ES8703830A1 - Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. - Google Patents

Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral.

Info

Publication number
ES8703830A1
ES8703830A1 ES545170A ES545170A ES8703830A1 ES 8703830 A1 ES8703830 A1 ES 8703830A1 ES 545170 A ES545170 A ES 545170A ES 545170 A ES545170 A ES 545170A ES 8703830 A1 ES8703830 A1 ES 8703830A1
Authority
ES
Spain
Prior art keywords
amino acid
compositions containing
acid derivatives
tumor activity
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545170A
Other languages
English (en)
Other versions
ES545170A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8703830A1 publication Critical patent/ES8703830A1/es
Publication of ES545170A0 publication Critical patent/ES545170A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE AMIDAS DE AMINOACIDO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA R1XOH, O UN DERIVADO REACTIVO DEL MISMO CON UN COMPUESTO DE FORMULA (II), PARA OBTENER AMIDAS DE AMINOACIDO DE FORMULA (I), DONDE R1 ES UN GRUPO BENCILO, UN GRUPO FENILO, O UN GRUPO FENILO QUE TIENE 1 O 2 SUSTITUYENTES DEL GRUPO FORMADO POR ALQUILO C 1 A 4 Y OTROS; X ES UN GRUPO CARBONILO O SULFONILO; R2 ES UN ATOMO DE HIDROGENO; R3 Y R4 SON UN GRUPO FORMADO POR ATOMOS DE HIDROGENO Y GRUPO METILO; Y ES UN GRUPO ALQUILENO C 1 A 5 O UN GRUPO ALQUILENO C 1 A 5 CON SUSTITUYENTES; Y R5 ES UN GRUPO ALQUILO C 1 A 4 Y OTROS. TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES545170A 1984-07-13 1985-07-12 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. Expired ES8703830A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59145731A JPH0662529B2 (ja) 1984-07-13 1984-07-13 アミノ酸誘導体

Publications (2)

Publication Number Publication Date
ES8703830A1 true ES8703830A1 (es) 1987-03-01
ES545170A0 ES545170A0 (es) 1987-03-01

Family

ID=15391835

Family Applications (3)

Application Number Title Priority Date Filing Date
ES545170A Expired ES8703830A1 (es) 1984-07-13 1985-07-12 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral.
ES557196A Expired ES8801185A1 (es) 1984-07-13 1986-11-13 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral
ES557197A Expired ES8801186A1 (es) 1984-07-13 1986-11-13 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557196A Expired ES8801185A1 (es) 1984-07-13 1986-11-13 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral
ES557197A Expired ES8801186A1 (es) 1984-07-13 1986-11-13 Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral

Country Status (7)

Country Link
US (1) US4904680A (es)
EP (1) EP0173441B1 (es)
JP (1) JPH0662529B2 (es)
AT (1) ATE49749T1 (es)
CA (1) CA1283917C (es)
DE (1) DE3575554D1 (es)
ES (3) ES8703830A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途
FR2646847B1 (fr) * 1989-05-12 1991-07-12 Rhone Poulenc Sante N-phenyl amides, leurs procedes de preparation et les medicaments les contenant
JPH0524090U (ja) * 1991-09-20 1993-03-30 仲秋 張 ジグソーパズル
HU211995B (en) * 1992-06-30 1996-01-29 Gyogyszerkutato Intezet Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them
US5854250A (en) * 1995-10-11 1998-12-29 Gyogyszerkutato Intezet Kft N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process of preparing same
KR20010012321A (ko) * 1997-05-07 2001-02-15 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 신규의 시스테인 유도체, 이의 제조 방법 및 이를 함유한약제
JP4524039B2 (ja) * 1997-12-18 2010-08-11 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｓｒｃファミリーｓｈ２ドメインインヒビターとしてのピリドン
US7427496B2 (en) * 1999-06-25 2008-09-23 The Regents Of The University Of Colorado Anti-cancer compounds
CA2401749A1 (en) 2000-03-23 2001-09-27 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
CA2410972A1 (en) 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
ZA200406763B (en) * 2002-03-28 2005-09-30 Applied Research Systems Thiazolidine carboxamide derivatives as modulatorsof the prostaglandin F receptor.
DE102005028492A1 (de) * 2005-06-20 2006-12-28 Basf Ag Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen
MX2020002696A (es) 2017-09-13 2020-09-25 Amgen Inc Compuestos de bisamida que activan el sarcomero y sus usos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE213641C (es) *
DE1236519B (de) * 1959-09-19 1967-03-16 Nippon Shinyaku Co Ltd Verfahren zum Herstellen eines analgetisch wirksamen Salicylsaeure-Derivates
DE1793613A1 (de) * 1966-05-13 1971-09-02 Francia Farma gamma-Orthohydroxybenzamidbutyramid
CH513123A (de) * 1967-09-25 1971-09-30 Bayer Ag Verfahren zur Herstellung von N-Acyl-a-aminosäureamiden bzw. -peptiden
IE33790B1 (en) * 1968-06-04 1974-10-30 Beecham Group Ltd Derivatives of n-acylaminoacid amides
DE2139641A1 (de) * 1971-08-07 1973-02-15 Bayer Ag 2-(p-chlorbenzoylamino)-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
EP0059536B1 (en) * 1981-03-04 1987-04-22 Imperial Chemical Industries Plc Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them

Also Published As

Publication number Publication date
EP0173441A1 (en) 1986-03-05
ES557197A0 (es) 1988-01-01
ES557196A0 (es) 1988-01-01
ES8801186A1 (es) 1988-01-01
JPH0662529B2 (ja) 1994-08-17
DE3575554D1 (de) 1990-03-01
ATE49749T1 (de) 1990-02-15
CA1283917C (en) 1991-05-07
ES545170A0 (es) 1987-03-01
JPS6124550A (ja) 1986-02-03
ES8801185A1 (es) 1988-01-01
US4904680A (en) 1990-02-27
EP0173441B1 (en) 1990-01-24

Similar Documents

Publication Publication Date Title
ATE60761T1 (de) Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
NZ215008A (en) Heterocyclic compounds and herbicidal compositions
CS960586A2 (en) Insekticidni a akaricidni prostredek a zpusob vyroby ucinnych latek
CA2143636A1 (en) Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants
ES8801186A1 (es) Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
BE905109A (fr) Derives de distamycine et leur procede de fabrication.
ES8605511A1 (es) Un procedimiento para la preparacion de derivados de tiazol,2, 4, disustituidos.
GB1535770A (en) Pharmaceutical compositions
ES468173A1 (es) Un procedimiento para la preparacion de derivados de morfina
EP0321968A3 (en) Compounds active on the cardiovascular system
ATE71944T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ES468170A1 (es) Un procedimiento para la preparacion de un nuevo derivado demorfina
EP0333000A3 (en) Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
ES8407322A1 (es) Procedimiento para la preparacion de 7 -aciltio-15,16-metilen-3-oxo-17 -pregna-1,4-dien-21,17-carbolactonas
DE3668888D1 (de) Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung.
ZA925782B (en) N-(isoquinolin-5-ylsulphonyl) azacycloalkanes, process for the preparation thereof and pharmaceutical compositions containing them.
GB1437896A (en) Substituted thiazole-2-carboxylic amides and process for the preparation thereof
AU561132B2 (en) Biologically active heptapeptides
IL77051A (en) Crystalline form of the monoethanolamine salt of n-(2-pyridyl)-2-methyl-4-hydroxy-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide and pharmaceutical compositions containing it
DE69007356D1 (de) Zyklisches Tetrapeptid und Verfahren zu dessen Herstellung.
GB8515212D0 (en) Thiazolidine derivatives
DE3663664D1 (en) Compounds having antiplatelet aggregation activity, a process for the preparation thereof and pharmaceutical compositions containing them
EP0332999A3 (en) Peptides with inhibitory activity of enzymatic systems, process for their preparation and pharmaceutical compositions containing them
EP0321967A3 (en) Compounds active on the cardiovascular system

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612