ES8301966A1 - Procedimiento para preparar derivados de pirimidona - Google Patents

Procedimiento para preparar derivados de pirimidona

Info

Publication number
ES8301966A1
ES8301966A1 ES505898A ES505898A ES8301966A1 ES 8301966 A1 ES8301966 A1 ES 8301966A1 ES 505898 A ES505898 A ES 505898A ES 505898 A ES505898 A ES 505898A ES 8301966 A1 ES8301966 A1 ES 8301966A1
Authority
ES
Spain
Prior art keywords
derivatives
processes
preparation
pharmaceutical
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505898A
Other languages
English (en)
Other versions
ES505898A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8301966A1 publication Critical patent/ES8301966A1/es
Publication of ES505898A0 publication Critical patent/ES505898A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIMIDONA Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R SON ALQUILO C <003> O JUNTOS CON EL NITROGENO FORMAN PIRROLIDINA O PIRERIDINA; Y ES METILENO O AZUFRE Y X ES OXIGENO O METILENO, RESPECTIVAMENTE; Z ES HIDROGENO O ALQUILO C <003> ; Y R PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE UNA AMINA DE FORMULA (II) CON UNA PIRIMIDONA DE FORMULA (III), EN LAS QUE Q PUEDE SER VARIOS RADICALES; R ES R O UN DERIVADO DEL MISMO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE POLAR NO REACTIVO O EN AUSENCIA DE DISOLVENTE A TEMPERATURA ELEVADA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ULCERACION DUODENAL, GASTRICA RECURRENTE Y ESTOMAGAL Y EN ESTOFAGITIS DE REFLUJO.
ES505898A 1980-10-01 1981-09-30 Procedimiento para preparar derivados de pirimidona Granted ES505898A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8031685 1980-10-01

Publications (2)

Publication Number Publication Date
ES8301966A1 true ES8301966A1 (es) 1983-01-01
ES505898A0 ES505898A0 (es) 1983-01-01

Family

ID=10516418

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505898A Granted ES505898A0 (es) 1980-10-01 1981-09-30 Procedimiento para preparar derivados de pirimidona

Country Status (22)

Country Link
US (1) US4385058A (es)
EP (1) EP0049173B1 (es)
JP (1) JPS5791986A (es)
KR (1) KR830007630A (es)
AT (1) ATA420581A (es)
AU (1) AU547215B2 (es)
CA (1) CA1170261A (es)
DD (1) DD200469A5 (es)
DE (1) DE3171234D1 (es)
DK (1) DK435681A (es)
ES (1) ES505898A0 (es)
FI (1) FI813054L (es)
GR (1) GR75783B (es)
IL (1) IL63913A0 (es)
NO (1) NO813326L (es)
PH (2) PH17948A (es)
PL (1) PL233256A1 (es)
PT (1) PT73691B (es)
RO (1) RO82214A (es)
YU (1) YU236881A (es)
ZA (1) ZA816794B (es)
ZW (1) ZW21281A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT74865B (en) * 1981-05-27 1983-12-07 Smithkline Beckman Corp Process of preparing a 2-(pyridylbutylamino)-pyrimidone and of its pharmaceutically acceptable salts
ZA823149B (en) * 1981-05-27 1983-03-30 Smithkline Beckman Corp Chemical process
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
DE3366369D1 (en) * 1982-03-17 1986-10-30 Smith Kline French Lab Pyridine derivatives
EP0102157B1 (en) * 1982-07-30 1986-09-03 Smith Kline & French Laboratories Limited Amino pyrimidinones and their preparation
PT77287B (en) * 1982-10-01 1986-02-04 Smith Kline French Lab Compound
US4466970A (en) * 1982-10-02 1984-08-21 Smith Kline & French Laboratories Limited Dioxocyclobutene compounds
PT77623B (en) * 1982-11-25 1986-03-19 Smith Kline French Lab Process for the preparation of a small class of histamine h2-antagonists
JO1274B1 (en) * 1982-12-03 1985-04-20 سيدني ساخ جورج Pyridine derivatives
DE3374313D1 (de) * 1982-12-23 1987-12-10 Smith Kline French Lab Aminopyrimidinone derivatives as histamine h1-antagonists
EP0113572B1 (en) * 1982-12-23 1988-02-03 Smith Kline & French Laboratories Limited Pyridine derivatives
GB8311443D0 (en) * 1983-04-27 1983-06-02 Smith Kline French Lab Chemical compounds
GB8318638D0 (en) * 1983-07-09 1983-08-10 Smith Kline French Lab Chemical compounds
GB8319874D0 (en) * 1983-07-23 1983-08-24 Smith Kline French Lab Compounds
GB8320505D0 (en) * 1983-07-29 1983-09-01 Smith Kline French Lab Chemical compounds
US4772704A (en) * 1983-09-21 1988-09-20 Bristol-Myers Company 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity
GB8332091D0 (en) * 1983-12-01 1984-01-11 Smith Kline French Lab Chemical compounds
GB8421427D0 (en) * 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
CA1275097A (en) * 1984-10-02 1990-10-09 Fujio Nohara Pyridyloxy derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
US4931452A (en) * 1987-11-10 1990-06-05 The Dow Chemical Company N-cyanomethyl-2-pyridinone insecticides
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
US4145546A (en) * 1975-10-02 1979-03-20 Smith Kline & French Laboratories Limited 4-Pyrimidone compounds
IN146736B (es) * 1975-10-02 1979-08-25 Smith Kline French Lab
US4218452A (en) * 1975-10-02 1980-08-19 Smith Kline & French Laboratories Limited Substituted 4-pyrimidone compounds, compositions and methods of use
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4250316A (en) * 1978-11-24 1981-02-10 Bristol-Myers Company Pyridyl guanidine anti-ulcer agents
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives

Also Published As

Publication number Publication date
ATA420581A (de) 1985-03-15
PH17948A (en) 1985-02-11
ZW21281A1 (en) 1981-11-18
FI813054L (fi) 1982-04-02
JPS6328069B2 (es) 1988-06-07
US4385058A (en) 1983-05-24
PH17950A (en) 1985-02-11
YU236881A (en) 1984-02-29
PT73691A (en) 1981-10-01
ES505898A0 (es) 1983-01-01
EP0049173A3 (en) 1982-06-30
PT73691B (en) 1982-12-10
AU7595181A (en) 1982-04-08
DK435681A (da) 1982-04-02
RO82214B (ro) 1983-06-30
NO813326L (no) 1982-04-02
EP0049173B1 (en) 1985-07-03
RO82214A (ro) 1983-07-07
GR75783B (es) 1984-08-02
PL233256A1 (es) 1982-11-08
DD200469A5 (de) 1983-05-04
CA1170261A (en) 1984-07-03
IL63913A0 (en) 1981-12-31
EP0049173A2 (en) 1982-04-07
AU547215B2 (en) 1985-10-10
KR830007630A (ko) 1983-11-04
ZA816794B (en) 1982-10-27
DE3171234D1 (en) 1985-08-08
JPS5791986A (en) 1982-06-08

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