ES8304127A1 - "procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea". - Google Patents

"procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea".

Info

Publication number
ES8304127A1
ES8304127A1 ES508735A ES508735A ES8304127A1 ES 8304127 A1 ES8304127 A1 ES 8304127A1 ES 508735 A ES508735 A ES 508735A ES 508735 A ES508735 A ES 508735A ES 8304127 A1 ES8304127 A1 ES 8304127A1
Authority
ES
Spain
Prior art keywords
haloergolinyl
novel
preparation
medicinal agents
diethylurea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508735A
Other languages
English (en)
Other versions
ES508735A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8304127A1 publication Critical patent/ES8304127A1/es
Publication of ES508735A0 publication Critical patent/ES508735A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE (2-HALOGENO-ERGOLINIL)-N ,N -DIETIL-UREA, DE FORMULA GENERAL (I), EN LA CUAL R SIGNIFICA HIDROGENO, ALCOHILO CON HASTA 6 ATOMOS DE CARBONO O ALQUENILO CON HASTA 3 ATOMOS DE CARBONO; X SIGNIFICA UN ATOMO DE HALOGENO, PREFERIBLEMENTE CLORO O BROMO; Y EL RADICAL UREA EN POSICION 8 PUEDE ENCONTRARSE EN POSICION ALFA O BETA, Y LAS SALES DE ADICION CORRESPONDIENTES. CONSISTE EN HALOGENAR DIRECTAMENTE DERIVADOS DE (ERGOLINIL)-N ,N -DIETILIUREA, DE FORMULA GENERAL (II), EN DONDE R TIENE EL SIGNIFICADO YA INDICADO. LOS COMPUESTOS ASI OBTENIDOS PUEDEN TRANSFORMARSE EN SUS SALES CORRESPONDIENTES MEDIANTE LA ADICION DE LOS ACIDOS ADECUADOS. DE APLICACION PARA LA INHIBICION DE LA LACTANCIA, PARA EL TRATAMIENTO DEL PARKINSONISMO, DE PERTURBACIONES PSICOTICAS Y DE LA HIPERTENSION.
ES508735A 1981-01-14 1982-01-14 "procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea". Granted ES508735A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813101535 DE3101535A1 (de) 1981-01-14 1981-01-14 Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8304127A1 true ES8304127A1 (es) 1983-03-01
ES508735A0 ES508735A0 (es) 1983-03-01

Family

ID=6122898

Family Applications (2)

Application Number Title Priority Date Filing Date
ES508735A Granted ES508735A0 (es) 1981-01-14 1982-01-14 "procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea".
ES517919A Granted ES517919A0 (es) 1981-01-14 1982-12-03 Procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES517919A Granted ES517919A0 (es) 1981-01-14 1982-12-03 Procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea.

Country Status (17)

Country Link
US (1) US4853390A (es)
EP (1) EP0056358B1 (es)
JP (1) JPS57145875A (es)
AT (1) ATE26716T1 (es)
AU (1) AU547987B2 (es)
CA (1) CA1175043A (es)
CS (2) CS227030B2 (es)
DD (1) DD202027A5 (es)
DE (2) DE3101535A1 (es)
DK (1) DK161146C (es)
ES (2) ES508735A0 (es)
GR (1) GR75159B (es)
HU (1) HU186898B (es)
IE (1) IE52849B1 (es)
IL (1) IL64745A0 (es)
SU (1) SU1097199A3 (es)
YU (1) YU307181A (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3410218A1 (de) * 1984-03-16 1985-09-19 Schering AG, Berlin und Bergkamen, 1000 Berlin Tergurid als antihypertensivum
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
DE3522894A1 (de) * 1985-06-24 1987-01-02 Schering Ag Verwendung von tergurid als geriatrikum
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
DE3535930A1 (de) * 1985-10-04 1987-04-09 Schering Ag Neue 2-substituierte ergolinderivate
US5242678A (en) * 1986-07-10 1993-09-07 Schering Aktiengesellschaft BR*-diagnostics for monoamine receptors
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE10066158B4 (de) 2000-08-24 2007-08-09 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH573936A5 (es) * 1971-08-05 1976-03-31 Spofa Vereinigte Pharma Werke
GB1517973A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
DE2924102A1 (de) * 1979-06-13 1980-12-18 Schering Ag Neue (ergolin-yl)-n'.n'-diaethylharnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
EP0021206B1 (de) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
DE3340025C2 (de) * 1983-11-03 1986-01-09 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen

Also Published As

Publication number Publication date
US4853390A (en) 1989-08-01
DE3276114D1 (en) 1987-05-27
JPS57145875A (en) 1982-09-09
YU307181A (en) 1983-12-31
EP0056358A1 (en) 1982-07-21
SU1097199A3 (ru) 1984-06-07
CA1175043A (en) 1984-09-25
ES8307802A1 (es) 1983-08-16
DK161146C (da) 1991-11-11
ATE26716T1 (de) 1987-05-15
IE52849B1 (en) 1988-03-30
EP0056358B1 (en) 1987-04-22
AU547987B2 (en) 1985-11-14
IL64745A0 (en) 1982-03-31
DD202027A5 (de) 1983-08-24
IE820066L (en) 1982-07-14
JPH0437079B2 (es) 1992-06-18
CS227048B2 (en) 1984-04-16
CS227030B2 (en) 1984-04-16
HU186898B (en) 1985-10-28
DK13382A (da) 1982-07-15
DK161146B (da) 1991-06-03
ES517919A0 (es) 1983-08-16
ES508735A0 (es) 1983-03-01
GR75159B (es) 1984-07-13
DE3101535A1 (de) 1982-08-12
AU7929882A (en) 1982-07-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001