ES8200347A1 - Procedimiento de preparacion de derivados de la piridina. - Google Patents

Procedimiento de preparacion de derivados de la piridina.

Info

Publication number
ES8200347A1
ES8200347A1 ES495745A ES495745A ES8200347A1 ES 8200347 A1 ES8200347 A1 ES 8200347A1 ES 495745 A ES495745 A ES 495745A ES 495745 A ES495745 A ES 495745A ES 8200347 A1 ES8200347 A1 ES 8200347A1
Authority
ES
Spain
Prior art keywords
preparation
pyridine derivatives
medicaments containing
derivatives
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495745A
Other languages
English (en)
Other versions
ES495745A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clin Midy
Original Assignee
Clin Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clin Midy filed Critical Clin Midy
Publication of ES495745A0 publication Critical patent/ES495745A0/es
Publication of ES8200347A1 publication Critical patent/ES8200347A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDINA, DE FORMULA (I), Y DE SUS SALES DE ACIDOS INORGANICOS Y ORGANICOS FISIOLOGICAMENTE COMPATIBLES, QUE TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTIARRITMICA Y ANTIAGREGANTE PLAQUETARIA; FORMULA EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 2-4. CONSISTE EN LA REACCION DE UNOS DE LOS PIRIDILACETONITRILOS CON UNA CETONA O UN ALDEHIDO DE FORMULA R4-COR5, EN LA QUE R4 ES HIDROGENO O ALQUILO Y R5 ES ALQUILO, EN PRESENCIA DE ACIDO ACETICO Y PIRIDINA; SEGUIDA DE LA REDUCCION CATALITICA DEL NITRILO ETILENICO OBTENIDO. EL NITRILO SATURADO SE SOMETE A UNA REACCION DE ALQUILACION CON UN COMPUESTO DE FORMULA (II), EN LA QUE X ES UN HALOGENO, Y POSTERIORMENTE A UNA HIDROLISIS POR METODOS CONVENCIONALES PARA OBTENER LA AMIDA CORRESPONDIENTE.
ES495745A 1979-10-11 1980-10-08 Procedimiento de preparacion de derivados de la piridina. Expired ES8200347A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7925370A FR2467200A1 (fr) 1979-10-11 1979-10-11 Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

Publications (2)

Publication Number Publication Date
ES495745A0 ES495745A0 (es) 1981-11-16
ES8200347A1 true ES8200347A1 (es) 1981-11-16

Family

ID=9230594

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495745A Expired ES8200347A1 (es) 1979-10-11 1980-10-08 Procedimiento de preparacion de derivados de la piridina.

Country Status (26)

Country Link
US (1) US4356177A (es)
EP (1) EP0027412B1 (es)
JP (1) JPS5661355A (es)
AR (2) AR231129A1 (es)
AT (1) ATE5561T1 (es)
AU (1) AU540556B2 (es)
BR (1) BR8006547A (es)
CA (1) CA1156653A (es)
CS (2) CS225840B2 (es)
DD (1) DD153549A5 (es)
DE (1) DE3065906D1 (es)
DK (1) DK156650C (es)
ES (1) ES8200347A1 (es)
FI (1) FI75339C (es)
FR (1) FR2467200A1 (es)
GR (1) GR69616B (es)
HU (1) HU184330B (es)
IE (1) IE50827B1 (es)
IL (1) IL61250A (es)
NO (1) NO153849C (es)
NZ (1) NZ195233A (es)
PH (1) PH18748A (es)
PT (1) PT71888B (es)
SU (2) SU1011048A3 (es)
YU (2) YU42537B (es)
ZA (1) ZA806180B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535722B1 (fr) * 1982-11-08 1985-06-28 Sanofi Sa Derives de la g-butyrolactone protecteurs du myocarde presentant une activite antiarythmique, procede pour leur preparation et medicaments en contenant
FR2535721A1 (fr) * 1982-11-08 1984-05-11 Sanofi Sa Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives
US4783537A (en) * 1985-11-13 1988-11-08 Pennwalt Corporation α-(aminoalkyl)-arylacetic acid derivatives
US4847301A (en) * 1985-11-13 1989-07-11 Pennwalt Corporation Methods of use of α-(aminoalkyl)-arylacetic acid derivatives
FR2856061A1 (fr) * 2003-06-11 2004-12-17 Chrysalon Derives polycycliques ortho-condenses de l'aminopyrrole a substituant electroattracteur chimiotheques combinatoires desdits derives et leur procede d'obtention

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL70757C (es) * 1947-10-13
GB915804A (en) * 1958-04-12 1963-01-16 Degussa Process for the production of basically substituted carboxylic acid amides
FR2485M (fr) * 1961-05-17 1964-04-27 Searle & Co Nouveaux régulateurs cardiaques.
CA1073892A (en) * 1976-08-03 1980-03-18 John M. Holmes Mixed metal amide catalysts for h-d exchange in amines

Also Published As

Publication number Publication date
CS225823B2 (en) 1984-02-13
CA1156653A (en) 1983-11-08
US4356177A (en) 1982-10-26
FR2467200A1 (fr) 1981-04-17
ES495745A0 (es) 1981-11-16
YU261180A (en) 1983-09-30
IE802112L (en) 1981-04-11
DK156650C (da) 1990-02-12
ATE5561T1 (de) 1983-12-15
DD153549A5 (de) 1982-01-13
CS225840B2 (en) 1984-02-13
IE50827B1 (en) 1986-07-23
DK428280A (da) 1981-04-12
BR8006547A (pt) 1981-04-14
DE3065906D1 (en) 1984-01-19
IL61250A (en) 1983-11-30
AR231975A1 (es) 1985-04-30
YU21283A (en) 1983-09-30
PH18748A (en) 1985-09-19
NO153849B (no) 1986-02-24
NO153849C (no) 1986-06-04
PT71888B (fr) 1981-08-14
EP0027412B1 (fr) 1983-12-14
SU1127529A3 (ru) 1984-11-30
NO803051L (no) 1981-04-13
EP0027412A1 (fr) 1981-04-22
YU42537B (en) 1988-10-31
AU540556B2 (en) 1984-11-22
JPS5661355A (en) 1981-05-26
JPH0115501B2 (es) 1989-03-17
PT71888A (fr) 1980-11-01
SU1011048A3 (ru) 1983-04-07
ZA806180B (en) 1981-11-25
AU6328380A (en) 1981-04-30
AR231129A1 (es) 1984-09-28
FI75339B (fi) 1988-02-29
FI803221L (fi) 1981-04-12
FR2467200B1 (es) 1982-07-02
FI75339C (fi) 1988-06-09
HU184330B (en) 1984-08-28
NZ195233A (en) 1983-05-10
GR69616B (es) 1982-07-05
DK156650B (da) 1989-09-18
IL61250A0 (en) 1980-12-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303