GB1147702A - Substituted Nicotinic Acids and methods for the manufacture thereof - Google Patents

Substituted Nicotinic Acids and methods for the manufacture thereof

Info

Publication number
GB1147702A
GB1147702A GB13779/68A GB1377968A GB1147702A GB 1147702 A GB1147702 A GB 1147702A GB 13779/68 A GB13779/68 A GB 13779/68A GB 1377968 A GB1377968 A GB 1377968A GB 1147702 A GB1147702 A GB 1147702A
Authority
GB
United Kingdom
Prior art keywords
group
alkyl
formula
substituted
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13779/68A
Inventor
Margaret H Sherlock
Nathan Sperber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Priority to GB13779/68A priority Critical patent/GB1147702A/en
Publication of GB1147702A publication Critical patent/GB1147702A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

1,147,702. Substituted 2-anilinonicotinic acid derivatives. SCHERICO Ltd. 28 Feb., 1966, No. 13779/68. Divided out of 1,147,701. Heading C2C. [Also in Division A5] Novel compounds of formula wherein M is H or C 1-4 alkyl, X is Cl or Br and Y is H, Cl, Br or Cl -4 alkyl or esters thereof or hydroxamic acid salts thereof or salts with metals, ammonia or amines such as diethanolamine, are prepared by reaction of a nicotinic acid of formula and an analine derivative of formula wherein R<SP>1</SP> is H or a group which does not interfere with the reaction, and one of Q or T is an amino group optionally mono substituted by a benzyl, alkyl or acyl group, and the other is a group capable of reacting with the amine group with the elimination of hydrogen therefrom to form a nitrogen bridge between the pyridine and phenyl moieties, for example an alkoxy, alkylthio, alkoxysulphonyl, nitro or preferably halogen substituent, and optionally followed, where necessary, by removal of any substituent on the nitrogen bridge and or salt formation. Reference has been directed by the Comptroller to Specification 1,064,259.
GB13779/68A 1966-02-28 1966-02-28 Substituted Nicotinic Acids and methods for the manufacture thereof Expired GB1147702A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB13779/68A GB1147702A (en) 1966-02-28 1966-02-28 Substituted Nicotinic Acids and methods for the manufacture thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13779/68A GB1147702A (en) 1966-02-28 1966-02-28 Substituted Nicotinic Acids and methods for the manufacture thereof

Publications (1)

Publication Number Publication Date
GB1147702A true GB1147702A (en) 1969-04-02

Family

ID=1759664

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13779/68A Expired GB1147702A (en) 1966-02-28 1966-02-28 Substituted Nicotinic Acids and methods for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB1147702A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462427A1 (en) * 1979-07-27 1981-02-13 Bago Sa Labor Analgesic and antiinflammatory 2-anilino-nicotinic acid ester prodn. - by esterification of 2-halo-nicotinic acid with halomethyl pivalate or 3-halo-phthalide and reaction with substd. aniline
FR2537579A1 (en) * 1982-12-10 1984-06-15 Bago Sa Labor Process for the preparation of alkyl and aryl esters of 3'-substituted and 2',3'-disubstituted 2-anilino-3-pyridinecarboxylic acids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462427A1 (en) * 1979-07-27 1981-02-13 Bago Sa Labor Analgesic and antiinflammatory 2-anilino-nicotinic acid ester prodn. - by esterification of 2-halo-nicotinic acid with halomethyl pivalate or 3-halo-phthalide and reaction with substd. aniline
FR2537579A1 (en) * 1982-12-10 1984-06-15 Bago Sa Labor Process for the preparation of alkyl and aryl esters of 3'-substituted and 2',3'-disubstituted 2-anilino-3-pyridinecarboxylic acids

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