RO91197B - Procedeu pentru prepararea unor derivati de piridazinamina - Google Patents

Procedeu pentru prepararea unor derivati de piridazinamina

Info

Publication number
RO91197B
RO91197B RO118137A RO11813785A RO91197B RO 91197 B RO91197 B RO 91197B RO 118137 A RO118137 A RO 118137A RO 11813785 A RO11813785 A RO 11813785A RO 91197 B RO91197 B RO 91197B
Authority
RO
Romania
Prior art keywords
preparation
pyridazinamines
preparing
compounds
pyridazinamine
Prior art date
Application number
RO118137A
Other languages
English (en)
Other versions
RO91197A (ro
Inventor
Raymond Antoine Stokbroekx
Der Aa Marcel Jozef Maria Van
Joannes Josephus Maria Willems
Marcel Gerembernus Maria Luyckx
Original Assignee
Janssen Pharmaceutica N.V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V filed Critical Janssen Pharmaceutica N.V
Publication of RO91197A publication Critical patent/RO91197A/ro
Publication of RO91197B publication Critical patent/RO91197B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Inventia se refra la un procedeu pentru prepararea unor derivati de piridazinamina cu formula generala I: (vezi formula) în care R1 este un hidrogen, halogen, 1H-imidazol-1-il, alchiloxiinferior, feniloxi, alchiloxifenil inferior, alchiltio inferior, feniltio, hidroxi, mercapto, amino, sulfinilalchil inferior, sulfonilalchil inferior cian, alchiloxicarbonil, alchilcarbonil inferior si alchil inferior: R2 si R3 sînt, fiecare independent, hidrogen si alchil inferior sau R2 si R3 combinati pot forma un radical bivalent cu formula -CH=CH-=CH; A este un radical bivalent cu formula (vezi formula) în care pot fi înlocuiti prin alchil inferior sau fenil m si n sînt fiecare independent, numere întregi de la 1 la 4, suma lui m si n fiind 3,4 sau 5; R4 este hidrogen, alchil inferior, fenil, tiazolil, pirimidinil, chinolinil, alchilcarbonil inferior, alchiloxicarbonil inferior, alchiloxicarbonil, alchilfenil inferior, alchildifenil inferior, fenilul fiind substituit facultativ cu cian sau alchil inferior, ciclohexil li ciclohexenilul, ambii fiind facultativ substituiti cu pâna la doi substituienti independent alesi din grupul constînd din cian si fenil, R5 este hidrogen, alchil inferior, fenil, hidroxi, alchloxi inferior, feniloxi, oxialchis inferior, fiind substituit cu morfolina, pirolidina sau piperidina, amino (aminoalchiloxicarbonil), fenilamino (fenilalchil inferior) amino, alchilfenil inferior-amino, fenilaqmino, alchenil inferior, oxifenilaminio, alchil inferior, aminoalchicarbonil inferior, fenilalchil inferior, alchifenil carbonil inferior, aminocarbonil, fenilcarbonil, fenilaminocarbonil, carbonil alchil inferior aril, alchiloxicarbonil in
RO118137A 1984-03-26 1985-03-26 Procedeu pentru prepararea unor derivati de piridazinamina RO91197B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59344484A 1984-03-26 1984-03-26
US06/702,772 US5001125A (en) 1984-03-26 1985-02-15 Anti-virally active pyridazinamines

Publications (2)

Publication Number Publication Date
RO91197A RO91197A (ro) 1987-06-30
RO91197B true RO91197B (ro) 1987-07-01

Family

ID=27081705

Family Applications (1)

Application Number Title Priority Date Filing Date
RO118137A RO91197B (ro) 1984-03-26 1985-03-26 Procedeu pentru prepararea unor derivati de piridazinamina

Country Status (22)

Country Link
US (3) US5001125A (ro)
EP (1) EP0156433B1 (ro)
KR (1) KR870001158B1 (ro)
AT (1) ATE61050T1 (ro)
AU (1) AU576563B2 (ro)
BG (1) BG43690A3 (ro)
CA (1) CA1238321A (ro)
CZ (1) CZ277730B6 (ro)
DE (1) DE3581819D1 (ro)
DK (1) DK166277C (ro)
ES (1) ES8606289A1 (ro)
FI (1) FI85373C (ro)
GR (1) GR850714B (ro)
HU (1) HU198010B (ro)
IL (1) IL74707A (ro)
NO (1) NO161257C (ro)
NZ (1) NZ211494A (ro)
PH (1) PH22495A (ro)
PT (1) PT80157B (ro)
RO (1) RO91197B (ro)
SU (1) SU1384198A3 (ro)
ZW (1) ZW5485A1 (ro)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
ES8802151A1 (es) * 1985-07-31 1988-04-01 Janssen Pharmaceutica Nv Un procedimiento para la preparacion de nuevos piridazinaminas.
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
US5231184A (en) * 1987-11-23 1993-07-27 Janssen Pharmaceutica N.V. Pridazinamine derivatives
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
JPH01139578A (ja) * 1987-11-26 1989-06-01 Morishita Seiyaku Kk ３−（１ｈ−イミダゾール−１−イル）ピリダジン誘導体
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
NZ233526A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Pyridazine derivatives and their pharmaceutical compositions
NZ233503A (en) * 1989-05-15 1991-06-25 Janssen Pharmaceutica Nv Substituted (thio)morpholinyl and piperazinyl alkylphenol ethers
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
US5100893A (en) * 1990-04-18 1992-03-31 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
FR2668151A1 (fr) * 1990-10-23 1992-04-24 Rhone Poulenc Agrochimie Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant.
JPH05117150A (ja) * 1991-10-25 1993-05-14 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
FR2703354B1 (fr) * 1993-03-31 1995-06-30 Lafon Labor Derives de 1, 2, 5, 6-tetrahydropyridine, leur procede de preparation et leurs applications en therapeutique.
KR100238346B1 (ko) * 1993-04-07 2000-03-02 오쓰까 아끼히꼬 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제
US5502063A (en) * 1993-10-11 1996-03-26 Sanofi 1-halopyridin-4-amino-4-alkylpiperidines
FR2721513B1 (fr) * 1994-06-23 1996-09-06 Lafon Labor Utilisation de dérivés de 1,2,5,6-tétrahydropyridine pour la fabrication de médicaments à effet sédatif.
FR2721514B1 (fr) * 1994-06-23 1996-09-06 Lafon Labor Compositions thérapeutiques comprenant des 3-phényl-3-hydroxypipéridines.
US5753679A (en) * 1995-05-10 1998-05-19 Hoffmann-La Roche Inc. Benzyl-piperidine derivatives
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
FR2745811B1 (fr) * 1996-03-07 1998-05-22 Sanofi Sa Glutarimide disubstitue procede pour sa preparation, et son utilisation
CN1131211C (zh) * 1997-10-27 2003-12-17 神经研究公司 在烟碱性乙酰胆碱受体上作为胆碱能配体的杂芳基二氮杂环烷类
US6251919B1 (en) * 1998-02-27 2001-06-26 Warner-Lambert Heterocyclic substituted aniline calcium channel blockers
CA2367695A1 (en) 1999-04-26 2000-11-02 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
US6833370B1 (en) 1999-05-21 2004-12-21 Abbott Laboratories Heterocycle substituted aminoazacycles useful as central nervous system agents
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
WO2001058959A1 (en) * 2000-02-07 2001-08-16 Janssen Pharmaceutica N.V. Use of thrombin receptor antagonists against gliosis
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
MXPA04007612A (es) * 2002-02-05 2004-11-10 Novo Nordisk As Aril- y heteroarilpiperazinas novedosas.
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
WO2003072548A1 (en) 2002-02-22 2003-09-04 Pharmacia & Upjohn Company Pyridyl sulfone derivatives as 5-ht receptor antagonists
HUP0200849A2 (hu) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
ES2375134T3 (es) 2003-07-30 2012-02-27 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos.
ATE555789T1 (de) * 2003-07-30 2012-05-15 Xenon Pharmaceuticals Inc Pyridazinderivate und deren verwendung als therapeutische mittel
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EA011211B1 (ru) 2003-11-20 2009-02-27 Янссен Фармацевтика Н. В. 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
US7855207B2 (en) 2003-11-20 2010-12-21 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adpribose) polymerase inhibitors
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
WO2005095380A1 (ja) * 2004-03-31 2005-10-13 Nippon Soda Co., Ltd. 環状アミン化合物および有害生物防除剤
BRPI0512938A (pt) 2004-06-30 2008-04-15 Janssen Pharmaceutica Nv derivados da quinazolinediona como inibidores parp
UA85593C2 (uk) 2004-06-30 2009-02-10 Янссен Фармацевтика Н.В. Похідні хіназолінону як інгібітори parp
MXPA06014542A (es) 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de poli(adp-ribosa) polimerasa-i.
AR051090A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005286790A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD)
CN101083992A (zh) 2004-09-20 2007-12-05 泽农医药公司 抑制人硬脂酰CoA去饱和酶的哒嗪衍生物
CN101083994A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途
EP1799668A1 (en) 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
AR051202A1 (es) * 2004-09-20 2006-12-27 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
CN101094846A (zh) * 2004-10-18 2007-12-26 伊莱利利公司 用作mglur3受体拮抗剂的1－(杂)芳基－3－氨基－吡咯烷衍生物
EP2029138A1 (en) * 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN1887875B (zh) * 2005-06-30 2011-04-06 深圳市东阳光实业发展有限公司 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途
BRPI0613564A2 (pt) 2005-07-04 2011-01-18 Novo Nordisk As compostos, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos
JP2009501733A (ja) * 2005-07-20 2009-01-22 メルク フロスト カナダ リミテツド ステアロイルコエンザイムａデルタ−９デサチュラーゼの阻害剤としてのヘテロ芳香族化合物
JP4871290B2 (ja) 2005-10-06 2012-02-08 日本曹達株式会社 架橋環状アミン化合物および有害生物防除剤
CA2647678A1 (en) * 2006-03-29 2007-11-08 Merck & Co., Inc. Diazepan orexin receptor antagonists
WO2007122411A1 (en) * 2006-04-26 2007-11-01 Astrazeneca Ab Diazepan-1-yl-sulfonyl derivatives for the treatment of metabolic syndrome
AU2007267197B2 (en) * 2006-05-29 2011-12-01 High Point Pharmaceuticals, Llc 3- (1, 3-Benzodioxol-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
WO2009053373A1 (en) 2007-10-26 2009-04-30 Janssen Pharmaceutica Nv Quinolinone derivatives as parp inhibitors
ES2367760T3 (es) 2008-03-27 2011-11-08 Janssen Pharmaceutica, N.V. Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
JP5492183B2 (ja) 2008-03-27 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびチューブリン重合阻害剤としてのテトラヒドロフェナントリジノンおよびテトラヒドロシクロペンタキノリノン
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US20160168124A1 (en) 2013-07-30 2016-06-16 Janssen Sciences Ireland Uc Substituted pyridine-piperazinyl analogues as rsv antiviral compounds
US10023565B2 (en) 2013-12-20 2018-07-17 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China N,N′ substituted piperidinamine compounds, and preparation method and usage thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL72956C (ro) * 1947-11-12
US3014034A (en) * 1959-01-22 1961-12-19 Ciba Pharm Prod Inc 1, 3-diaryl, 5-amino-pyridazinones
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
GB1184714A (en) * 1965-12-16 1970-03-18 Science Union & Cie Di- and Tri-Phenylpropyl Piperazine Derivatives
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
US4181723A (en) * 1973-08-02 1980-01-01 Sandoz Ltd. 3-Hydrazino-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazines
NL171985C (nl) * 1976-02-10 1983-06-16 Rhone Poulenc Ind Werkwijze voor het bereiden van preparaten met werking tegen schistosomiasis, de aldus verkregen gevormde preparaten en werkwijze voor het bereiden van 1,2-dithioolverbindingen.
US4104385A (en) * 1976-08-19 1978-08-01 Sterling Drug Inc. Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates
IN148482B (ro) * 1977-06-03 1981-03-07 Pfizer
HU176100B (en) * 1977-10-25 1980-12-28 Gyogyszerkutato Intezet Process for preparing new 3-/1-pyrazolyl/-pyridazine derivatives
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
DE2935359A1 (de) * 1979-09-01 1981-03-26 Basf Ag, 67063 Ludwigshafen 6-imidazolyl-3-hydrazino-pyridazine
US4304775A (en) * 1979-12-13 1981-12-08 Sterling Drug Inc. 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereof
FI70411C (fi) 1980-12-29 1986-09-19 Pfizer Foerfarande foer framstaellning av nya antihypertensiva 4-amino-6,7-dimetoxi-2-piperazinokinazolin derivat
FR2511366A1 (fr) * 1981-08-11 1983-02-18 Sanofi Sa Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
JPS5877866A (ja) * 1981-11-04 1983-05-11 Mitsui Toatsu Chem Inc アミノピリダジン誘導体および除草剤
GB2121140B (en) 1982-06-03 1985-12-04 Lucas Ind Plc Disc assemblies for brakes
FR2539741A1 (fr) * 1983-01-21 1984-07-27 Sanofi Sa Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
US4661493A (en) * 1985-03-29 1987-04-28 Pfizer Inc. Tioconazole and related compounds for control of Herpes simplex virus
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines

Also Published As

Publication number Publication date
DK134185A (da) 1985-09-27
ZW5485A1 (en) 1986-10-22
US5157035A (en) 1992-10-20
PT80157B (en) 1987-03-20
DK166277C (da) 1993-08-30
IL74707A (en) 1988-05-31
SU1384198A3 (ru) 1988-03-23
ES541521A0 (es) 1986-04-16
EP0156433A2 (en) 1985-10-02
HUT37614A (en) 1986-01-23
AU576563B2 (en) 1988-09-01
NO161257B (no) 1989-04-17
GR850714B (ro) 1985-06-14
CZ277730B6 (en) 1993-04-14
AU4034885A (en) 1985-10-03
CS195285A3 (en) 1992-11-18
KR870001158B1 (ko) 1987-06-13
RO91197A (ro) 1987-06-30
FI851177A0 (fi) 1985-03-25
PH22495A (en) 1988-09-12
FI851177L (fi) 1985-09-27
KR850006401A (ko) 1985-10-05
EP0156433B1 (en) 1991-02-27
NO161257C (no) 1989-07-26
US5001125A (en) 1991-03-19
BG43690A3 (en) 1988-07-15
DE3581819D1 (de) 1991-04-04
NZ211494A (en) 1988-05-30
IL74707A0 (en) 1985-06-30
FI85373C (fi) 1992-04-10
FI85373B (fi) 1991-12-31
DK166277B (da) 1993-03-29
HU198010B (en) 1989-07-28
ATE61050T1 (de) 1991-03-15
US5292738A (en) 1994-03-08
PT80157A (en) 1985-04-01
CA1238321A (en) 1988-06-21
NO851167L (no) 1985-09-27
DK134185D0 (da) 1985-03-25
ES8606289A1 (es) 1986-04-16
EP0156433A3 (en) 1986-07-23

Similar Documents

Publication Publication Date Title
RO91197B (ro) Procedeu pentru prepararea unor derivati de piridazinamina
ES8603870A1 (es) Un procedimiento para la preparacion de derivados de 2,2'-iminobisetanol.
GB2143734B (en) Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
HUT51254A (en) Process for producing amino acid derivatives and pharmaceutical compositions comprising same as active ingredient
ES8800682A1 (es) Un procedimiento para la preparacion de nuevas (4-piperidinilmetil y heteropurinas)
PT83647A (en) Process for the preparation of novel pharmaceutical benzimidazole derivatives and of pharmaceutical compositions containing the same
HUT37781A (en) Process for producing 1-fluorphenyl-butyl-4-/2-pirimidinyl/-piperazine derivatives and pharmaceutical compositions containing them as active agents
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
AU5231186A (en) Amino-salicylic acid derivatives salts thereof process for their preparation and pharmaceutical compositions containing them
HUT38097A (en) Process for preparing substituted benzopyrans and pharmaceutical compositions containing them as active substances
HUT50112A (en) Process for producing phenoxyalkyl-carboxylic acid derivatives and pharmaceutical compositions containing them as active component
HUT43848A (en) Process for producing pyridinyl-piperazine derivatives and pharmaceutical compositions containing them as active agents
HU895241D0 (en) Process for the preparation of substituted 1,3,5-triazin-trione derivatives and pharmaceutical compositions containing said compounds as active ingredient
IE56229B1 (en) 2-piperazinyl-or-homopiperazinyl-quinazoline derivatives their production and pharmaceutical compositions containing them
HU895952D0 (en) Process for the preparation of substituted pyrrolidone-2-carboxylic acid derivatives and pharmaceutical compositions containing them
HUT47077A (en) Process for producing hydrocinnamomic acid derivatives and pharmaceutical compositions containing them as active components
HUT41757A (en) Process for producing pharmaceutical compositions containing e-desmethyl-mevalonic acid derivatives and process for producing the active agents
HUT43052A (en) Process for preparing quinoline-carboxylic acid derivatives and pharmaceutical compositions containing thereof as active ingredients
HUT53121A (en) Process for producing amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DE3372772D1 (en) Quinazolinone derivatives, process for their preparation and their use in medicaments
HUT49590A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same as active ingredient
HU896342D0 (en) Process for the preparation of benzohydroxane acid derivatives and herbicides compositions containing them as active ingredients
HUT40428A (en) Process for producing sulfamoyl-benzoic acid derivatives and pharmaceutical compositions containing them as active agents