N 1-aminoethyl Chemical group C[CH]N LLAPDLPYIYKTGQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
- 229960003022 amoxicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000006289 hydroxybenzyl group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- CKFGINPQOCXMAZ-UHFFFAOYSA-N methanediol Chemical class OCO CKFGINPQOCXMAZ-UHFFFAOYSA-N 0.000 abstract 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 abstract 1
- 229960005256 sulbactam Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000002132 β-lactam antibiotic Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33879782A | 1982-01-11 | 1982-01-11 | |
| US38832482A | 1982-06-14 | 1982-06-14 | |
| US06/388,323 US4427678A (en) | 1982-01-11 | 1982-06-14 | 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors |
| US06/434,371 US4452796A (en) | 1982-06-14 | 1982-10-21 | 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES518912A0 ES518912A0 (es) | 1984-03-16 |
| ES8403489A1 true ES8403489A1 (es) | 1984-03-16 |
Family
ID=27502592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518912A Expired ES8403489A1 (es) | 1982-01-11 | 1983-01-11 | Un procedimiento para la preparacion de derivados del acido penicilanico. |
| ES525238A Granted ES525238A0 (es) | 1982-01-11 | 1983-08-30 | Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES525238A Granted ES525238A0 (es) | 1982-01-11 | 1983-08-30 | Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0084925B1 (enExample) |
| JP (1) | JPH0689005B2 (enExample) |
| AU (1) | AU538468B2 (enExample) |
| BG (1) | BG42676A3 (enExample) |
| CA (1) | CA1190921A (enExample) |
| DD (2) | DD218365A5 (enExample) |
| DE (1) | DE3362826D1 (enExample) |
| DK (1) | DK166883B1 (enExample) |
| ES (2) | ES8403489A1 (enExample) |
| FI (1) | FI79112C (enExample) |
| GR (1) | GR77152B (enExample) |
| HU (1) | HU189211B (enExample) |
| IE (1) | IE54390B1 (enExample) |
| IL (1) | IL67647A (enExample) |
| NO (6) | NO830046L (enExample) |
| NZ (1) | NZ202982A (enExample) |
| PL (1) | PL142315B1 (enExample) |
| PT (1) | PT76077B (enExample) |
| RO (2) | RO87705A (enExample) |
| YU (1) | YU43646B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4499017A (en) * | 1983-06-06 | 1985-02-12 | Pfizer Inc. | Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives |
| US4502990A (en) * | 1983-06-06 | 1985-03-05 | Pfizer Inc. | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof |
| JPS60239489A (ja) * | 1984-05-15 | 1985-11-28 | Meiji Seika Kaisha Ltd | ６−エピペニシリンスルホン化合物及びその製造方法 |
| GB2206579B (en) * | 1987-07-10 | 1991-05-29 | Erba Farmitalia | 6a and 6b-(substituted methyl)-penicillanic acid derivatives |
| US8415339B2 (en) * | 2007-05-21 | 2013-04-09 | Hans Rudolf Pfaendler | Bactericidal anti-MRSA active pharmaceutical composition containing carbapenems |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237051A (en) * | 1979-04-19 | 1980-12-02 | Schering Corporation | Stereospecific production of 6- or 7-carbon-substituted-β-lactams |
| DE2927004A1 (de) * | 1979-07-04 | 1981-05-27 | Bayer Ag, 5090 Leverkusen | Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
-
1983
- 1983-01-04 RO RO83113375A patent/RO87705A/ro unknown
- 1983-01-04 RO RO109609A patent/RO84910B/ro unknown
- 1983-01-05 DE DE8383300042T patent/DE3362826D1/de not_active Expired
- 1983-01-05 EP EP83300042A patent/EP0084925B1/en not_active Expired
- 1983-01-07 GR GR70215A patent/GR77152B/el unknown
- 1983-01-07 NO NO830046A patent/NO830046L/no unknown
- 1983-01-10 BG BG059284A patent/BG42676A3/xx unknown
- 1983-01-10 FI FI830081A patent/FI79112C/fi not_active IP Right Cessation
- 1983-01-10 YU YU44/83A patent/YU43646B/xx unknown
- 1983-01-10 CA CA000419181A patent/CA1190921A/en not_active Expired
- 1983-01-10 AU AU10232/83A patent/AU538468B2/en not_active Ceased
- 1983-01-10 PT PT76077A patent/PT76077B/pt not_active IP Right Cessation
- 1983-01-10 IE IE42/83A patent/IE54390B1/en not_active IP Right Cessation
- 1983-01-10 DK DK007483A patent/DK166883B1/da active
- 1983-01-10 HU HU8370A patent/HU189211B/hu not_active IP Right Cessation
- 1983-01-10 IL IL67647A patent/IL67647A/xx not_active IP Right Cessation
- 1983-01-10 NZ NZ202982A patent/NZ202982A/en unknown
- 1983-01-11 DD DD83262053A patent/DD218365A5/de not_active IP Right Cessation
- 1983-01-11 PL PL1983240108A patent/PL142315B1/pl unknown
- 1983-01-11 JP JP58002768A patent/JPH0689005B2/ja not_active Expired - Lifetime
- 1983-01-11 ES ES518912A patent/ES8403489A1/es not_active Expired
- 1983-01-11 DD DD83247166A patent/DD209462A5/de not_active IP Right Cessation
- 1983-08-30 ES ES525238A patent/ES525238A0/es active Granted
- 1983-09-22 NO NO833415A patent/NO833415L/no unknown
- 1983-09-22 NO NO833416A patent/NO833416L/no unknown
-
1984
- 1984-03-20 NO NO841070A patent/NO841070L/no unknown
- 1984-03-20 NO NO841069A patent/NO841069L/no unknown
- 1984-03-20 NO NO841068A patent/NO841068L/no unknown
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