ES8403479A1 - Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol. - Google Patents

Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.

Info

Publication number
ES8403479A1
ES8403479A1 ES523269A ES523269A ES8403479A1 ES 8403479 A1 ES8403479 A1 ES 8403479A1 ES 523269 A ES523269 A ES 523269A ES 523269 A ES523269 A ES 523269A ES 8403479 A1 ES8403479 A1 ES 8403479A1
Authority
ES
Spain
Prior art keywords
radical
compounds
lower alkyl
hydrogen atom
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523269A
Other languages
English (en)
Other versions
ES523269A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Publication of ES523269A0 publication Critical patent/ES523269A0/es
Publication of ES8403479A1 publication Critical patent/ES8403479A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 1-FENIL-2-AMINOCARBONILINDOL Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE Z Y R1-R9 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1-R7 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I) Y U ES HIDROGENO O UN RADICAL DE FORMULA (III), DONDE N VALE 1-3, CON UN COMPUESTO DE FORMULA R8NUKR9, EN LA QUE R8 Y R9 SON LOS MISMOS QUE EN LA FORMULA (I), Y UK ES UN RADICAL DE FORMULA (III) SI U ES HIDROGENO O UK ES HIDROGENO CUANDO U ES UN RADICALDE FORMULA (III). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE A UNA TEMPERATURA ENTRE LA AMBIENTE Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TRASTORNOS DEL RITMO CARDIACO.
ES523269A 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol. Expired ES8403479A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813131527 DE3131527A1 (de) 1981-08-08 1981-08-08 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES523269A0 ES523269A0 (es) 1984-03-16
ES8403479A1 true ES8403479A1 (es) 1984-03-16

Family

ID=6138966

Family Applications (4)

Application Number Title Priority Date Filing Date
ES514816A Expired ES8400403A1 (es) 1981-08-08 1982-08-06 "procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol".
ES523268A Expired ES8404854A1 (es) 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.
ES523267A Expired ES8403478A1 (es) 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.
ES523269A Expired ES8403479A1 (es) 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES514816A Expired ES8400403A1 (es) 1981-08-08 1982-08-06 "procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol".
ES523268A Expired ES8404854A1 (es) 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.
ES523267A Expired ES8403478A1 (es) 1981-08-08 1983-06-15 Procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol.

Country Status (21)

Country Link
US (2) US4803198A (es)
EP (1) EP0071935B1 (es)
JP (1) JPS58159459A (es)
AT (1) ATE16478T1 (es)
AU (1) AU554976B2 (es)
CA (1) CA1189859A (es)
DD (1) DD202542A5 (es)
DE (2) DE3131527A1 (es)
DK (1) DK156569B (es)
ES (4) ES8400403A1 (es)
FI (1) FI76073C (es)
GR (1) GR76804B (es)
HU (1) HU186962B (es)
IE (1) IE53646B1 (es)
IL (1) IL66485A (es)
NO (1) NO156526C (es)
NZ (1) NZ201514A (es)
PH (1) PH18886A (es)
PT (1) PT75352B (es)
SU (2) SU1195903A3 (es)
ZA (1) ZA825667B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3304019A1 (de) * 1983-02-07 1984-08-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US5047402A (en) * 1988-04-13 1991-09-10 Ici Americas Inc. Cyclic amides as medicaments
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5395817A (en) * 1992-01-22 1995-03-07 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
ZA939516B (en) * 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
US5686481A (en) * 1993-12-21 1997-11-11 Smithkline Beecham Corporation Endothelin receptor antagonists
US5684032A (en) * 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
DE19532054A1 (de) * 1995-08-31 1997-03-06 Hoechst Ag Verfahren zur Herstellung von N-Carboxymethylen-4-chlor-anthranilsäure, sowie deren Dialkylestern
JP2002515904A (ja) * 1997-05-09 2002-05-28 ハー・ルンドベック・アクティーゼルスカブ セルトインドールの製造方法
EA020332B1 (ru) * 2007-08-10 2014-10-30 Х. Лундбекк А/С Аналоги гетероариламидов
EP3291813A4 (en) 2015-05-06 2019-01-02 The Regents of The University of California K-ras modulators
SG11201909570PA (en) 2017-04-20 2019-11-28 Univ California K-ras modulators

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE158089C (es) *
DE105495C (es) *
BE439918A (es) * 1939-11-29
FR869014A (fr) * 1941-01-04 1942-01-22 Telefunken Gmbh Perfectionnements aux systèmes de concentration de rayons électroniques
US3198807A (en) * 1961-07-25 1965-08-03 Substitutes carboxamide indoles and indolines
DE1720033A1 (de) * 1966-03-02 1971-05-19 Yoshitomi Pharmaceutical Neue Indolderivate und Verfahren zu ihrer Herstellung
NL133069C (es) * 1966-07-29
DE1643262C3 (de) * 1967-12-13 1975-06-26 C.H. Boehringer Sohn, 6507 Ingelheim i-Phenoxy^-hydroxy-S-alklyaminopropane, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US3634402A (en) * 1968-04-26 1972-01-11 Sumitomo Chemical Co Process for producing 1 4-benzodiazepine derivatives and their salts
FR2260332A1 (en) * 1974-02-12 1975-09-05 Delalande Sa 1-Phenyl-2-aminocarbonyl-indoles - with respiratory analeptic, antiinflammatory analgesic, vasodilator, diuretic and anti-ulcer activity
US4196143A (en) * 1974-07-01 1980-04-01 The Dow Chemical Company Substituted phenoxyalkyl quaternary ammonium compounds
US4175083A (en) * 1975-09-08 1979-11-20 Warner-Lambert Company Indolopyrones having antiallergic activity
US4059583A (en) * 1975-11-13 1977-11-22 Mcneil Laboratories, Incorporated Substituted indoles
DE2931323A1 (de) * 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh Neue n-aminoalkylindol-derivate und ihre salze
DE3304019A1 (de) * 1983-02-07 1984-08-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
PH18886A (en) 1985-10-25
SU1195903A3 (ru) 1985-11-30
JPS58159459A (ja) 1983-09-21
IE53646B1 (en) 1989-01-04
FI76073B (fi) 1988-05-31
PT75352A (en) 1982-08-01
CA1189859A (en) 1985-07-02
NZ201514A (en) 1985-09-13
DE3267429D1 (en) 1985-12-19
DD202542A5 (de) 1983-09-21
FI822722A0 (fi) 1982-08-05
IE821896L (en) 1983-02-08
PT75352B (en) 1984-08-01
ES514816A0 (es) 1983-10-16
NO156526B (no) 1987-06-29
ATE16478T1 (de) 1985-11-15
AU554976B2 (en) 1986-09-11
EP0071935A3 (en) 1983-08-17
NO156526C (no) 1987-10-07
DK352482A (da) 1983-02-09
AU8696182A (en) 1983-02-17
ZA825667B (en) 1983-06-29
EP0071935A2 (de) 1983-02-16
NO822693L (no) 1983-02-09
IL66485A0 (en) 1982-12-31
ES523269A0 (es) 1984-03-16
ES523267A0 (es) 1984-03-16
FI822722L (fi) 1983-02-09
ES523268A0 (es) 1984-05-16
GR76804B (es) 1984-09-04
US4803198A (en) 1989-02-07
DE3131527A1 (de) 1983-02-24
EP0071935B1 (de) 1985-11-13
ES8400403A1 (es) 1983-10-16
HU186962B (en) 1985-10-28
ES8404854A1 (es) 1984-05-16
FI76073C (fi) 1988-09-09
IL66485A (en) 1985-11-29
JPH0244306B2 (es) 1990-10-03
SU1223843A3 (ru) 1986-04-07
DK156569B (da) 1989-09-11
ES8403478A1 (es) 1984-03-16
US4924004A (en) 1990-05-08

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