ES347622A1 - N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same - Google Patents

N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same

Info

Publication number
ES347622A1
ES347622A1 ES347622A ES347622A ES347622A1 ES 347622 A1 ES347622 A1 ES 347622A1 ES 347622 A ES347622 A ES 347622A ES 347622 A ES347622 A ES 347622A ES 347622 A1 ES347622 A1 ES 347622A1
Authority
ES
Spain
Prior art keywords
formula
reacting
compound
aryl
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES347622A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES347622A1 publication Critical patent/ES347622A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel N-(tert.-aminoalkyl) amide derivatives of the general Formula III wherein R 2 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl n is 2, 3 or 4 A is a thiophone radical of the formula or a phenyl radical of the formula R and R 1 are hydrogen, C 1-6 alkyl, or halogen and B is 1-aryl.4-p-perazinyl, 4-arylpiperidino, or 4 - aryl - 3,6 - dihydro - 1(2H) - pyridyl, with the proviso when B is 1 .aryl.4.piperazinyl, A may not be phenyl or substituted phenyl and the pharmaceutically acceptable acid addition salts thereof are prepared by any of the following methods: (1) Reacting a compound A-Y with an amine of the formula B-C n H 2n -(H)R 2 , where Y is a reactive moiety being an acid halide, an ester, an ahydride or an amide. (2) Reacting a compound of formula with a compound H-B, wherein X is halogen, C 1-6 alkylsulphonyloxy, or monocyclic arylsulphonyloxy. Compounds of the above general Formula III in which A is a thiophene radical may also be prepared by the following methods: (3) Reading a compound of the formula ACON(R 2 )H with a compound of the formula X-C n H 2n B (4) Reacting an acid of the formula ACOOH with N,N1-carbonyldhmidazole and treating the thus obtained ketone with an amine of the formula B-C n H 2n N(R 2 )H (5) Reacting an acid of the formula ACOOH with an amine of the formula in the presence of a carbodiimide. N - (2 - Bromoethyl) - and N - (3 - bromopropyl) - 2 - thiopheneearboxamides are obtained by reacting 2-phenoyl chloride with 2-bromoethylamine and 3-bromopropylamine respectively. N - (2 - Bromoethyl) - and N - (2 - chloroethyl) N - methyl - benzamides are prepared by reacting benzoyl chloride with 2-bromoethylamine and 2-chloroethylmethylamine respectively. Pharmaceutical compositions, suitable for oral administration and having analgesic, antiinflammatory, diuretic and anti-depressant properties, contain the above novel compounds or their non-toxic pharmaceutically acceptable acid addition salts as the active ingredient and a pharmaceutically acceptable carrier or diluent.
ES347622A 1966-11-25 1967-11-25 N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same Expired ES347622A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59683166A 1966-11-25 1966-11-25
US59681066A 1966-11-25 1966-11-25

Publications (1)

Publication Number Publication Date
ES347622A1 true ES347622A1 (en) 1969-06-01

Family

ID=27082649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES347622A Expired ES347622A1 (en) 1966-11-25 1967-11-25 N-(Tert-Aminoalkyl) Amide Derivatives and Process for Preparing the Same

Country Status (9)

Country Link
BE (1) BE707032A (en)
CH (1) CH509311A (en)
DE (1) DE1670007A1 (en)
DK (1) DK127979B (en)
ES (1) ES347622A1 (en)
FR (1) FR7590M (en)
GB (1) GB1166364A (en)
IL (1) IL28799A (en)
NL (1) NL6715434A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1009846B (en) * 1954-03-27 1957-06-06 Strautmann & Soehne O H G B Musmuehle
DE3163803D1 (en) * 1980-02-14 1984-07-05 Grigg Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
NL8005133A (en) * 1980-09-12 1982-04-01 Duphar Int Res PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION.
GB8823042D0 (en) * 1988-09-30 1988-11-09 Lilly Sa Organic compounds & their use as pharmaceuticals
GB8823040D0 (en) * 1988-09-30 1988-11-09 Lilly Sa Organic compounds & their use as pharmaceuticals
US5166157A (en) * 1989-12-20 1992-11-24 Adir Et Compagnie Naphthyl piperazines useful as 5-HT1A receptor ligands
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists

Also Published As

Publication number Publication date
CH509311A (en) 1971-06-30
FR7590M (en) 1970-01-12
NL6715434A (en) 1968-05-27
DK127979B (en) 1974-02-11
IL28799A (en) 1972-07-26
GB1166364A (en) 1969-10-08
DE1670007A1 (en) 1971-01-21
BE707032A (en) 1968-05-24

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