JPS57145875A - Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same - Google Patents

Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same

Info

Publication number
JPS57145875A
JPS57145875A JP57003503A JP350382A JPS57145875A JP S57145875 A JPS57145875 A JP S57145875A JP 57003503 A JP57003503 A JP 57003503A JP 350382 A JP350382 A JP 350382A JP S57145875 A JPS57145875 A JP S57145875A
Authority
JP
Japan
Prior art keywords
halogen
diethylurea
ergolinyl
noradrenaline
serotonin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57003503A
Other languages
English (en)
Other versions
JPH0437079B2 (ja
Inventor
Hirushiyaa Yannkuraude
Keeru Buorufugangu
Zauaa Geruharuto
Shiyunaidaa Heruberuto
Buahateru Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS57145875A publication Critical patent/JPS57145875A/ja
Publication of JPH0437079B2 publication Critical patent/JPH0437079B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP57003503A 1981-01-14 1982-01-14 Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same Granted JPS57145875A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813101535 DE3101535A1 (de) 1981-01-14 1981-01-14 Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JPS57145875A true JPS57145875A (en) 1982-09-09
JPH0437079B2 JPH0437079B2 (ja) 1992-06-18

Family

ID=6122898

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57003503A Granted JPS57145875A (en) 1981-01-14 1982-01-14 Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same

Country Status (17)

Country Link
US (1) US4853390A (ja)
EP (1) EP0056358B1 (ja)
JP (1) JPS57145875A (ja)
AT (1) ATE26716T1 (ja)
AU (1) AU547987B2 (ja)
CA (1) CA1175043A (ja)
CS (2) CS227030B2 (ja)
DD (1) DD202027A5 (ja)
DE (2) DE3101535A1 (ja)
DK (1) DK161146C (ja)
ES (2) ES8304127A1 (ja)
GR (1) GR75159B (ja)
HU (1) HU186898B (ja)
IE (1) IE52849B1 (ja)
IL (1) IL64745A0 (ja)
SU (1) SU1097199A3 (ja)
YU (1) YU307181A (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59176285A (ja) * 1983-03-14 1984-10-05 シエ−リング・アクチエンゲゼルシヤフト 新規の置換エルゴリン、その製法および該化合物を含有する、中枢神経系に対して作用を有する医薬

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3410218A1 (de) * 1984-03-16 1985-09-19 Schering AG, Berlin und Bergkamen, 1000 Berlin Tergurid als antihypertensivum
DE3413657A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergoline
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
NL8503426A (nl) * 1984-12-24 1986-07-16 Sandoz Ag 8alfa-acylamino-ergolinen, werkwijzen voor hun bereiding en farmaceutische preparaten die ze bevatten.
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
DE3522894A1 (de) * 1985-06-24 1987-01-02 Schering Ag Verwendung von tergurid als geriatrikum
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3535929A1 (de) * 1985-10-04 1987-04-09 Schering Ag 1,2-disubstituierte ergolinderivate
DE3535930A1 (de) * 1985-10-04 1987-04-09 Schering Ag Neue 2-substituierte ergolinderivate
US5242678A (en) * 1986-07-10 1993-09-07 Schering Aktiengesellschaft BR*-diagnostics for monoamine receptors
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
GB8824744D0 (en) * 1988-10-21 1988-11-30 Erba Carlo Spa Antiemesis ergoline derivatives
DE10066158B4 (de) 2000-08-24 2007-08-09 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms
GB0307377D0 (en) * 2003-03-31 2003-05-07 Merad Pharmaceuticals Ltd Ergoline derivatives
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4826799A (ja) * 1971-08-05 1973-04-09 Spofa Vereinigte Pharma Werke
JPS5278900A (en) * 1975-12-23 1977-07-02 Sandoz Ag Improvement in organic compound
JPS562982A (en) * 1979-06-13 1981-01-13 Schering Ag Novel *ergolineeyl**n**n**diethylurea derivative* its manufacture and medicine containing it and having dopamine like activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348392A (en) * 1974-07-19 1982-09-07 Sandoz Ltd. 8α-Substituted ergoline-I derivatives
GB1517972A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 6-methyl-8alpha-cyanomethylergoline i
CH615929A5 (en) * 1975-06-02 1980-02-29 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3063869D1 (en) * 1979-06-13 1983-07-28 Schering Ag (ergolin-yl)-n', n'-diethyl urea derivatives, their preparation and pharmaceutical compositions containing them
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
DE3340025C2 (de) * 1983-11-03 1986-01-09 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4826799A (ja) * 1971-08-05 1973-04-09 Spofa Vereinigte Pharma Werke
JPS5278900A (en) * 1975-12-23 1977-07-02 Sandoz Ag Improvement in organic compound
JPS562982A (en) * 1979-06-13 1981-01-13 Schering Ag Novel *ergolineeyl**n**n**diethylurea derivative* its manufacture and medicine containing it and having dopamine like activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59176285A (ja) * 1983-03-14 1984-10-05 シエ−リング・アクチエンゲゼルシヤフト 新規の置換エルゴリン、その製法および該化合物を含有する、中枢神経系に対して作用を有する医薬

Also Published As

Publication number Publication date
ES8307802A1 (es) 1983-08-16
DE3101535A1 (de) 1982-08-12
EP0056358A1 (en) 1982-07-21
AU7929882A (en) 1982-07-22
SU1097199A3 (ru) 1984-06-07
IE52849B1 (en) 1988-03-30
DK161146C (da) 1991-11-11
YU307181A (en) 1983-12-31
DE3276114D1 (en) 1987-05-27
DK13382A (da) 1982-07-15
CS227048B2 (en) 1984-04-16
EP0056358B1 (en) 1987-04-22
DD202027A5 (de) 1983-08-24
ES508735A0 (es) 1983-03-01
IL64745A0 (en) 1982-03-31
AU547987B2 (en) 1985-11-14
ES8304127A1 (es) 1983-03-01
HU186898B (en) 1985-10-28
DK161146B (da) 1991-06-03
US4853390A (en) 1989-08-01
IE820066L (en) 1982-07-14
GR75159B (ja) 1984-07-13
JPH0437079B2 (ja) 1992-06-18
ATE26716T1 (de) 1987-05-15
ES517919A0 (es) 1983-08-16
CS227030B2 (en) 1984-04-16
CA1175043A (en) 1984-09-25

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