ES8205194A1 - Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido - Google Patents

Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido

Info

Publication number
ES8205194A1
ES8205194A1 ES498871A ES498871A ES8205194A1 ES 8205194 A1 ES8205194 A1 ES 8205194A1 ES 498871 A ES498871 A ES 498871A ES 498871 A ES498871 A ES 498871A ES 8205194 A1 ES8205194 A1 ES 8205194A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
peptide derivatives
ergot peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498871A
Other languages
English (en)
Other versions
ES498871A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH547779A external-priority patent/CH643560A5/de
Priority claimed from CH547679A external-priority patent/CH642082A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8205194A1 publication Critical patent/ES8205194A1/es
Publication of ES498871A0 publication Critical patent/ES498871A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN ALCALOIDE 2-METIL-8(R) O (S) ERGOT-PEPTIDO, DE FORMULA (I), EN LA QUE R1 ES ALQUILO C1-4, R2 ES ALQUILO C1-6 O BENCILO, R3 Y R4 SON HIDROGENO O ALQUILO C1-4, R5 ES HIDROGENO O BROMO, R6 ES HIDROGENO O METOXI Y R7 ES HIDROGENO, O R6 Y R7 FORMAN UN DOBLE ENLACE. CONSISTE EN LA REACCION DE REDUCCION DE UN ALCALOIDE ERGOT-PEPTIDO ADECUADO, SUSTITUIDO EN LA POSICION 2 CON UN RADICAL DITIOMETINO O TIOMETILENO, CAPAZ DE SER REDUCIDO A UN RADICAL METILO. LA REACCION SE LLEVA A CABO POR REDUCCION CATALITICA, EN PRESENCIA DE NIQUEL RANEY, EN DISOLUCION ORGANICA, A TEMPERATURA AMBIENTE O LIGERAMENTE SUPERIOR. TAMBIEN SE PUEDE REDUCIR CON HIDRUROS METALICO
ES498871A 1979-06-12 1981-01-28 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido Granted ES498871A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH547979 1979-06-12
CH547879 1979-06-12
CH547779A CH643560A5 (en) 1979-06-12 1979-06-12 Ergopeptin derivatives, their preparation and use
CH547679A CH642082A5 (en) 1979-06-12 1979-06-12 Ergopeptin derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
ES8205194A1 true ES8205194A1 (es) 1982-06-01
ES498871A0 ES498871A0 (es) 1982-06-01

Family

ID=27428898

Family Applications (3)

Application Number Title Priority Date Filing Date
ES492332A Expired ES8105331A1 (es) 1979-06-12 1980-06-11 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido
ES498871A Granted ES498871A0 (es) 1979-06-12 1981-01-28 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido
ES498872A Expired ES8205195A1 (es) 1979-06-12 1981-01-28 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES492332A Expired ES8105331A1 (es) 1979-06-12 1980-06-11 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES498872A Expired ES8205195A1 (es) 1979-06-12 1981-01-28 Procedimiento para preparar un alcaloide 2-metil-8(r) o (s) ergotpeptido

Country Status (24)

Country Link
US (1) US4547500A (es)
AR (1) AR231142A1 (es)
AU (1) AU545645B2 (es)
CA (1) CA1169856A (es)
CY (1) CY1331A (es)
DE (1) DE3020895A1 (es)
DK (1) DK250580A (es)
ES (3) ES8105331A1 (es)
FI (1) FI70222C (es)
FR (1) FR2458552A1 (es)
GB (2) GB2053908B (es)
HK (1) HK40286A (es)
HU (1) HU184299B (es)
IE (1) IE49610B1 (es)
IL (1) IL60287A (es)
IT (1) IT1146938B (es)
KE (1) KE3622A (es)
MA (1) MA18872A1 (es)
NL (1) NL8003318A (es)
NO (1) NO154635C (es)
NZ (1) NZ193992A (es)
PH (1) PH19334A (es)
PT (1) PT71374B (es)
SE (2) SE445645B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU571927B2 (en) * 1979-06-12 1988-04-28 Sandoz Ltd. A 2-methyl ergot peptide alkaloid
CH656533A5 (de) * 1982-12-10 1986-07-15 Sandoz Ag Therapeutisches praeparat enthaltend hydrierte ergotalkaloide und niedermolekulares heparin.
GB8426922D0 (en) * 1984-10-24 1984-11-28 Sandoz Ltd Galenic formulation
CA2838991A1 (en) 2011-06-23 2012-12-27 Map Pharmaceuticals, Inc. Novel fluoroergoline analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
CA990287A (en) * 1972-09-26 1976-06-01 Sandoz Patents Limited 13-bromo-lysergic acid compounds
CH588485A5 (en) * 1973-10-12 1977-06-15 Sandoz Ag (17)-Ergolene derivs. prepn. - from lysergic acid (6)-(N)-oxide derivs.
CH587858A5 (es) * 1973-11-28 1977-05-13 Sandoz Ag
CH610330A5 (en) * 1974-09-27 1979-04-12 Sandoz Ag Process for the preparation of novel ergopeptins
CH601321A5 (es) * 1975-01-06 1978-07-14 Sandoz Ag
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives

Also Published As

Publication number Publication date
IE49610B1 (en) 1985-10-30
IL60287A0 (en) 1980-09-16
SE457260B (sv) 1988-12-12
IE801206L (en) 1980-12-12
IT8048924A0 (it) 1980-06-10
FI70222B (fi) 1986-02-28
AR231142A1 (es) 1984-09-28
CA1169856A (en) 1984-06-26
PT71374A (en) 1980-07-01
HU184299B (en) 1984-07-30
NZ193992A (en) 1982-12-21
DK250580A (da) 1980-12-13
MA18872A1 (fr) 1980-12-31
NO154635B (no) 1986-08-11
FI70222C (fi) 1986-09-15
SE8500490D0 (sv) 1985-02-04
SE445645B (sv) 1986-07-07
SE8500490L (sv) 1985-02-04
KE3622A (en) 1986-05-16
SE8004306L (sv) 1980-12-13
NL8003318A (nl) 1980-12-16
IL60287A (en) 1986-03-31
FR2458552A1 (fr) 1981-01-02
AU5923380A (en) 1980-12-18
GB2053908B (en) 1983-11-30
ES498872A0 (es) 1982-06-01
ES492332A0 (es) 1981-05-16
ES498871A0 (es) 1982-06-01
GB2121030A (en) 1983-12-14
PT71374B (en) 1981-06-25
ES8205195A1 (es) 1982-06-01
ES8105331A1 (es) 1981-05-16
GB2053908A (en) 1981-02-11
FR2458552B1 (es) 1983-08-19
AU545645B2 (en) 1985-07-25
HK40286A (en) 1986-06-06
IT1146938B (it) 1986-11-19
US4547500A (en) 1985-10-15
NO801724L (no) 1980-12-15
NO154635C (no) 1986-11-19
PH19334A (en) 1986-03-21
CY1331A (en) 1986-06-27
DE3020895A1 (de) 1980-12-18
GB2121030B (en) 1984-05-23
FI801810A (fi) 1980-12-13

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