ES342806A1 - A process for the preparation of Novel Diphenylamine Derivatives - Google Patents

A process for the preparation of Novel Diphenylamine Derivatives

Info

Publication number
ES342806A1
ES342806A1 ES342806A ES342806A ES342806A1 ES 342806 A1 ES342806 A1 ES 342806A1 ES 342806 A ES342806 A ES 342806A ES 342806 A ES342806 A ES 342806A ES 342806 A1 ES342806 A1 ES 342806A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
carbon atoms
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES342806A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of ES342806A1 publication Critical patent/ES342806A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Abstract

Novel compounds of Formula I wherein R 1 and R 2 , which may the same or different, each represents a hydrogen or halogen atom, or a hydroxy, alkyl or alkoxy group, and R 3 represents either a linear or branched, alkyl or alkenyl radical with 2 to 6 carbon atoms, a pyridyl radical, a phenyl or pyridyl radical substituted by one or more halogen atoms or hydroxy, amino, alkoxy or alkyl groups, or R 3 represents an alkoxy group with 1 to 6 carbon atoms, or a group of the formula -NR6R5 wherein R 5 and R 6 each represents an alkyl group with 1 to 6 carbon atoms or may, together with the nitrogen atom, form a 5-, 6- or 7- membered heterocyclic ring optionally containing a further hetero atom, whilst R 5 can also represent a hydrogen atom, whilst any primary amino groups present may optionally be acylated by aliphatic acids or derivatives of carbonic acid, and salts of these compounds, with the proviso that R 1 does not represent an alkyl group when R 3 represents an alkoxy group with 1 to 6 carbon atoms are prepared by one of the following methods (a) by reacting a compound of formula with one of the following (i) potassium cyanate or a cyanate of formula O=C=N-R 4 where R4 is C 1-6 alkyl or (ii) with an acid of formula R 3 COOH or a halide, ester, anhydride, amide or ketene derivative thereof or (iii) with a carbonic acid derivative and simultaneously or successively ammonia or an amine H-N.R6.R5 or with (iv) a compound R 7 NH-COR 3 where R 7 is H, acyl or NO 2 , (b) by reacting a compound of formula with an amine H-N.R6.R5, or (c) forming an amino containing R 3 substitutent in Formula I above by reduction of the corresponding nitro compound and in all cases optionally followed by salt formation or N-acylation of primary amine groups. The novel compounds have analgesic and antiphlongistic properties.
ES342806A 1966-07-30 1967-07-08 A process for the preparation of Novel Diphenylamine Derivatives Expired ES342806A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DED0050724 1966-07-30

Publications (1)

Publication Number Publication Date
ES342806A1 true ES342806A1 (en) 1968-08-16

Family

ID=7052866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES342806A Expired ES342806A1 (en) 1966-07-30 1967-07-08 A process for the preparation of Novel Diphenylamine Derivatives

Country Status (10)

Country Link
AT (3) AT284862B (en)
BE (1) BE702071A (en)
CH (2) CH491863A (en)
DE (1) DE1568398A1 (en)
ES (1) ES342806A1 (en)
FI (1) FI49023C (en)
FR (1) FR7585M (en)
GB (1) GB1192248A (en)
NL (1) NL6710471A (en)
SE (1) SE364952B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1962673A1 (en) * 1969-12-13 1971-06-24 Degussa Process for the preparation of new diphenylamine derivatives
FR2074630A2 (en) * 1970-01-13 1971-10-08 Degussa 4-(acyl-amino)-4'-methyl-diphenylaminesantiinflammatory
JPS61191667A (en) * 1985-02-21 1986-08-26 Tokuyama Soda Co Ltd Urea compound

Also Published As

Publication number Publication date
BE702071A (en) 1968-01-02
AT289827B (en) 1971-05-10
GB1192248A (en) 1970-05-20
FR7585M (en) 1970-01-12
SE364952B (en) 1974-03-11
DE1568398A1 (en) 1970-02-12
FI49023B (en) 1974-12-02
AT291227B (en) 1971-07-12
CH492683A (en) 1970-06-30
CH491863A (en) 1970-06-15
AT284862B (en) 1970-10-12
FI49023C (en) 1975-03-10
NL6710471A (en) 1968-01-31

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