ES8301210A1 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents

Un procedimiento para la preparacion de un derivado del indol.

Info

Publication number
ES8301210A1
ES8301210A1 ES504693A ES504693A ES8301210A1 ES 8301210 A1 ES8301210 A1 ES 8301210A1 ES 504693 A ES504693 A ES 504693A ES 504693 A ES504693 A ES 504693A ES 8301210 A1 ES8301210 A1 ES 8301210A1
Authority
ES
Spain
Prior art keywords
formula
migraine
treatment
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504693A
Other languages
English (en)
Spanish (es)
Other versions
ES504693A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES504693A0 publication Critical patent/ES504693A0/es
Publication of ES8301210A1 publication Critical patent/ES8301210A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES504693A 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol. Expired ES8301210A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
ES504693A0 ES504693A0 (es) 1982-12-01
ES8301210A1 true ES8301210A1 (es) 1982-12-01

Family

ID=10515410

Family Applications (5)

Application Number Title Priority Date Filing Date
ES504693A Expired ES8301210A1 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513933A Granted ES513933A0 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Expired ES8500903A1 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES513933A Granted ES513933A0 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Expired ES8500903A1 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Country Status (16)

Country Link
US (1) US4650810A (en:Method)
JP (1) JPS5764669A (en:Method)
AU (1) AU548467B2 (en:Method)
BE (1) BE889929A (en:Method)
CA (1) CA1169428A (en:Method)
CH (1) CH651551A5 (en:Method)
DE (1) DE3131728A1 (en:Method)
DK (1) DK157920C (en:Method)
ES (5) ES8301210A1 (en:Method)
FR (1) FR2488607A1 (en:Method)
IE (1) IE51491B1 (en:Method)
IT (1) IT1171449B (en:Method)
NL (1) NL8103769A (en:Method)
NZ (1) NZ197996A (en:Method)
SE (1) SE454880B (en:Method)
ZA (1) ZA815540B (en:Method)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79215B (en:Method) * 1982-06-07 1984-10-22 Glaxo Group Ltd
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
DE3678805D1 (de) * 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DK0486666T3 (da) * 1990-06-07 1998-03-30 Zeneca Ltd Terapeutisk heterocykliske forbindelser
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
EP1572647B1 (en) * 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
ES2538082T3 (es) 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Método de administración terapéutica de DHE para permitir el rápido alivio de migraña mientras que se minimiza el perfil de efectos secundarios
CL2008000838A1 (es) 2007-03-23 2008-10-10 Neuraxon Inc Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios
BRPI0809542A8 (pt) 2007-03-29 2015-09-15 Asubio Pharma Co Ltd Compostos derivados de indol tendo atividade de inibição de cpla2, composição farmacêutica, e métodos de produção dos referidos compostos
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US9399053B2 (en) 2011-07-22 2016-07-26 The University Of Chicago Treatments for migraine and related disorders
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
US4650810A (en) 1987-03-17
ES8504706A1 (es) 1985-05-01
DE3131728C2 (en:Method) 1992-04-30
FR2488607A1 (fr) 1982-02-19
ES520783A0 (es) 1985-05-01
IT8149084A1 (it) 1983-02-11
ZA815540B (en) 1983-03-30
JPS5764669A (en) 1982-04-19
ES520785A0 (es) 1984-11-01
DK157920C (da) 1990-08-06
ES8402268A1 (es) 1984-01-16
CH651551A5 (fr) 1985-09-30
DK157920B (da) 1990-03-05
ES513933A0 (es) 1984-01-16
IE811830L (en) 1982-02-12
FR2488607B1 (en:Method) 1984-11-16
ES8500902A1 (es) 1984-11-01
AU7399481A (en) 1982-02-18
ES504693A0 (es) 1982-12-01
SE8104781L (sv) 1982-02-13
JPH0247462B2 (en:Method) 1990-10-19
ES8500903A1 (es) 1984-11-01
IT8149084A0 (it) 1981-08-11
BE889929A (fr) 1982-02-11
IE51491B1 (en) 1987-01-07
DK357081A (da) 1982-02-13
AU548467B2 (en) 1985-12-12
DE3131728A1 (de) 1982-03-11
ES520784A0 (es) 1984-11-01
NZ197996A (en) 1985-08-16
NL8103769A (nl) 1982-03-01
SE454880B (sv) 1988-06-06
IT1171449B (it) 1987-06-10
CA1169428A (en) 1984-06-19

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