ES8801185A1 - Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral - Google Patents
Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoralInfo
- Publication number
- ES8801185A1 ES8801185A1 ES557196A ES557196A ES8801185A1 ES 8801185 A1 ES8801185 A1 ES 8801185A1 ES 557196 A ES557196 A ES 557196A ES 557196 A ES557196 A ES 557196A ES 8801185 A1 ES8801185 A1 ES 8801185A1
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- compositions containing
- acid derivatives
- tumor activity
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE AMIDAS DE AMINOACIDO, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 REPRESENTA UN GRUPO BENCILO, UN GRUPO FENILO O UN GRUPO FENILO QUE TIENE 1 O 2 SUSTITUYENTES SELECCIONADOS ENTRE HIDROXI, CARBOXI, NITRO, TRIFLUORMETILO O AMINO; R2 REPRESENTA UN ATOMO DE HIDROGENO; Y REPRESENTA UN GRUPO ALQUILENO C1-5; Y X REPRESENTA UN GRUPO CARBONILO O SULFONILO, CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE R3 Y R4 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO METILO; Y R5REPRESENTA UN GRUPO ALQUILO C1-4, EN PRESENCIA DE UN AGENTE CONDENSANTE. DE APLICACION EN MEDICINA POR SU ACTIVIDAD ANTITUMORAL E INMUNORREGULADORA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59145731A JPH0662529B2 (ja) | 1984-07-13 | 1984-07-13 | アミノ酸誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8801185A1 true ES8801185A1 (es) | 1988-01-01 |
ES557196A0 ES557196A0 (es) | 1988-01-01 |
Family
ID=15391835
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545170A Expired ES8703830A1 (es) | 1984-07-13 | 1985-07-12 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. |
ES557196A Expired ES8801185A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
ES557197A Expired ES8801186A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545170A Expired ES8703830A1 (es) | 1984-07-13 | 1985-07-12 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557197A Expired ES8801186A1 (es) | 1984-07-13 | 1986-11-13 | Un procedimiento para la preparacion de amidas de aminoacido con actividad antitumoral |
Country Status (7)
Country | Link |
---|---|
US (1) | US4904680A (es) |
EP (1) | EP0173441B1 (es) |
JP (1) | JPH0662529B2 (es) |
AT (1) | ATE49749T1 (es) |
CA (1) | CA1283917C (es) |
DE (1) | DE3575554D1 (es) |
ES (3) | ES8703830A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
FR2646847B1 (fr) * | 1989-05-12 | 1991-07-12 | Rhone Poulenc Sante | N-phenyl amides, leurs procedes de preparation et les medicaments les contenant |
JPH0524090U (ja) * | 1991-09-20 | 1993-03-30 | 仲秋 張 | ジグソーパズル |
HU211995B (en) * | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
US5854250A (en) * | 1995-10-11 | 1998-12-29 | Gyogyszerkutato Intezet Kft | N-benzoylamino acid derivatives, pharmaceutical compositions containing them and process of preparing same |
TR199903120T2 (xx) * | 1997-05-07 | 2000-05-22 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften | Yeni sistein türevleri, bunların üretimi için işlemler ve bunları ihtiva eden farmasötik maddeler. |
JP4524039B2 (ja) * | 1997-12-18 | 2010-08-11 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Srcファミリーsh2ドメインインヒビターとしてのピリドン |
US7427496B2 (en) * | 1999-06-25 | 2008-09-23 | The Regents Of The University Of Colorado | Anti-cancer compounds |
AU2001252958A1 (en) | 2000-03-23 | 2001-10-03 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
ATE302751T1 (de) | 2000-06-30 | 2005-09-15 | Elan Pharm Inc | Verbindungen zur behandlung der alzheimerischen krankheit |
MXPA04009374A (es) * | 2002-03-28 | 2005-01-25 | Applied Research Systems | Derivados de tiazolidincarboxamida como moduladores del receptor de prostaglandina. |
DE102005028492A1 (de) * | 2005-06-20 | 2006-12-28 | Basf Ag | Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen |
AU2018332887B2 (en) * | 2017-09-13 | 2022-12-08 | Amgen Inc. | Bisamide sarcomere activating compounds and uses thereof |
CN117945945A (zh) * | 2022-10-28 | 2024-04-30 | 浙江友宁生物医药科技有限公司 | 一种gpr139受体激动剂、其制备方法及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE213641C (es) * | ||||
DE1236519B (de) * | 1959-09-19 | 1967-03-16 | Nippon Shinyaku Co Ltd | Verfahren zum Herstellen eines analgetisch wirksamen Salicylsaeure-Derivates |
DE1793613A1 (de) * | 1966-05-13 | 1971-09-02 | Francia Farma | gamma-Orthohydroxybenzamidbutyramid |
CH513123A (de) * | 1967-09-25 | 1971-09-30 | Bayer Ag | Verfahren zur Herstellung von N-Acyl-a-aminosäureamiden bzw. -peptiden |
IE33790B1 (en) * | 1968-06-04 | 1974-10-30 | Beecham Group Ltd | Derivatives of n-acylaminoacid amides |
DE2139641A1 (de) * | 1971-08-07 | 1973-02-15 | Bayer Ag | 2-(p-chlorbenzoylamino)-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
AU518147B2 (en) * | 1976-12-03 | 1981-09-17 | E.R. Squibb & Sons, Inc. | Derivatives of thiazolidine, thiazine and morpholine carboxylic acids |
GB2094786B (en) * | 1981-03-04 | 1985-09-11 | Ici Plc | Herbicidal and fungicidal amide derivatives |
-
1984
- 1984-07-13 JP JP59145731A patent/JPH0662529B2/ja not_active Expired - Fee Related
-
1985
- 1985-07-12 ES ES545170A patent/ES8703830A1/es not_active Expired
- 1985-07-15 CA CA000486792A patent/CA1283917C/en not_active Expired - Fee Related
- 1985-07-15 AT AT85305052T patent/ATE49749T1/de not_active IP Right Cessation
- 1985-07-15 DE DE8585305052T patent/DE3575554D1/de not_active Expired - Fee Related
- 1985-07-15 EP EP85305052A patent/EP0173441B1/en not_active Expired - Lifetime
-
1986
- 1986-11-13 ES ES557196A patent/ES8801185A1/es not_active Expired
- 1986-11-13 ES ES557197A patent/ES8801186A1/es not_active Expired
-
1988
- 1988-01-22 US US07/146,955 patent/US4904680A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0173441B1 (en) | 1990-01-24 |
JPH0662529B2 (ja) | 1994-08-17 |
DE3575554D1 (de) | 1990-03-01 |
ES557197A0 (es) | 1988-01-01 |
ES557196A0 (es) | 1988-01-01 |
EP0173441A1 (en) | 1986-03-05 |
ATE49749T1 (de) | 1990-02-15 |
JPS6124550A (ja) | 1986-02-03 |
US4904680A (en) | 1990-02-27 |
CA1283917C (en) | 1991-05-07 |
ES8801186A1 (es) | 1988-01-01 |
ES8703830A1 (es) | 1987-03-01 |
ES545170A0 (es) | 1987-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |