ES8200883A1 - Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos - Google Patents
Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activosInfo
- Publication number
- ES8200883A1 ES8200883A1 ES495105A ES495105A ES8200883A1 ES 8200883 A1 ES8200883 A1 ES 8200883A1 ES 495105 A ES495105 A ES 495105A ES 495105 A ES495105 A ES 495105A ES 8200883 A1 ES8200883 A1 ES 8200883A1
- Authority
- ES
- Spain
- Prior art keywords
- antiagressive
- preparation
- piperazine derivatives
- compounds
- medicines containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Cookers (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FENILPUPERAZINA DE FORMULA (I) Y DE SUS SALES CON ACIDOS FISIOLOGICAMENTE COMPATIBLES, QUE SON FARMACEUTICAMENTE ACTIVOS Y ANTIAGRESIVOS; FORMULA EN LA QUE R1 ES UNO DE VARIOS TIPOS DE RADICALES; R2 ES HIDROGENO O UN RADICAL ALCOHILO C1-3 ES TRIFLUORO-METILO / HALOGENO; T ES OXIGENO O AZUFRE, Y M VALE 0 O 1. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R1, R2 Y R3 TIENEN LOS MISMO SIGNIFICADOS QUE EN LA FORMULA (I) Y X ES CLORO, BROMO O TOSILATO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE O SIN EL, EN PRESENCIA DE UNA BASE QUE FIJA EL ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE EL AMBIENTE Y 60 C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7901633 | 1979-03-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200883A1 true ES8200883A1 (es) | 1981-11-16 |
| ES495105A0 ES495105A0 (es) | 1981-11-16 |
Family
ID=19832723
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488988A Expired ES8106898A1 (es) | 1979-03-01 | 1980-02-27 | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos |
| ES495106A Granted ES495106A0 (es) | 1979-03-01 | 1980-09-16 | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos |
| ES495105A Granted ES495105A0 (es) | 1979-03-01 | 1980-09-16 | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488988A Expired ES8106898A1 (es) | 1979-03-01 | 1980-02-27 | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos |
| ES495106A Granted ES495106A0 (es) | 1979-03-01 | 1980-09-16 | Un metodo de preparar derivados de fenil-piperazina farma- ceuticamente activos |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0015615B1 (es) |
| JP (1) | JPS55141478A (es) |
| AT (1) | ATE2219T1 (es) |
| AU (1) | AU532411B2 (es) |
| CA (1) | CA1138461A (es) |
| CS (1) | CS216525B2 (es) |
| DD (1) | DD151408A5 (es) |
| DE (1) | DE3061561D1 (es) |
| DK (1) | DK84380A (es) |
| ES (3) | ES8106898A1 (es) |
| FI (1) | FI800588A (es) |
| GR (1) | GR67005B (es) |
| HU (1) | HU182070B (es) |
| IE (1) | IE49526B1 (es) |
| IL (1) | IL59489A (es) |
| PH (1) | PH17025A (es) |
| PL (1) | PL126161B1 (es) |
| SU (1) | SU1039442A3 (es) |
| YU (1) | YU54680A (es) |
| ZA (1) | ZA801119B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| NL8005131A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met analgetische werking. |
| US4457931A (en) * | 1982-09-27 | 1984-07-03 | Selvi & C. S.P.A. | Piperazine derivatives with anticholinergic and/or antihistaminic activity |
| JPH0660160B2 (ja) * | 1985-12-13 | 1994-08-10 | テルモ株式会社 | アミド誘導体およびこれを含有する抗アレルギ−剤 |
| US5340812A (en) * | 1989-04-22 | 1994-08-23 | John Wyeth & Brother, Limited | Piperazine derivatives |
| DK0395313T3 (da) * | 1989-04-22 | 2000-06-19 | American Home Prod | Tertiære alkyl-funktionaliserede piperazin-derivater |
| US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
| FI102175B1 (fi) * | 1989-04-22 | 1998-10-30 | Wyeth John & Brother Ltd | Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi |
| DK203990D0 (da) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
| GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2833770A (en) * | 1958-05-06 | Chj-chj | ||
| US2722529A (en) * | 1955-11-01 | Amides of certain l-amevoalkyl-x-phenyl | ||
| BE788280A (fr) * | 1971-09-04 | 1973-02-28 | Pfizer | Nouvelles 1-(3-trifluoro-methyl-phenyl)-4-((amido cyclique)- alkyl) piperazines et composition pharmaceutique les contenant |
| GB1443598A (en) * | 1973-07-06 | 1976-07-21 | Acraf | 1- 3-acetylaminopropyl-4-2,5-dichlorophenyl-piperazine |
| FR2306694A1 (fr) * | 1975-04-07 | 1976-11-05 | Parcor | Derives de la piperazine |
-
1980
- 1980-02-25 AU AU55848/80A patent/AU532411B2/en not_active Ceased
- 1980-02-27 FI FI800588A patent/FI800588A/fi not_active Application Discontinuation
- 1980-02-27 SU SU802890551A patent/SU1039442A3/ru active
- 1980-02-27 GR GR61296A patent/GR67005B/el unknown
- 1980-02-27 ZA ZA00801119A patent/ZA801119B/xx unknown
- 1980-02-27 ES ES488988A patent/ES8106898A1/es not_active Expired
- 1980-02-27 PL PL1980222294A patent/PL126161B1/pl unknown
- 1980-02-27 DK DK84380A patent/DK84380A/da not_active Application Discontinuation
- 1980-02-28 YU YU00546/80A patent/YU54680A/xx unknown
- 1980-02-28 CS CS801368A patent/CS216525B2/cs unknown
- 1980-02-28 PH PH23695A patent/PH17025A/en unknown
- 1980-02-28 IL IL59489A patent/IL59489A/xx unknown
- 1980-02-28 EP EP80200173A patent/EP0015615B1/en not_active Expired
- 1980-02-28 IE IE405/80A patent/IE49526B1/en unknown
- 1980-02-28 AT AT80200173T patent/ATE2219T1/de not_active IP Right Cessation
- 1980-02-28 DE DE8080200173T patent/DE3061561D1/de not_active Expired
- 1980-02-29 HU HU80474A patent/HU182070B/hu unknown
- 1980-02-29 CA CA000346735A patent/CA1138461A/en not_active Expired
- 1980-03-01 JP JP2466480A patent/JPS55141478A/ja active Pending
- 1980-03-03 DD DD80219413A patent/DD151408A5/de unknown
- 1980-09-16 ES ES495106A patent/ES495106A0/es active Granted
- 1980-09-16 ES ES495105A patent/ES495105A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE49526B1 (en) | 1985-10-16 |
| AU532411B2 (en) | 1983-09-29 |
| JPS55141478A (en) | 1980-11-05 |
| ES488988A0 (es) | 1981-09-01 |
| ATE2219T1 (de) | 1983-01-15 |
| EP0015615B1 (en) | 1983-01-12 |
| SU1039442A3 (ru) | 1983-08-30 |
| CS216525B2 (en) | 1982-11-26 |
| AU5584880A (en) | 1980-09-04 |
| CA1138461A (en) | 1982-12-28 |
| IL59489A0 (en) | 1980-05-30 |
| PH17025A (en) | 1984-05-17 |
| EP0015615A1 (en) | 1980-09-17 |
| GR67005B (es) | 1981-05-18 |
| FI800588A (fi) | 1980-09-02 |
| ES8106898A1 (es) | 1981-09-01 |
| ES8200884A1 (es) | 1981-11-16 |
| PL222294A1 (es) | 1980-12-01 |
| DD151408A5 (de) | 1981-10-21 |
| IE800405L (en) | 1980-09-01 |
| YU54680A (en) | 1983-09-30 |
| ES495105A0 (es) | 1981-11-16 |
| DK84380A (da) | 1980-09-02 |
| DE3061561D1 (en) | 1983-02-17 |
| PL126161B1 (en) | 1983-07-30 |
| HU182070B (en) | 1983-12-28 |
| ZA801119B (en) | 1981-09-30 |
| ES495106A0 (es) | 1981-11-16 |
| IL59489A (en) | 1984-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000601 |