GB1495197A - Process for preparing pyridoxin derivatives - Google Patents

Process for preparing pyridoxin derivatives

Info

Publication number
GB1495197A
GB1495197A GB46094/75A GB4609475A GB1495197A GB 1495197 A GB1495197 A GB 1495197A GB 46094/75 A GB46094/75 A GB 46094/75A GB 4609475 A GB4609475 A GB 4609475A GB 1495197 A GB1495197 A GB 1495197A
Authority
GB
United Kingdom
Prior art keywords
aminobenzoate
ethyl
amino
derivatives
propyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46094/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambeletti Espana SA
Original Assignee
Zambeletti Espana SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambeletti Espana SA filed Critical Zambeletti Espana SA
Publication of GB1495197A publication Critical patent/GB1495197A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • C07D213/66One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/672-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1495197 Pyridoxin derivatives LAMBELETTI ESPANA SA 6 Nov 1975 [6 Nov 1974] 46094/75 Heading C2V Pyridoxin derivatives have the formula where Y is n is 2 or 3 and R<SP>1</SP> and R<SP>2</SP> are alkyl or cycloalkyl radicals or R<SP>1</SP> and R<SP>2</SP> together with the nitrogen atom form a heterocyclic ring. The derivatives may be in the form of non-toxic salts with organic and inorganic acids. The derivatives are obtained by reacting basic esters of p-aminobenzoic acid with pyridoxal by elimination of water. In examples pyridoxal hydrochloride is reacted with diethyl-amino-ethyl p-aminobenzoate, with di-n-butyl-amino-propyl-p-aminobenzoate, with di-iso-propyl-amino-ethyl paminobenzoate, with diethyl-amino-propyl paminobenzoate, with di-n-butyl-amino-ethyl paminobenzoate, with pyrrolidin-ethyl p-aminobenzoate, with morpholin-ethyl p-aminobenzoate, with di-iso-butyl-amino-ethyl p-aminobenzoate, with piperidin-propyl p-aminobenzoate, with piperidin-ethyl p-aminobenzoate and with di-methyl-amino-propyl p-aminobenzoate. The derivatives are mixed with pharmaceutically acceptable carriers.
GB46094/75A 1974-11-06 1975-11-06 Process for preparing pyridoxin derivatives Expired GB1495197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES431712A ES431712A1 (en) 1974-11-06 1974-11-06 Process for preparing pyridoxin derivatives

Publications (1)

Publication Number Publication Date
GB1495197A true GB1495197A (en) 1977-12-14

Family

ID=8467910

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46094/75A Expired GB1495197A (en) 1974-11-06 1975-11-06 Process for preparing pyridoxin derivatives

Country Status (5)

Country Link
JP (1) JPS51125289A (en)
DE (1) DE2549863C3 (en)
ES (1) ES431712A1 (en)
FR (1) FR2290201A1 (en)
GB (1) GB1495197A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233304A (en) * 1978-07-31 1980-11-11 Crinos Industria Farmacobiologica S.P.A. Pyridoxine derivatives

Also Published As

Publication number Publication date
DE2549863C3 (en) 1980-01-03
DE2549863A1 (en) 1976-09-23
FR2290201A1 (en) 1976-06-04
ES431712A1 (en) 1976-11-16
DE2549863B2 (en) 1979-05-03
JPS51125289A (en) 1976-11-01

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee