ES8305361A1 - "procedimiento para la preparacion de ergolinas". - Google Patents
"procedimiento para la preparacion de ergolinas".Info
- Publication number
- ES8305361A1 ES8305361A1 ES515428A ES515428A ES8305361A1 ES 8305361 A1 ES8305361 A1 ES 8305361A1 ES 515428 A ES515428 A ES 515428A ES 515428 A ES515428 A ES 515428A ES 8305361 A1 ES8305361 A1 ES 8305361A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- carbon atoms
- preparation
- treating
- ergoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 125000005265 dialkylamine group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- ACKFDYCQCBEDNU-UHFFFAOYSA-J lead(2+);tetraacetate Chemical compound [Pb+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O ACKFDYCQCBEDNU-UHFFFAOYSA-J 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3135305A DE3135305C2 (de) | 1981-09-03 | 1981-09-03 | Verfahren zur Herstellung von 8-Ergolinyl-harnstoffen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8305361A1 true ES8305361A1 (es) | 1983-05-01 |
| ES515428A0 ES515428A0 (es) | 1983-05-01 |
Family
ID=6141023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515428A Granted ES515428A0 (es) | 1981-09-03 | 1982-09-01 | "procedimiento para la preparacion de ergolinas". |
Country Status (17)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3151912A1 (de) * | 1981-12-23 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
| DE3309493A1 (de) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel |
| HU195810B (en) * | 1984-12-24 | 1988-07-28 | Sandoz Ag | Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds |
| DE3915950A1 (de) * | 1989-05-12 | 1990-11-15 | Schering Ag | 8(alpha)-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel |
| US20060171795A1 (en) * | 2005-01-28 | 2006-08-03 | Cromwell Stephen D | Substantial embedment of metallic debris |
| JP2010119349A (ja) * | 2008-11-20 | 2010-06-03 | Shinichi Okamoto | 即席のパンなどの穀物粉加工食品の製造方法 |
| AU2016209490B2 (en) * | 2015-01-20 | 2020-09-03 | Xoc Pharmaceuticals, Inc. | Isoergoline compounds and uses thereof |
| CN113149982A (zh) | 2015-01-20 | 2021-07-23 | Xoc制药股份有限公司 | 麦角灵化合物及其用途 |
| WO2018223065A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021206B1 (de) * | 1979-06-13 | 1983-06-22 | Schering Aktiengesellschaft | Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel |
-
1981
- 1981-09-03 DE DE3135305A patent/DE3135305C2/de not_active Expired
-
1982
- 1982-08-03 SU SU823470940A patent/SU1272988A3/ru active
- 1982-08-17 DK DK368382A patent/DK161646C/da not_active IP Right Cessation
- 1982-08-23 AT AT82730112T patent/ATE11289T1/de not_active IP Right Cessation
- 1982-08-23 EP EP82730112A patent/EP0074921B1/en not_active Expired
- 1982-08-23 DE DE8282730112T patent/DE3261963D1/de not_active Expired
- 1982-08-30 IL IL66679A patent/IL66679A/xx unknown
- 1982-08-31 AU AU87863/82A patent/AU555576B2/en not_active Ceased
- 1982-08-31 DD DD82242909A patent/DD203544A5/de unknown
- 1982-09-01 ES ES515428A patent/ES515428A0/es active Granted
- 1982-09-01 GR GR69181A patent/GR76897B/el unknown
- 1982-09-02 HU HU822824A patent/HU186969B/hu not_active IP Right Cessation
- 1982-09-02 CA CA000410636A patent/CA1175813A/en not_active Expired
- 1982-09-03 JP JP57152871A patent/JPS5855483A/ja active Granted
- 1982-09-03 IE IE2156/82A patent/IE53437B1/en not_active IP Right Cessation
- 1982-09-03 CS CS826422A patent/CS241122B2/cs unknown
- 1982-09-03 YU YU01992/82A patent/YU199282A/xx unknown
-
1985
- 1985-12-13 US US06/808,804 patent/US4748248A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE11289T1 (de) | 1985-02-15 |
| IE53437B1 (en) | 1988-11-09 |
| IL66679A (en) | 1986-04-29 |
| DK368382A (da) | 1983-03-04 |
| DE3135305C2 (de) | 1983-07-21 |
| IL66679A0 (en) | 1982-12-31 |
| CS642282A2 (en) | 1985-07-16 |
| DK161646C (da) | 1992-01-06 |
| JPH0239511B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-09-05 |
| SU1272988A3 (ru) | 1986-11-23 |
| EP0074921A1 (en) | 1983-03-23 |
| YU199282A (en) | 1985-03-20 |
| IE822156L (en) | 1983-03-03 |
| AU555576B2 (en) | 1986-10-02 |
| ES515428A0 (es) | 1983-05-01 |
| DK161646B (da) | 1991-07-29 |
| DE3261963D1 (en) | 1985-02-28 |
| DE3135305A1 (de) | 1983-03-10 |
| HU186969B (en) | 1985-10-28 |
| JPS5855483A (ja) | 1983-04-01 |
| CA1175813A (en) | 1984-10-09 |
| AU8786382A (en) | 1983-03-10 |
| US4748248A (en) | 1988-05-31 |
| GR76897B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-09-04 |
| EP0074921B1 (en) | 1985-01-16 |
| CS241122B2 (en) | 1986-03-13 |
| DD203544A5 (de) | 1983-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU903995D0 (en) | Process for the production of phenyl-acetate derivatives of thiopyridines and intermediers of alpha-bromic-phenyl-acetic-acid | |
| ES8305361A1 (es) | "procedimiento para la preparacion de ergolinas". | |
| ES8304127A1 (es) | "procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea". | |
| ES485650A1 (es) | Procedimiento para la preparacion de 1,2,3-tiadiazol-5-il- ureas | |
| IL44086A (en) | Derivatives of 2-aminoindane their preparation and pharmaceutical compositions containing them | |
| EP0504404A4 (en) | Process for producing 3-substituted thio-3-cephem compound | |
| GB1383888A (en) | Amino ether derivatives of orthothymatic esters | |
| ZA894470B (en) | Substituted 3-aminosydnone imines,a process for their preparation and their use | |
| IE44294L (en) | 5-thiazole methane amine derivatives | |
| JPS5555160A (en) | Preparation of substituted benzamide | |
| IE42962L (en) | Phthalimidine and benzisothiazoline derivatives. | |
| ES447615A1 (es) | Un procedimiento para obtener compuesto de cefalosporina. | |
| GB1192248A (en) | A process for the preparation of Novel Diphenylamine Derivatives | |
| GB1495197A (en) | Process for preparing pyridoxin derivatives | |
| GB771151A (en) | Method for the preparation of aminoacyl-anilides | |
| IL42380A (en) | Preparation of 2-alkoxy (or alkenyloxy)-4,5-substituted aminoalkyl benzamides | |
| ES459866A1 (es) | Procedimiento para preparar derivados del indol. | |
| DE3160295D1 (en) | Process for the preparation of n-acyl amides of alpha-ketocarboxylic acids | |
| EP0246068A3 (en) | Process for the manufacture of cephalosporin derivatives | |
| GB1449524A (en) | Preparation of salicylamide derivatives | |
| GB1383408A (en) | Substituted isoindolines processes for their manufacture and preparations containing them | |
| GB1331704A (en) | Thiazole carbamates | |
| DE3368632D1 (en) | Process for the preparation of lysergic acid esters | |
| JPS57193478A (en) | Ansa-azacyclophanetriols and their preparation | |
| JPS5663973A (en) | Novel thiadiazol-5-ylthiol ester and its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970612 |